Involvement of nitric oxide (NO) signaling pathway in the antidepressant action of the total flavonoids extracted from Xiaobuxin-Tang

Neuroscience Letters

Volumn 575, Issue , 2014, Pages 31-36

  Zhang, Li Ming ^a   Wang, Heng Lin ^b   Zhao, Nan ^a   Chen, Hong Xia ^a   Li, Yun Feng ^a   Zhang, You Zhi ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b 309TH HOSPITAL OF PLA   (China)

Author keywords

Antidepressant like effect; Forced swim test; Nitric oxide; Xiaobuxin Tang

Indexed keywords

7 NITROINDAZOLE; AMINOGUANIDINE; ARGININE; FLAVONOID; HERBACEOUS AGENT; NITRIC OXIDE; UNCLASSIFIED DRUG; XIAOBUXIN TANG; 7-NITROINDAZOLE; ANTIDEPRESSANT AGENT; GUANIDINE DERIVATIVE; INDAZOLE DERIVATIVE; NITRIC OXIDE SYNTHASE; XIAOBUXIN-TANG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DEPRESSION; FORCED SWIM TEST; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MOTOR ACTIVITY; SIGNAL TRANSDUCTION;

ANIMALS; ANTIDEPRESSIVE AGENTS; ARGININE; DRUGS, CHINESE HERBAL; FLAVONOIDS; GUANIDINES; INDAZOLES; MALE; MICE, INBRED ICR; MOTOR ACTIVITY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SIGNAL TRANSDUCTION;

EID: 84901938430     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.04.039     Document Type: Article

References (14)

1. An L., Zhang Y.Z., Liu X.M., Yu N.J., Chen H.X., Zhao N., Yuan L., Li Y.F. Total flavonoids extracted from Xiaobuxin-Tang on the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats. Evid. Based Complement. Altern. Med. 2011, 2011:367619.
2. An L., Zhang Y.Z., Yu N.J., Liu X.M., Zhao N., Yuan L., Chen H.X., Li Y.F. The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2008, 32:1484-1490.
3. An L., Zhang Y.Z., Yu N.J., Liu X.M., Zhao N., Yuan L., Li Y.F. Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang. Pharmacol. Biochem. Behav. 2008, 89:572-580.
4. Breard M., Sari M.A., Frapart Y., Boucher J.L., Ducrocq C., Grillon C. The endogenous neurotransmitter, serotonin, modifies neuronal nitric oxide synthase activities. Free Radic. Res. 2007, 41:413-423.
5. Chrapko W.E., Jurasz P., Radomski M.W., Lara N., Archer S.L., Le Melledo J.M. Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder. Biol. Psychiatry 2004, 56:129-134.
6. Crespi F. The selective serotonin reuptake inhibitor fluoxetine reduces striatal in vivo levels of voltammetric nitric oxide (NO): a feature of its antidepressant activity?. Neurosci. Lett. 2010, 470:95-99.
7. Dhir A., Kulkarni S.K. Nitric oxide and major depression. Nitric Oxide: Biol. Chem./Off. J. Nitric Oxide Soc. 2011, 24:125-131.
8. Finkel M.S., Laghrissi-Thode F., Pollock B.G., Rong J. Paroxetine is a novel nitric oxide synthase inhibitor. Psychopharmacol. Bull. 1996, 32:653-658.
9. Krass M., Wegener G., Vasar E., Volke V. The antidepressant action of imipramine and venlafaxine involves suppression of nitric oxide synthesis. Behav. Brain Res. 2011, 218:57-63.
10. Moreno J., Gaspar E., Lopez-Bello G., Juarez E., Alcazar-Leyva S., Gonzalez-Trujano E., Pavon L., Alvarado-Vasquez N. Increase in nitric oxide levels and mitochondrial membrane potential in platelets of untreated patients with major depression. Psychiatry Res. 2013, 209:447-452.
11. Spiacci A., Kanamaru F., Guimaraes F.S., Oliveira R.M. Nitric oxide-mediated anxiolytic-like and antidepressant-like effects in animal models of anxiety and depression. Pharmacol. Biochem. Behav. 2008, 88:247-255.
12. Yildiz F., Erden B.F., Ulak G., Utkan T., Gacar N. Antidepressant-like effect of 7-nitroindazole in the forced swimming test in rats. Psychopharmacology (Berl) 2000, 149:41-44.
13. Zhang Y.Z., Li Y.F., Yu N.J., Yuan L., Zhao Y.M., Xiao W.B., Luo Z.P. Antidepressant-like effects of the ethanolic extract of Xiaobuxin-Tang, a traditional Chinese herbal prescription in animal models of depression. Chin. Med. J. (Engl.) 2007, 120:1792-1796.
14. Zomkowski A.D., Engel D., Cunha M.P., Gabilan N.H., Rodrigues A.L. The role of the NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of duloxetine in the forced swimming test. Pharmacol. Biochem. Behav. 2012, 103:408-417.