Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 22, 2014, Pages 8161-8166

  Khokhlova, Tatiana D ^a,b   Wang, Yak Nam ^b   Simon, Julianna C ^b   Cunitz, Bryan W ^b   Starr, Frank ^b   Paun, Marla ^b   Crum, Lawrence A ^b   Bailey, Michael R ^b   Khokhlova, Vera A ^b,c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONNECTIVE TISSUE; ERYTHROCYTE; EX VIVO STUDY; FEASIBILITY STUDY; FRACTIONATION; GREAT BLOOD VESSEL; HIGH INTENSITY FOCUSED ULTRASOUND; LIVER; NONHUMAN; PORCINE MODEL; PRIORITY JOURNAL; TISSUE STRUCTURE; TREATMENT PLANNING; ULTRASOUND GUIDED TISSUE FRACTIONATION;

ANIMALS; ERYTHROCYTES; HIGH-INTENSITY FOCUSED ULTRASOUND ABLATION; LIVER; LIVER CIRCULATION; LUNG; MODELS, ANIMAL; SUBCELLULAR FRACTIONS; SUS SCROFA; TRANSDUCERS; ULTRASONIC THERAPY;

EID: 84901849374     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1318355111     Document Type: Article

References (24)

1. Dubinsky TJ, Cuevas C, Dighe MK, Kolokythas O, Hwang JH (2008) High-intensity focused ultrasound: Current potential and oncologic applications. AJR Am J Roentgenol 190(1):191-199.
2. Bailey MR, Khokhlova VA, Sapozhnikov OA, Kargl SG, Crum LA (2003) Physical mechanisms of the therapeutic effect of ultrasound (a review). Acoust Phys 49: 369-388. (Pubitemid 37056472)
3. Leslie T, et al. (2012) High-intensity focused ultrasound treatment of liver tumours: Post-treatment MRI correlates well with intra-operative estimates of treatment volume. Br J Radiol 85(1018):1363-1370.
4. Crouzet S, et al. (2014) Whole-gland ablation of localized prostate cancer with high-intensity focused ultrasound: Oncologic outcomes and morbidity in 1002 patients. Eur Urol 65(5):907-914.
5. Ren XL, et al. (2007) Extracorporeal ablation of uterine fibroids with high-intensity focused ultrasound: Imaging and histopathologic evaluation. J Ultrasound Med 26(2): 201-212.
6. Khokhlova TD, Hwang JH (2011) HIFU for palliative treatment of pancreatic cancer. J Gastrointest Oncol 2(3):175-184.
7. Elias WJ, et al. (2013) A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med 369(7):640-648.
8. Jolesz FA, Hynynen K, McDannold N, Tempany C (2005) MR imaging-controlled focused ultrasound ablation: A noninvasive image-guided surgery. Magn Reson Imaging Clin N Am 13(3):545-560. (Pubitemid 41111808)
9. Etame AB, et al. (2012) Focused ultrasound disruption of the blood-brain barrier: A new frontier for therapeutic delivery in molecular neurooncology. Neurosurg Focus 32(1):E3.
10. Mo S, Coussios CC, Seymour L, Carlisle R (2012) Ultrasound-enhanced drug delivery for cancer. Expert Opin Drug Deliv 9(12):1525-1538.
11. Khokhlova TD, et al. (2011) Controlled tissue emulsification produced by high intensity focused ultrasound shock waves and millisecond boiling. J Acoust Soc Am 130(5):3498-3510.
12. Canney MS, Khokhlova VA, Bessonova OV, Bailey MR, Crum LA (2010) Shock-induced heating and millisecond boiling in gels and tissue due to high intensity focused ultrasound. Ultrasound Med Biol 36(2):250-267.
13. Wang YN, Khokhlova T, Bailey M, Hwang JH, Khokhlova V (2013) Histological and biochemical analysis of mechanical and thermal bioeffects in boiling histotripsy lesions induced by high intensity focused ultrasound. Ultrasound Med Biol 39(3): 424-438.
14. Simon JC, et al. (2012) Ultrasonic atomization of tissue and its role in tissue fractionation by high intensity focused ultrasound. Phys Med Biol 57(23):8061-8078.
15. Parsons JE, Cain CA, Abrams GD, Fowlkes JB (2006) Pulsed cavitational ultrasound therapy for controlled tissue homogenization. Ultrasound Med Biol 32(1):115-129. (Pubitemid 41814867)
16. Roberts WW, et al. (2006) Pulsed cavitational ultrasound: A noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney. J Urol 175(2):734-738. (Pubitemid 43067440)
17. Hall TL, et al. (2009) Histotripsy of the prostate: Dose effects in a chronic canine model. Urology 74(4):932-937.
18. Vlaisavljevich E, et al. (2013) Image-guided non-invasive ultrasound liver ablation using histotripsy: Feasibility study in an in vivo porcine model. Ultrasound Med Biol 39(8):1398-1409.
19. Yuldashev PV, et al. (2013) Characterization of a multi-element clinical HIFU system using acoustic holography and nonlinear modeling. IEEE Trans. Ultrason. Ferr. Freq. Control. 60:1683-1698.
20. Maxwell A, et al. (2012) Disintegration of tissue using high intensity focused ultrasound: Two approaches that utilize shock waves. Acoustics Today 8(12):24-37.
21. Hill CR, Bamber JC, ter Haar G (2004) Physical Principles of Medical Ultrasonics (Wiley, West Sussex, UK), Chap 9, 2nd Ed.
22. Evan AP, Willis LR, Lingeman JE, McAteer JA (1998) Renal trauma and the risk of long-term complications in shock wave lithotripsy. Nephron 78(1):1-8. (Pubitemid 28014452)
23. Vlaisavljevich E, et al. (2014) Effects of tissue mechanical properties on susceptibility to histotripsy-induced tissue damage. Phys Med Biol 59(2):253-270.
24. Date RS, et al. (2005) Development and validation of an experimental model for the assessment of radiofrequency ablation of pancreatic parenchyma. Pancreas 30(3): 266-271. (Pubitemid 40397380)