The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism

Journal of Nutritional Biochemistry

Volumn 25, Issue 7, 2014, Pages 734-740

  Park, Kyungho ^a,b,c   Kim, Young Il ^a,b,c   Shin, Kyong Oh ^d   Seo, Ho Seong ^e   Kim, Jong Youl ^a,b,c   Mann, Taj ^a,b,c   Oda, Yuko ^a,b,c   Lee, Yong Moon ^d   Holleran, Walter M ^a,b,c   Elias, Peter M ^a,b,c   Uchida, Yoshikazu ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION   (United States)

^d Chungbuk National University   (South Korea)

^e Korea Atomic Energy Research Institute   (South Korea)

Author keywords

Cathelicidin antimicrobial peptide; Estrogen receptor ; Genistein; Innate immunity; Keratinocytes

Indexed keywords

ALKALINE CERAMIDASE; CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE; CCAAT ENHANCER BINDING PROTEIN ALPHA; ESTROGEN; FULVESTRANT; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; POLYPEPTIDE ANTIBIOTIC AGENT; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; CERAMIDASE; ESTRADIOL; ESTROGEN RECEPTOR BETA; LYSOPHOSPHOLIPID; OXAZOLE DERIVATIVE; PHENOL DERIVATIVE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; WAY 200070;

ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; INNATE IMMUNITY; KERATINOCYTE; PROTEIN EXPRESSION; UPREGULATION; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

CATHELICIDINS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELLS, CULTURED; CERAMIDASES; ESTRADIOL; ESTROGEN RECEPTOR BETA; GENISTEIN; HUMANS; KERATINOCYTES; LYSOPHOSPHOLIPIDS; OXAZOLES; PHENOLS; RECEPTORS, CALCITRIOL; SPHINGOSINE;

EID: 84901820584     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2014.03.005     Document Type: Article

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