Synthesis of some new 1,2,4-triazole derivatives starting from 3-(4-Chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol with anti-lipase and anti-urease activities

Archiv der Pharmazie

Volumn 347, Issue 6, 2014, Pages 387-397

  Bekircan, Olcay ^a   Menteşe, Emre ^b   Ülker, Serdar ^b   Kucuk, Cagatay ^a  

^a KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

^b RECEP TAYYIP ERDOGAN UNIVERSITY   (Turkey)

Author keywords

1,2,4 Triazoles; Anti urease activities; Lipase inhibition; Mannich bases; Schiff bases

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 2 [3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL] N [(2,4 DICHLOROPHENYL)METHYLENE]ACETOHYDRAZIDE; 2 [3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL] N [(2,4 DIFLUOROPHENYL)METHYLENE]ACETOHYDRAZIDE; 2 [3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL] N [(4 CHLOROPHENYL)METHYLENE]ACETOHYDRAZIDE; 2 [3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL] N [(4 FLUOROPHENYL)METHYLENE]ACETOHYDRAZIDE; 2 [3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL]ACETOHYRAZIDE; 3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL; 4 AMINO 5 [[3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL]METHYL] 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 4 [[4 (2,4 DICHLOROPHENYL)METHYLIDENE]AMINO 5 [[3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL]METHYL] 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 4 [[4 (2,4 DICHLOROPHENYL)METHYLIDENE]AMINO] 2 (4 METHYLPIPERAZIN 1 YL) 5 [[3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL]METHYL] 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 4 [[4 (2,4 DIFLUOROPHENYL)METHYLIDENE]AMINO 5 [[3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL]METHYL] 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 4 [[4 (2,4 DIFLUOROPHENYL)METHYLIDENE]AMINO] 2 (4 METHYLPIPERAZIN 1 YL) 5 [[3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL]METHYL] 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 4 [[4 (4 CHLOROPHENYL)METHYLIDENE]AMINO] 2 (4 METHYLPIPERAZIN 1 YL) 5 [[3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL]METHYL] 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 4 [[4 (CHLOROPHENYL)METHYLIDENE]AMINO 5 [[3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL]METHYL] 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 4 [[4 (FLUOROPHENYL)METHYLIDENE]AMINO 5 [[3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL]METHYL] 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 4 [[4 (FLUOROPHENYL)METHYLIDENE]AMINO] 2 (4 METHYLPIPERAZIN 1 YL) 5 [[3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL]METHYL] 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; ESTERASE INHIBITOR; ETHYL[3 (4 CHLOROPHENYL) 5 (4 METHOXYBENZYL) 4H 1,2,4 TRIAZOL 4 YL]ACETIC ACID; MANNICH BASE; SCHIFF BASE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; UREASE; UREASE INHIBITOR; 1,2,4-TRIAZOLE; ANTIOBESITY AGENT; ENZYME INHIBITOR; LACTONE; TETRAHYDROLIPSTATIN; TRIAZOLE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; CYCLIZATION; DEAMINATION; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG DESIGN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-OBESITY AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; LACTONES; LIPASE; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; UREASE;

EID: 84901917513     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201300344     Document Type: Article

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