Drugs of abuse and benzodiazepines in the Madrid Region (Central Spain): Seasonal variation in river waters, occurrence in tap water and potential environmental and human risk

Environment International

Volumn 70, Issue , 2014, Pages 76-87

  Mendoza, A ^a   Rodriguez Gil J L ^a,b   Gonzalez Alonso S ^a   Mastroianni, N ^c   Lopez de Alda M ^c   Barcelo D ^c,d   Valcarcel Y ^a  

^a UNIVERSIDAD REY JUAN CARLOS   (Spain)

^b UNIVERSITY OF GUELPH   (Canada)

^c INSTITUTE OF ENVIRONMENTAL ASSESSMENT AND WATER RESEARCH   (Spain)

^d UNIVERSITY OF GIRONA   (Spain)

Author keywords

Drugs of abuse; Environmental risk; Human risk assessment; Madrid Region; Surface water; Tap water

Indexed keywords

BIOMOLECULES; DRUG PRODUCTS; ETHYLENE; RISK ASSESSMENT; SURFACE WATERS;

DRUGS OF ABUSE; ENVIRONMENTAL RISKS; HUMAN RISK ASSESSMENT; MADRID REGION; TAP WATER;

METABOLITES;

2 ETHYLENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; 2 OXO 3 HYDROXY LYSERGIC ACID DIETHYLAMIDE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALPRAZOLAM; AMPHETAMINE; BENZODIAZEPINE DERIVATIVE; BENZOYLECGONINE; COCAINE; DIAMORPHINE; DIAZEPAM; DRINKING WATER; DRONABINOL; DRUG METABOLITE; EPHEDRINE; HOMOCOCAINE; ILLICIT DRUG; LORAZEPAM; LYSERGIDE; METHADONE; METHAMPHETAMINE; MORPHINE 6 ACETATE; RIVER WATER; TAP WATER; TETRAHYDROCANNABINOLIC ACID; UNCLASSIFIED DRUG;

CONCENTRATION (COMPOSITION); DOSE-RESPONSE RELATIONSHIP; DRUG; HAZARD ASSESSMENT; HEALTH RISK; METABOLITE; PUBLIC HEALTH; RISK ASSESSMENT; SURFACE WATER;

ARTICLE; ENVIRONMENTAL HAZARD; ENVIRONMENTAL PARAMETERS; GEOGRAPHIC DISTRIBUTION; HAZARD QUOTIENT METHOD; HEALTH HAZARD; HUMAN; MEASURED ENVIRONMENTAL CONCENTRATION; POLLUTION MONITORING; PREVALENCE; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RISK; RISK ASSESSMENT; SEASONAL VARIATION; SPAIN; SUMMER; WATER ANALYSIS; WATER POLLUTION; WATER SUPPLY; WINTER;

JARAMA RIVER; MADRID [SPAIN]; MANZANARES RIVER; SPAIN;

DRUGS OF ABUSE; ENVIRONMENTAL RISK; HUMAN RISK ASSESSMENT; MADRID REGION; SURFACE WATER; TAP WATER;

ADULT; BENZODIAZEPINES; DRINKING WATER; DRONABINOL; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FEMALE; HUMANS; LYSERGIC ACID DIETHYLAMIDE; MALE; MORPHINE DERIVATIVES; RIVERS; SEASONS; SPAIN; STREET DRUGS; WATER POLLUTION, CHEMICAL;

EID: 84901983016     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2014.05.009     Document Type: Article

References (75)

1. Baker D.R., Kasprzyk-Hordern B. Spatial and temporal occurrence of pharmaceuticals and illicit drugs in the aqueous environment and during wastewater treatment: new developments. Sci Total Environ 2013, 454-455:442-456.
2. Baselt R.C. Disposition of toxic drugs and chemicals in man 2004, Biomedical Publication, Foster City, CA. 7th ed.
3. Berset J.D., Brenneisen R., Mathieu C. Analysis of licit and illicit drugs in waste, surface and lake water samples using large volume direct injection high performance liquid chromatography-electrospray tandem mass spectrometry (HPLC-MS/MS). Chemosphere 2010, 81:859-866.
4. Bijlsma L., Sancho J.V., Pitarch E., Ibáñez M., Hernández F. Simultaneous ultra-high pressure liquid chromatography-tandem mass spectrometry determination of amphetamine and amphetamine-like stimulants, cocaine and its metabolites, and a cannabis metabolite in surface water and urban wastewater. J Chromatogr A 2009, 1216:3078-3089.
5. Boleda M.R., Galceran M.T., Ventura F. Monitoring of opiates, cannabinoids and their metabolites in wastewater, surface water and finished water in Catalonia, Spain. Water Res 2009, 43(4):1126-1136.
6. Boleda M.R., Majamaa K., Aerts P., Gómez V., Galceran M.T., Ventura F. Removal of drugs of abuse from municipal waste water using reverse osmosis membranes. Desalin Water Treat 2010, 21:1-9.
7. Boleda M.R., Galceran M.T., Ventura F. Behaviour of pharmaceuticals and drugs of abuse in a drinking water treatment plant (DWTP) using combined conventional and ultrafiltration and reverse osmosis (UF/RO) treatment. Environ Pollut 2011, 159:1584-1591.
8. Boleda M.R., Huerta-Fontela M., Ventura F., Galceran M.T. Evaluation of the presence of drugs of abuse in tap waters. Chemosphere 2011, 84:1601-1607.
9. Boles T.M., Wells M.J.M. Analysis of amphetamine and methamphetamine as emerging pollutants in wastewater and wastewater-impacted streams. J Chromatogr A 2010, 1217:2561-2568.
10. Bones J., Thomas K.V., Paul B. Using environmental analytical data to estimate levels of community consumption of illicit drugs and abused pharmaceuticals. J Environ Monit 2007, 9(7):701-707.
11. Cooper E.R., Siewicki T.C., Phillips K. Preliminary risk assessment database and risk ranking of pharmaceuticals in the environment. Sci Total Environ 2008, 398:26-33.
12. Daughton C.G., Ruhoy I.S. The afterlife of drugs and the role of PharmEcovigilance. Drug Saf 2008, 31(12):1069-1082.
13. EDADES Encuesta Domiciliaria sobre Alcohol y Drogas en España (EDADES) Informe 2011/2012 2012, Delegación del Gobierno para el Plan Nacional sobre Drogas, [Available at http://www.mspsi.es. Accessed in April 2013].
14. EFSA Guidance on selected default values to be used by the European Food Safety Authority (EFSA) Scientific Committee, Scientific Panels and Units in the absence of actual measured data. EFSA J 2012, 3.
15. Esteban S., Valcárcel Y., Catalá M., González Castromil M. Psychoactive pharmaceutical residues in the watersheds of Galicia. Gac Sanit 2012, 26(5):457-459.
16. EU Technical Guidance Document in support of Council Directive 93/67/EEC on Risk Assessment for New Notified Substances and Commission Regulation (EC) 1488/94 on risk assessment for existing substances (part II: environmental risk assessment) 2003, Office for Official Publications of the European Communities, Luxembourg.
17. EU Technical Guidance Document in support of Council Directive 93/67/EEC on Risk Assessment for New Notified Substances and Commission Regulation (EC) 1488/94 on risk assessment for existing substances (part I: general introduction & risk assessment for human health) 2003, Office for Official Publications of the European Communities, Luxembourg.
18. EU Common implementation strategy for the water framework directive (2000/60/EC) guidance document no. 27. Technical guidance for deriving environmental quality standards (technical report - 2011-055) 2011, European Communities.
19. Focazio M.J., Kolpin D.W., Barnes K.K., Furlong E.T., Meyer M.T., Zaugg S.D., et al. A national reconnaissance for pharmaceuticals and other organic wastewater contaminants in the United States-(II) untreated drinking water sources. Sci Total Environ 2008, 402:201-216.
20. Gerrity D., Trenholm R.A., Snyder S.A. Temporal variability of pharmaceuticals and illicit drugs in wastewater and the effects of a major sporting event. Water Res 2011, 45:5399-5411.
21. Gheorghe A., van Nuijs A., Pecceu B., Bervoets L., Jorens P.G., Blust R., et al. Analysis of cocaine and its principal metabolites in waste and surface water using solid-phase extraction and liquid chromatography-ion trap tandem mass spectrometry. Anal Bioanal Chem 2008, 391(4):1309-1319.
22. Gros M., Petrovic M., Ginebreda A., Barceló D. Removal of pharmaceuticals during wastewater treatment and environmental risk assessment using hazard indexes. Environ Int 2010, 36(1):15-26.
23. Huerta-Fontela M., Galceran M.T., Martin-Alonso J., Ventura F. Occurrence of psychoactive stimulatory drugs in wastewaters in north-eastern Spain. Sci Total Environ 2008, 397:31-40.
24. Huerta-Fontela M., Galceran M.T., Ventura F. Stimulatory drugs of abuse in surface waters and their removal in a conventional drinking water treatment plant. Environ Sci Technol 2008, 42(18):6809-6816.
25. Huerta-Fontela M., Galceran M.T., Ventura F. Occurrence and removal of pharmaceuticals and hormones through drinking water treatment. Water Res 2011, 45:1432-1442.
26. Hughes S.R., Kay P., Brown L.E. Global synthesis and critical evaluation of pharmaceutical data sets collected from river systems. Environ Sci Technol 2013, 47:661-677.
27. Hummel D., Löffler D., Fink G., Ternes T.A. Simultaneous determination of psychoactive drugs and their metabolites in aqueous matrices by liquid chromatography mass spectrometry. Environ Sci Technol 2006, 40:7321-7328.
28. INE Encuesta sobre el Suministro y Saneamiento del Agua. Año 2011 2013, Instituto Nacional de Estadística, [Available at http://www.ine.es/prensa/np807.pdf. Accessed in April 2014].
29. National Statistics Institute on-line database 2012, [Accessed in April 2013].
30. Jones D.S., Barnthouse L.W., Suter G.W., Efroymson R.A., Field J.M., Beauchamp J.J. Ecological risk assessment in a large river-reservoir: 3. Benthic invertebrates. Environ Toxicol Chem 1999, 18:599-609.
31. Jones O.A., Lester J.N., Voulvoulis N. Pharmaceuticals: a threat to drinking water?. Trends Biotechnol 2005, 23(4):163-167.
32. Jones-Lepp T.L., Sanchez C., Alvarez D.A., Wilson D.C., Taniguchi-Fu R.L. Point sources of emerging contaminants along the Colorado River Basin: source water for the arid Southwestern United States. Sci Total Environ 2012, 430:237-245.
33. Lanz M., Thormann W. Characterization of the stereoselective metabolism of methadone and its primary metabolite via cyclodextrin capillary electrophoretic determination of their urinary enantiomers. Electrophoresis 1996, 17:1945-1949.
34. Lilius H., Isomaa B., Holmström T. A comparison of the toxicity of 50 reference chemicals to freshly isolated rainbow trout hepatocytes and Daphnia magna. Aquat Toxicol 1994, 30:47-60.
35. Loganathan B., Phillips M., Mowery H., Jones-Lepp T.L. Contamination profiles and mass loadings of macrolide antibiotics and illicit drugs from a small urban wastewater treatment plant. Chemosphere 2009, 75:70-77.
36. Mari F., Politi L., Biggeri A., Accetta G., Trignano C., Di Padua M., et al. Cocaine and heroin in waste water plants: a 1-year study in the city of Florence, Italy. Forensic Sci Int 2009, 189:88-92.
37. Metcalfe C., Tindale K., Li H., Rodayan A., Yargeau V. Illicit drugs in Canadian municipal wastewater and estimates of community drug use. Environ Pollut 2010, 158(10):3179-3185.
38. Mompelat S., Le Bot B., Thomas O. Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water. Environ Int 2009, 35:803-814.
39. MSSSI Calidad del agua de consumo humano en España. Informe Técnico. Año 2011 2011, Ministerio de Sanidad, Servicios Sociales e Igualdad, [Available at http://www.msssi.gob.es/profesionales/saludPublica/docs/agua_consumo_v3.pdf. Accessed in April 2014].
40. Musolff A., Leschik S., Möder M., Strauch G., Reinstorf F., Schirmer M. Temporal and spatial patterns of micropollutants in urban receiving waters. Environ Pollut 2009, 157:3069-3077.
41. OECD Manual for investigation of hpv chemicals. Chapter 4: initial assessment of data 2002, Organisation for Economic Co-operation and Development, Paris, France.
42. OECD Ecological categorization results from the Canadian domestic substance list 2013, Organisation for Economic Co-operation and Development, Paris, France.
43. Oller I., Malato S., Sánchez-Pérez J.A. Combination of advanced oxidation processes and biological treatments for wastewater decontamination. A review. Sci Total Environ 2011, 409:4141-4166.
44. Ort C., Lawrence M.G., Rieckermann J., Joss A. Sampling for pharmaceuticals and personal care products (PPCPs) and illicit drugs in wastewater systems: are your conclusions valid? A critical review. Environ Sci Technol 2010, 44:6024-6035.
45. Pal R., Megharaj M., Paul Kirkbride K., Naidu R. Illicit drugs and the environment-a review. Sci Total Environ 2012, 10.1016/j.scitotenv.2012.05.086.
46. Parolini M., Binelli A. Adverse effects induced by ecgonine methyl ester to the zebra mussel: a comparison with the benzoylecgonine. Environ Pollut 2013, 182:371-378.
47. Parolini M., Pedriali A., Riva C., Binelli A. Sub-lethal effects caused by the cocaine metabolite benzoylecgonine to the freshwater mussel Dreissena polymorpha. Sci Total Environ 2013, 444:43-50.
48. Pedriali A., Riva C., Parolini M., Cristoni S., Sheehan D., Binelli A. A redox proteomic investigation of oxidative stress caused by benzoylecgonine in the freshwater bivalve Dreissena polymorpha. Drug Test Anal 2013, 5:646-656.
49. Postigo C., López de Alda M.J., Barceló D. Fully automated determination in the low nanogram per liter level of different classes of drugs of abuse in sewage water by on-line solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry. Anal Chem 2008, 80(9):3123-3134.
50. 2: a non-intrusive tool for drug abuse estimation at the community level. Trends Anal Chem 2008, 27(11):1053-1069.
51. Postigo C., López de Alda M.J., Barceló D. Drugs of abuse and their metabolites in the Ebro River basin: occurrence in sewage and surface water, sewage treatment plants removal efficiency, and collective drug usage estimation. Environ Int 2010, 36(1):75-84.
52. Postigo C., López de Alda M., Barceló D. Occurrence of illicit drugs in wastewater in Spain. Illicit drugs in the environment: occurrence, analysis and fate using mass spectrometry 2011, 117-136. John Wiley & Sons, Inc., Hobokenm New Jersey. S. Castiglioni, E. Zuccato, R. Fanelli (Eds.).
53. Postigo C., López de Alda M., Barceló D. Evaluation of drugs of abuse use and trends in a prison through wastewater analysis. Environ Int 2011, 37(1):49-55.
54. Richardson S. Environmental mass spectrometry: emerging contaminants and current issues. Anal Chem 2008, 80:4373-4402.
55. Sanderson H., Johnson D.J., Reitsma T., Brain R.A., Wilson C.J., Solomon K.R. Ranking and prioritization of environmental risks of pharmaceuticals in surface waters. Regul Toxicol Pharmacol 2004, 39:158-183.
56. Schwab B.W., Hayes E.P., Fiori J.M., Mastrocco F.J., Roden N.M., Cragin D., et al. Human pharmaceuticals in US surface waters: a human health risk assessment. Regul Toxicol Pharmacol 2005, 42:296-312.
57. Senta I., Krizman I., Ahel M., Terzic S. Integrated procedure for multiresidue analysis of dissolved and particulate drugs in municipal wastewater by liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem 2013, 405(10):3255-3268.
58. SRC/Physprop The Physical Properties Database (PHYSPROP) Available at, [Accessed in April 2013]. http://www.srcinc.com.
59. Terzic S., Senta I., Ahel M. Illicit drugs in wastewater of the city of Zagreb (Croatia)-estimation of drug abuse in a transition country. Environ Pollut 2010, 158:2686-2693.
60. Thomas R.J. The toxicologic and teratologic effects of δ9-tetrahydrocannabinol in the Zebrafish embryo. Toxicol Appl Pharmacol 1975, 32:184-190.
61. Thomas K.V., Bijlsma L., Castiglioni S., Covaci A., Emke E., Grabic R., et al. Comparing illicit drug use in 19 European cities through sewage analysis. Sci Total Environ 2012, 432:432-439.
62. UNODC (United Nations Office on Drugs and Crime) World drug report 2013 Available at, [Accessed in August 2013]. http://www.unodc.org/unodc/secured/wdr/wdr2013/World_Drug_Report_2013.pdf.
63. US EPA Terms of environment: glossary, abbreviations and acronyms (EPA publication no. 175-B-97-001) 1997, U.S. Environmental Protection Agency, Washington D.C.
64. US EPA Ecological risk assessment guidance for superfund: process for designing and conducting ecological risk assessments - interim final (EPA publication no. 540/R-97/006) 1997, U.S. Environmental Protection Agency, Washington D.C.
65. US EPA Guidelines for ecological risk assessment (EPA publication no. 630/R-95/002F) 1998, U.S. Environmental Protection Agency, Washington D.C.
66. US EPA Estimation Programs Interface Suite(tm) for Microsoft(r) Windows v 4.11 2013, U. S. Environmental Protection Agency, Washington D.C.
67. Valcárcel Y., Martínez F., González-Alonso S., Segura Y., Catalá M., Molina R., et al. Drugs of abuse in surface and tap waters of the Tagus River basin: heterogeneous photo-Fenton process is effective in their degradation. Environ Int 2012, 41:36-43.
68. Valcárcel Y., González Alonso S., Rodríguez-Gil J.L., Castaño A., Montero J.C., Criado-Álvarez J.J., et al. Seasonal variation of pharmaceutically active compounds in surface (Tagus River) and tap water (Central Spain). Environ Sci Pollut Res 2013, 20(3):1396-1412.
69. van Nuijs A.L.N., Pecceu B., Theunis L., Dubois N., Charlier C., Jorens P., et al. Spatial and temporal variations in the occurrence of cocaine and benzoylecgonine in waste- and surface water from Belgium and removal during wastewater treatment. Water Res 2009, 43:1341-1349.
70. van Nuijs A.L.N., Mougel J.F., Tarcomnicu I., Bervoets L., Blust R., Jorens P.G., et al. A one year investigation of the occurrence of illicit drugs in wastewater from Brussels, Belgium. J Environ Monit 2011, 13:1008-1016.
71. Vázquez-Roig P., Andreu V., Blasco C., Picó Y. SPE and LC-MS/MS determination of 14 illicit drugs in surface waters from the Natural Park of L'Albufera (Valencia, Spain). Anal Bioanal Chem 2010, 397(7):2851-2864.
72. Zeeman M. EPA's framework for ecological effects assessment. Screening and testing chemicals in commerce (OTA-BP-ENV-166) 1995, 169-178. U.S. Congress, Office of Technical Assistance, Washington DC. OTA (Ed.).
73. Zuccato E., Chiabrando C., Castiglioni S., Calamari D., Bagnati R., Chiarea S., et al. Cocaine in surface waters: a new evidence-based tool to monitor community drug abuse. Environ Health 2005, 4:14.
74. Zuccato E., Castiglioni S., Bagnati R., Chiabrando C., Grassi P., Fanelli R. Illicit drugs, a novel group of environmental contaminants. Water Res 2008, 42(4-5):961-968.
75. Zuccato E., Chiabrando C., Castiglioni S., Bagnati R., Fanelli R. Estimating community drug abuse by wastewater analysis. Environ Health Perspect 2008, 116(8):1027-1032.