Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection

European Journal of Immunology

Volumn 44, Issue 6, 2014, Pages 1710-1715

  Mittrücker, Hans Willi ^a,b   Seidel, Daniel ^c   Bland, Paul W ^d   Zarzycka, Agnieszka ^e   Kaufmann, Stefan H E ^a   Visekruna, Alexander ^e   Steinhoff, Ulrich ^a,e  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Innate immunity; Listeria infection; Memory T cells; Microbiota

Indexed keywords

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CONTROLLED STUDY; GERMFREE ANIMAL; INFECTION RESISTANCE; INNATE IMMUNITY; LETHAL DOSE; LISTERIA MONOCYTOGENES; LISTERIOSIS; MACROPHAGE; MEMORY T LYMPHOCYTE; MICROFLORA; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SECONDARY INFECTION; SURVIVAL;

INNATE IMMUNITY; LISTERIA INFECTION; MEMORY T CELLS; MICROBIOTA;

ADAPTIVE IMMUNITY; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; IMMUNITY, INNATE; IMMUNOLOGIC MEMORY; INTESTINES; LISTERIA MONOCYTOGENES; LISTERIOSIS; MICE; MICROBIOTA;

EID: 84901833029     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201343927     Document Type: Article

References (22)

1. Yamanaka, T., Helgeland, L., Farstad, I. N., Fukushima, H., Midtvedt, T. and Brandtzaeg, P., Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches. J. Immunol. 2003. 170: 816-822.
2. Anderson, K. V., Toll signaling pathways in the innate immune response. Curr. Opin. Immunol. 2000. 12: 13-19.
3. Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. and Medzhitov, R., Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004. 118: 229-241.
4. Mazmanian, S. K., Liu, C. H., Tzianabos, A. O. and Kasper, D. L., An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005. 122: 107-118.
5. Anderlik, P., Szeri, I., Banos, Z. and Barna, Z., Effect of Mannozym on the course of LCMV infection in mice with undeveloped and normal immune system. Acta. Microbiol. Hung. 1992. 39: 3-11.
6. Fox, J. G., Lee, A., Otto, G., Taylor, N. S. and Murphy, J. C., Helicobacter felis gastritis in gnotobiotic rats: an animal model of Helicobacter pylori gastritis. Infect. Immun. 1991. 59: 785-791.
7. Nardi, R. M., Silva, M. E., Vieira, E. C., Bambirra, E. A. and Nicoli, J. R., Intragastric infection of germfree and conventional mice with Salmonella typhimurium. Braz. J. Med. Biol. Res. 1989. 22: 1389-1392.
8. Yale, C. E. and Balish, E., The relative lethality of intestinal bacteria for gnotobiotic rats with experimental intestinal strangulation. J. Med. 1992. 23: 265-277.
9. Inagaki, H., Suzuki, T., Nomoto, K. and Yoshikai, Y., Increased susceptibility to primary infection with Listeria monocytogenes in germfree mice may be due to lack of accumulation of L-selectin+ CD44+ T cells in sites of inflammation. Infect. Immun. 1996. 64: 3280-3287.
10. Rogers, H. W. and Unanue, E. R., Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice. Infect. Immun. 1993. 61: 5090-5096.
11. North, R. J., The relative importance of blood monocytes and fixed macrophages to the expression of cell-mediated immunity to infection. J. Exp. Med. 1970. 132: 521-534.
12. Wing, E. J. and Gregory, S. H., Listeria monocytogenes: clinical and experimental update. J. Infect. Dis. 2002. 185(Suppl 1): S18-S24.
13. Karmarkar, D. and Rock, K. L., Microbiota signaling through MyD88 is necessary for a systemic neutrophilic inflammatory response. Immunology 2013. 140: 483-492.
14. Cebra, C. K., Cebra, M. L. and Ikede, B. O., Congenital joint laxity and disproportionate dwarfism in a herd of beef cattle. J. Am. Vet. Med. Assoc. 1999. 215: 519-521, 483.
15. Williams, A. M., Probert, C. S., Stepankova, R., Tlaskalova-Hogenova, H., Phillips, A. and Bland, P. W., Effects of microflora on the neonatal development of gut mucosal T cells and myeloid cells in the mouse. Immunology 2006. 119: 470-478.
16. Mazmanian, S. K., Round, J. L. and Kasper, D. L., A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 2008. 453: 620-625.
17. Foulds, K. E., Zenewicz, L. A., Shedlock, D. J., Jiang, J., Troy, A. E. and Shen, H., Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses. J. Immunol. 2002. 168: 1528-1532.
18. Kursar, M., Kohler, A., Kaufmann, S. H. and Mittrucker, H. W., Depletion of CD4+ T cells during immunization with nonviable Listeria monocytogenes causes enhanced CD8+ T cell-mediated protection against listeriosis. J. Immunol. 2004. 172: 3167-3172.
19. Kursar, M., Mittrucker, H. W., Koch, M., Kohler, A., Herma, M. and Kaufmann, S. H., Protective T cell response against intracellular pathogens in the absence of Toll-like receptor signaling via myeloid differentiation factor 88. Int. Immunol. 2004. 16: 415-421.
20. Steinhoff, U., Brinkmann, V., Klemm, U., Aichele, P., Seiler, P., Brandt, U., Bland, P. W. et al., Autoimmune intestinal pathology induced by hsp60-specific CD8 T cells. Immunity 1999. 11: 349-358.
21. Mittrucker, H. W., Kursar, M., Kohler, A., Yanagihara, D., Yoshinaga, S. K. and Kaufmann, S. H., Inducible costimulator protein controls the protective T cell response against Listeria monocytogenes. J. Immunol. 2002. 169: 5813-5817.
22. Rao, K. M., Padmanabhan, J., Kilby, D. L., Cohen, H. J., Currie, M. S. and Weinberg, J. B., Flow cytometric analysis of nitric oxide production in human neutrophils using dichlorofluorescein diacetate in the presence of a calmodulin inhibitor. J. Leukoc. Biol. 1992. 51: 496-500.