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Volumn 142, Issue 2, 2014, Pages 222-228

Risk of type 2 diabetes mellitus associated with statin therapy: Evidence and possible mechanisms;Riesgo de diabetes mellitus tipo 2 asociado al uso de estatinas: Evidencias y posibles mecanismos

Author keywords

Diabetes mellitus type 2; Hydroxymethylglutaryl Co A Reductase inhibitors; Insulin resistance

Indexed keywords


EID: 84901939428     PISSN: 00349887     EISSN: 07176163     Source Type: Journal    
DOI: 10.4067/S0034-98872014000200012     Document Type: Review
Times cited : (3)

References (34)
  • 1
    • 0038004785 scopus 로고    scopus 로고
    • Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors
    • Tobert JA. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov 2003; 2 (7): 517-26.
    • (2003) Nat Rev Drug Discov , vol.2 , Issue.7 , pp. 517-526
    • Tobert, J.A.1
  • 2
    • 78651511585 scopus 로고    scopus 로고
    • Clinical implications of pharmacogenetic variation on the effects of statins
    • Maggo SD, Kennedy MA, Clark DW. Clinical implications of pharmacogenetic variation on the effects of statins. Drug Saf 2011; 34 (1): 1-19.
    • (2011) Drug Saf , vol.34 , Issue.1 , pp. 1-19
    • Maggo, S.D.1    Kennedy, M.A.2    Clark, D.W.3
  • 4
    • 0346872978 scopus 로고    scopus 로고
    • Use of statins in primary and secondary prevention of coronary heart disease and ischemic stroke. Meta-analysis of randomized trials
    • Vrecer M, Turk S, Drinovec J, Mrhar A. Use of statins in primary and secondary prevention of coronary heart disease and ischemic stroke. Meta-analysis of randomized trials. Int J Clin Pharmacol Ther 2003; 41 (12): 567-77.
    • (2003) Int J Clin Pharmacol Ther , vol.41 , Issue.12 , pp. 567-577
    • Vrecer, M.1    Turk, S.2    Drinovec, J.3    Mrhar, A.4
  • 5
    • 2342468034 scopus 로고    scopus 로고
    • Metaanalysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes
    • Cheung BM, Lauder IJ, Lau CP, Kumana CR. Metaanalysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes. Br J Clin Pharmacol 2004; 57 (5): 640-51.
    • (2004) Br J Clin Pharmacol , vol.57 , Issue.5 , pp. 640-651
    • Cheung, B.M.1    Lauder, I.J.2    Lau, C.P.3    Kumana, C.R.4
  • 6
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterollowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C, et al. Efficacy and safety of cholesterollowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 2005; 366 (9493): 1267-78.
    • (2005) Lancet , vol.366 , Issue.9493 , pp. 1267-1278
    • Baigent, C.1    Keech, A.2    Kearney, P.M.3    Blackwell, L.4    Buck, G.5    Pollicino, C.6
  • 7
    • 78449281377 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials
    • Cholesterol Treatment Trialists' (CTT) Collaboration
    • Cholesterol Treatment Trialists' (CTT) Collaboration, Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 2010; 376 (9753): 1670-81.
    • (2010) Lancet , vol.376 , Issue.9753 , pp. 1670-1681
    • Baigent, C.1    Blackwell, L.2    Emberson, J.3    Holland, L.E.4    Reith, C.5
  • 8
    • 33846323959 scopus 로고    scopus 로고
    • Estatinas: Eficacia, seguridad e indicaciones
    • Galán M, Taix F, Carrascosa F. Estatinas: eficacia, seguridad e indicaciones. Inf Ter Sist Nac Salud 2004; 28 (4): 89-100.
    • (2004) Inf Ter Sist Nac Salud , vol.28 , Issue.4 , pp. 89-100
    • Galán, M.1    Taix, F.2    Carrascosa, F.3
  • 9
    • 35748962429 scopus 로고    scopus 로고
    • The safety of statins in clinical practice
    • Armitage J. The safety of statins in clinical practice. Lancet 2007; 370 (9601): 1781-90.
    • (2007) Lancet , vol.370 , Issue.9601 , pp. 1781-1790
    • Armitage, J.1
  • 10
    • 0035936527 scopus 로고    scopus 로고
    • Pravastatin and the development of diabetes mellitus: Evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study
    • Freeman DJ, Norrie J, Sattar N, Neely RD, Cobbe SM, Ford I, et al. Pravastatin and the development of diabetes mellitus: evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study. Circulation 2001; 103 (3): 357-62.
    • (2001) Circulation , vol.103 , Issue.3 , pp. 357-362
    • Freeman, D.J.1    Norrie, J.2    Sattar, N.3    Neely, R.D.4    Cobbe, S.M.5    Ford, I.6
  • 11
    • 36249022736 scopus 로고    scopus 로고
    • Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein
    • Ridker PM, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Khurmi NS, et al. Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein. Am J Cardiol 2007; 100 (11): 1659-64.
    • (2007) Am J Cardiol , vol.100 , Issue.11 , pp. 1659-1664
    • Ridker, P.M.1    Fonseca, F.A.2    Genest, J.3    Gotto, A.M.4    Kastelein, J.J.5    Khurmi, N.S.6
  • 12
    • 44349095752 scopus 로고    scopus 로고
    • The effect of statins on the development of new-onset type 2 diabetes: A meta-analysis of randomized controlled trials
    • Coleman CI, Reinhart K, Kluger J, White CM. The effect of statins on the development of new-onset type 2 diabetes: a meta-analysis of randomized controlled trials. Curr Med Res Opin 2008; 24 (5): 1359-62.
    • (2008) Curr Med Res Opin , vol.24 , Issue.5 , pp. 1359-1362
    • Coleman, C.I.1    Reinhart, K.2    Kluger, J.3    White, C.M.4
  • 14
    • 77549087054 scopus 로고    scopus 로고
    • Statins and risk of incident diabetes: A collaborative meta-analysis of randomised statin trials
    • Sattar N, Preiss D, Murray HM, Welsh P, Buckley BM, de Craen AJ, et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet 2010; 375 (9716): 735-42.
    • (2010) Lancet , vol.375 , Issue.9716 , pp. 735-742
    • Sattar, N.1    Preiss, D.2    Murray, H.M.3    Welsh, P.4    Buckley, B.M.5    de Craen, A.J.6
  • 15
    • 79959428660 scopus 로고    scopus 로고
    • Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: A metaanalysis
    • Preiss D, Seshasai SR, Welsh P, Murphy SA, Ho JE, Waters DD, et al. Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a metaanalysis. JAMA 2011; 305 (24): 2556-64.
    • (2011) JAMA , vol.305 , Issue.24 , pp. 2556-2564
    • Preiss, D.1    Seshasai, S.R.2    Welsh, P.3    Murphy, S.A.4    Ho, J.E.5    Waters, D.D.6
  • 16
    • 20444497396 scopus 로고    scopus 로고
    • Pravastatin does not affect insulin sensitivity and adipocytokines levels in healthy nondiabetic patients
    • Gannagé-Yared MH, Azar RR, Amm-Azar M, Khalifé S, Germanos-Haddad M, Neemtallah R, et al. Pravastatin does not affect insulin sensitivity and adipocytokines levels in healthy nondiabetic patients. Metabolism 2005; 54 (7): 947-51.
    • (2005) Metabolism , vol.54 , Issue.7 , pp. 947-951
    • Gannagé-Yared, M.H.1    Azar, R.R.2    Amm-Azar, M.3    Khalifé, S.4    Germanos-Haddad, M.5    Neemtallah, R.6
  • 17
    • 67349224722 scopus 로고    scopus 로고
    • Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients
    • Koh KK, Quon MJ, Han SH, Lee Y, Kim SJ, Park JB, et al. Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients. Atherosclerosis 2009; 204 (2): 483-90.
    • (2009) Atherosclerosis , vol.204 , Issue.2 , pp. 483-490
    • Koh, K.K.1    Quon, M.J.2    Han, S.H.3    Lee, Y.4    Kim, S.J.5    Park, J.B.6
  • 18
    • 79952106340 scopus 로고    scopus 로고
    • Differential metabolic effects of distinct statins
    • Koh KK, Sakuma I, Quon MJ. Differential metabolic effects of distinct statins. Atherosclerosis 2011; 215 (1): 1-8.
    • (2011) Atherosclerosis , vol.215 , Issue.1 , pp. 1-8
    • Koh, K.K.1    Sakuma, I.2    Quon, M.J.3
  • 19
    • 68949196883 scopus 로고    scopus 로고
    • Rosuvastatin treatment is associated with an increase in insulin resistance in hyperlipidaemic patients with impaired fasting glucose
    • Kostapanos MS, Milionis HJ, Agouridis AD, Rizos CV, Elisaf MS. Rosuvastatin treatment is associated with an increase in insulin resistance in hyperlipidaemic patients with impaired fasting glucose. Int J Clin Pract 2009; 63 (9): 1308-13.
    • (2009) Int J Clin Pract , vol.63 , Issue.9 , pp. 1308-1313
    • Kostapanos, M.S.1    Milionis, H.J.2    Agouridis, A.D.3    Rizos, C.V.4    Elisaf, M.S.5
  • 20
    • 79956155395 scopus 로고    scopus 로고
    • Comparative effects of rosuvastatin and atorvastatin on glucose metabolism and adipokine levels in non-diabetic patients with dyslipidaemia: A prospective randomised open-label study
    • Anagnostis P, Selalmatzidou D, Polyzos SA, Panagiotou A, Slavakis A, Panagiotidou A, et al. Comparative effects of rosuvastatin and atorvastatin on glucose metabolism and adipokine levels in non-diabetic patients with dyslipidaemia: a prospective randomised open-label study. Int J Clin Pract 2011; 65 (6): 679-83.
    • (2011) Int J Clin Pract , vol.65 , Issue.6 , pp. 679-683
    • Anagnostis, P.1    Selalmatzidou, D.2    Polyzos, S.A.3    Panagiotou, A.4    Slavakis, A.5    Panagiotidou, A.6
  • 21
    • 73749087527 scopus 로고    scopus 로고
    • Differing effect of statins on insulin sensitivity in non-diabetics: A systematic review and meta-analysis
    • Baker WL, Talati R, White CM, Coleman CI. Differing effect of statins on insulin sensitivity in non-diabetics: a systematic review and meta-analysis. Diabetes Res Clin Pract 2010; 87 (1): 98-107.
    • (2010) Diabetes Res Clin Pract , vol.87 , Issue.1 , pp. 98-107
    • Baker, W.L.1    Talati, R.2    White, C.M.3    Coleman, C.I.4
  • 22
    • 0032104120 scopus 로고    scopus 로고
    • Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance
    • Garvey WT, Maianu L, Zhu JH, Brechtel-Hook G, Wallace P, Baron AD. Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. J Clin Invest 1998; 101 (11): 2377-86.
    • (1998) J Clin Invest , vol.101 , Issue.11 , pp. 2377-2386
    • Garvey, W.T.1    Maianu, L.2    Zhu, J.H.3    Brechtel-Hook, G.4    Wallace, P.5    Baron, A.D.6
  • 23
    • 33745794259 scopus 로고    scopus 로고
    • Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): Implications in glycaemic control
    • Nakata M, Nagasaka S, Kusaka I, Matsuoka H, Ishibashi S, Yada T. Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic control. Diabetologia 2006; 49 (8): 1881-92.
    • (2006) Diabetologia , vol.49 , Issue.8 , pp. 1881-1892
    • Nakata, M.1    Nagasaka, S.2    Kusaka, I.3    Matsuoka, H.4    Ishibashi, S.5    Yada, T.6
  • 24
    • 0027364367 scopus 로고
    • Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins
    • Metz SA, Rabaglia ME, Stock JB, Kowluru A. Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins. Biochem J 1993; 295 (Pt 1): 31-40.
    • (1993) Biochem J , vol.295 , Issue.PART 1 , pp. 31-40
    • Metz, S.A.1    Rabaglia, M.E.2    Stock, J.B.3    Kowluru, A.4
  • 25
    • 38849189665 scopus 로고    scopus 로고
    • Distinct effects of pravastatin, atorvastatin, and simvastatin on insulin secretion from a beta-cell line, MIN6 cells
    • Ishikawa M, Okajima F, Inoue N, Motomura K, Kato T, Takahashi A, et al. Distinct effects of pravastatin, atorvastatin, and simvastatin on insulin secretion from a beta-cell line, MIN6 cells. J Atheroscler Thromb 2006; 13 (6): 329-35.
    • (2006) J Atheroscler Thromb , vol.13 , Issue.6 , pp. 329-335
    • Ishikawa, M.1    Okajima, F.2    Inoue, N.3    Motomura, K.4    Kato, T.5    Takahashi, A.6
  • 26
    • 77954272440 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides
    • Abe M, Toyohara T, Ishii A, Suzuki T, Noguchi N, Akiya-ma Y, et al. The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides. Drug Metab Pharmacokinet 2010; 25 (3): 274-82.
    • (2010) Drug Metab Pharmacokinet , vol.25 , Issue.3 , pp. 274-282
    • Abe, M.1    Toyohara, T.2    Ishii, A.3    Suzuki, T.4    Noguchi, N.5    Akiya-ma, Y.6
  • 27
    • 84555189350 scopus 로고    scopus 로고
    • Research on the effect of statins on insulin secretion from pancreatic islet in rats and its mechanisms
    • Chang BC, Zheng MY, Shan CY, Yang JH, Wang Y, Ren HZ, et al. Research on the effect of statins on insulin secretion from pancreatic islet in rats and its mechanisms. Zhonghua Nei Ke Za Zhi 2011; 50 (5): 393-6.
    • (2011) Zhonghua Nei Ke Za Zhi , vol.50 , Issue.5 , pp. 393-396
    • Chang, B.C.1    Zheng, M.Y.2    Shan, C.Y.3    Yang, J.H.4    Wang, Y.5    Ren, H.Z.6
  • 28
    • 0032978644 scopus 로고    scopus 로고
    • Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells
    • Yada T, Nakata M, Shiraishi T, Kakei M. Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells. Br J Pharmacol 1999; 126 (5): 1205-13.
    • (1999) Br J Pharmacol , vol.126 , Issue.5 , pp. 1205-1213
    • Yada, T.1    Nakata, M.2    Shiraishi, T.3    Kakei, M.4
  • 29
    • 66849115296 scopus 로고    scopus 로고
    • Mechanisms of biphasic insulin-granule exocytosis-roles of the cytoskeleton, small GTPases and SNARE proteins
    • Wang Z, Thurmond DC. Mechanisms of biphasic insulin-granule exocytosis-roles of the cytoskeleton, small GTPases and SNARE proteins. J Cell Sci 2009; 122 (Pt 7): 893-903.
    • (2009) J Cell Sci , vol.122 , Issue.PART 7 , pp. 893-903
    • Wang, Z.1    Thurmond, D.C.2
  • 30
    • 24344509230 scopus 로고    scopus 로고
    • Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients
    • Mabuchi H, Higashikata T, Kawashiri M, Katsuda S, Mizuno M, Nohara A, et al. Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients. J Atheroscler Thromb 2005; 12 (2): 111-9.
    • (2005) J Atheroscler Thromb , vol.12 , Issue.2 , pp. 111-119
    • Mabuchi, H.1    Higashikata, T.2    Kawashiri, M.3    Katsuda, S.4    Mizuno, M.5    Nohara, A.6
  • 31
    • 34248195476 scopus 로고    scopus 로고
    • Endogenous synthesis of coenzyme Q in eukaryotes
    • Tran UC, Clarke CF. Endogenous synthesis of coenzyme Q in eukaryotes. Mitochondrion 2007; 7 (Suppl): S62-71.
    • (2007) Mitochondrion , vol.7 , Issue.SUPPL.
    • Tran, U.C.1    Clarke, C.F.2
  • 32
    • 32044435884 scopus 로고    scopus 로고
    • Isoprenylated proteins
    • McTaggart SJ. Isoprenylated proteins. Cell Mol Life Sci 2006; 63 (3): 255-67.
    • (2006) Cell Mol Life Sci , vol.63 , Issue.3 , pp. 255-267
    • McTaggart, S.J.1
  • 33
    • 33847042302 scopus 로고    scopus 로고
    • Dominant-negative alpha-subunit of farnesyl-and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells
    • Veluthakal R, Kaur H, Goalstone M, Kowluru A. Dominant-negative alpha-subunit of farnesyl-and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells. Diabetes 2007; 56 (1): 204-10.
    • (2007) Diabetes , vol.56 , Issue.1 , pp. 204-210
    • Veluthakal, R.1    Kaur, H.2    Goalstone, M.3    Kowluru, A.4
  • 34
    • 77951159949 scopus 로고    scopus 로고
    • Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells
    • Kowluru A, Veluthakal R, Rhodes CJ, Kamath V, Syed I, Koch BJ. Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. Diabetes 2010; 59 (4): 967-77.
    • (2010) Diabetes , vol.59 , Issue.4 , pp. 967-977
    • Kowluru, A.1    Veluthakal, R.2    Rhodes, C.J.3    Kamath, V.4    Syed, I.5    Koch, B.J.6


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