Loss of bone strength in response to exercise-induced weight loss in obese postmenopausal women: Results from a pilot study

Journal of Musculoskeletal Neuronal Interactions

Volumn 14, Issue 2, 2014, Pages 229-238

  Shea, K L ^a   Gozansky, W S ^a   Sherk, V D ^a   Swibas, T A ^a   Wolfe, P ^b   Scherzinger, A ^c   Stamm, E ^c   Kohrt, W M ^a  

^a Division of Geriatric Medicine   (United States)

^b Department of Preventative Medicine and Biostatistics ^*  (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Bone mineral density; Bone strength; Exercise; Menopause

Indexed keywords

ARTICLE; BODY MASS; BONE DENSITY; BONE STRENGTH; COMPUTER ASSISTED TOMOGRAPHY; CROSS-SECTIONAL MOMENT OF INERTIA; DUAL ENERGY X RAY ABSORPTIOMETRY; ENDURANCE TRAINING; EXERCISE; FAT MASS; FEMUR; FEMUR NECK; FOLLOW UP; HIP; MUSCULOSKELETAL SYSTEM PARAMETERS; OBESITY; PILOT STUDY; POSTMENOPAUSE; SECTION MODULUS; WEIGHT REDUCTION; AGED; BONE; FEMALE; HUMAN; KINESIOTHERAPY; MIDDLE AGED; PATHOPHYSIOLOGY; PHOTON ABSORPTIOMETRY; PHYSIOLOGY; PROCEDURES; RADIOGRAPHY;

ABSORPTIOMETRY, PHOTON; AGED; BONE AND BONES; BONE DENSITY; EXERCISE; EXERCISE THERAPY; FEMALE; FEMUR NECK; HUMANS; MIDDLE AGED; OBESITY; PILOT PROJECTS; POSTMENOPAUSE; TOMOGRAPHY, X-RAY COMPUTED; WEIGHT LOSS; WEIGHT REDUCTION PROGRAMS;

EID: 84901854892     PISSN: 11087161     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Villareal DT, Chode S, Nehu P, Sinacore DR, Hilton T, Armento-Villareal A, et al. Weight Loss, Exercise, or Both and Physical Function in Obese Older Adults. N Engl J Med 2011;364(13):1218-29.
2. Gozansky WS, Van Pelt RE, Jankowski CM, Schwartz RS, Kohrt WM. Protection of bone mass by estrogens and raloxifene during exercise-induced weight Loss. J Clin Endocrinol Metab 2005;90(1):52-9.
3. Villareal DT, Fontana L, Weiss EP, Racette SB, Steger-May K, Schechtman KB, et al. Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial. Arch Intern Med 2006;166(22):2502-10.
4. Villalon KL, Gozansky WS, Van Pelt RE, Wolfe, P, Jankowski, Schwartz RS, et al. A Losing Battle: Weight Regain Does Not Restore Weight Loss-Induced Bone Loss in Postmenopausal Women. Obesity 2011; doi: 10.1038/oby.2011.263.
5. Park HA, Lee JS, Kuller LH, Cauley JA. Effects of weight control during the menopausal transition on bone mineral density. J Clin Endocrinol Metab 2007; 92(10):3809-15.
6. Bouxsein ML. Bone quality: where do we go from here? Osteoporos Int 2003;14(Suppl 5):S118-27.
7. Lang TF, Li J, Harris ST, Genant HK. Assessment of vertebral bone mineral density using volumetric quantitative CT. J Comput Assist Tomogr 1999;23(1):130-7.
8. Carpenter D, Beaupré GS, Lang TF, Orwoll ES, Carter DR, for the Osteoporotic Fractures in Men (MrOS) Study Group. New QCT Analysis Approach Shows the Importance of Fall Orientation on Femoral Neck Strength. J Bone Miner Res 2005;20:1533-42.
9. Bousson V, Le Bras A, Roqueplan F, Kang Y, Mitton D, Kolta S, et al. Volumetric quantitative computed tomography of the proximal femur: relationships linking geometric and densitometric variables to bone strength. Role for compact bone. Osteoporos Int 2006;17(6):855-64.
10. Turner CH, Robling AG. Designing Exercise Regimens to Increase Bone Strength. Exerc. Sport Sci Rev 2003; 31(1):45-50.
11. Hirano T, Burr DB, Turner CH, Sato M, Cain RL, Hock JM. Anabolic effects of human biosynthetic parathyroid hormone fragment (1-34), LY333334, on remodeling and mechanical properties of cortical bone in rabbits. J Bone Miner Res 1999;14(4):536-45.
12. Mashiba T, Turner CH, Hirano T, Forwood MR, Johnston CC, Burr DB. Effects of Suppressed Bone Turnover by Bisphosphonates on Microdamage Accumulation and Biomechanical Properties in Clinically Relevant Skeletal Sites in Beagles. Bone 2001;28(5):524-31.
13. Racette SB, Weiss EP, Obert KA, Kohrt WM, Holloszy JO 2001 Modest lifestyle intervention and glucose tolerance in obese African Americans. Obes Res 9:348-355
14. Borggrefe J, Graeff C, Nickelsen TN, Marin F, Gluer CC. Quantitative Computed Tomographic Assessment of the Effects of 24 Months of Teriparatide Treatment on 3D Femoral Neck Bone Distribution, Geometry, and Bone Strength: Results From the EUROFORS Study. J Bone Miner Res 2010;25(3):472-81.
15. Poole KES, Mayhew PM, Rose CM, Brown, JK, Bearcroft PJ, Loveridge N and Reeve J. Changing Structure of the Femoral Neck Across the Adult Female Lifespan. J Bone Miner Res 2009;2593):482-91.
16. Report of a WHO Study Group. Geneva, World Health Organization (WHO). Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: 1994 (WHO Technical Report Series, No. 843).
17. Villareal DT, Kotyk JJ, Armamento-Villareal RC, Kenguva V, Seaman P, Shahar A, Wald MJ, Kleerekoper M, Fontana L. Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long-term calorie restriction with adequate nutrition. Aging Cell 2011;10(1):96-102.
18. Uusi-Rasi K, Rauhio A, Kannus P, Pasanen M, Kukkonen-Harjula K, Fogelholm M and Sievanen H. Threemonth weight reduction does not compromise bone strength in obse premenopausal women. Bone 2010; 46:1286-93.
19. Kelley, Ga, Kelley KS and Kohrt WM. Effects of ground and joint reaction force exercise on lumbar spine and femoral neck bone mineral density in postmenopausal women: a metaanalysis of randcomized control trials. BMC Musculoskeletal Disorders 2012;13:177.
20. Barry DW, Kohrt WM. Exercise and the Preservation of Bone Health. J Cardiopulm Rehabil Prev 2008; 28(3):153-62.
21. Kohrt WM, Barry DW and Schwartz RS. Muscle Forces or Gravity: What Predominates Mechanical Loading on Bone? Medcine & Science in Sports and Exercise 2009; 41(11):2050-5.
22. Engelke K, Libanati C, Fuerst T, Zysset P, Genant HK. Advanced Ct based In Vivo Methods for the Assessment of Bone Density, Structure, and Strength. Curr Osteoporos Rep 2013; [Epub ahead of print].
23. Sukumar D, Ambia-Sobhan H, Zurfluh R, Schlussel Y, Stahl TJ, Gordon CL, Shapses SA. Areal and volumetric bone mineral density and geometry at two levels of protein intake during caloric restriction: a randomized, controlled trial. Journal of Bone and Mineral Research 2011; 26(6):1339-48.