Frequent occurrence of cytomegalovirus retinitis during immune reconstitution warrants regular ophthalmic screening in high-risk pediatric allogeneic hematopoietic stem cell transplant recipients

Clinical Infectious Diseases

Volumn 58, Issue 12, 2014, Pages 1700-1706

  Hiwarkar, Prashant ^a,c   Gajdosova, Eva ^b   Qasim, Waseem ^a,b   Worth, Austen ^a,b   Breuer, Judith ^b   Chiesa, Robert ^c   Ridout, Deborah ^a   Edelsten, Clive ^b   Moore, Anthony ^b   Amrolia, Persis ^a,c   Veys, Paul ^a,c   Rao, Kanchan ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^c Hospital for Children   (United Kingdom)

Author keywords

CMV retinitis, paediatric HSCT; Cytomegalovirus (CMV); ophthalmic screening

Indexed keywords

CORTICOSTEROID;

ADOLESCENT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CHILD; CYTOMEGALOVIRUS INFECTION; CYTOMEGALOVIRUS RETINITIS; FEMALE; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HIGH RISK PATIENT; HUMAN; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; OPHTHALMOLOGIST; OUTPATIENT; PEDIATRIC SURGERY; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; RETINA EXAMINATION; RETROSPECTIVE STUDY; SCHOOL CHILD; VIREMIA; ALLOTRANSPLANTATION; CD4 LYMPHOCYTE COUNT; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; INFANT; MASS SCREENING; NEWBORN; OPHTHALMOLOGY; RISK FACTOR; VIROLOGY; VIRUS LOAD;

ADOLESCENT; CD4 LYMPHOCYTE COUNT; CHILD; CHILD, PRESCHOOL; CYTOMEGALOVIRUS RETINITIS; FEMALE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INFANT; INFANT, NEWBORN; MALE; MASS SCREENING; OPHTHALMOLOGY; RETROSPECTIVE STUDIES; RISK FACTORS; TRANSPLANTATION, HOMOLOGOUS; VIRAL LOAD; VIREMIA;

EID: 84901796507     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/ciu201     Document Type: Article

References (27)

1. Boeckh M, LeisenringW, Riddell SR, et al. Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity. Blood 2003; 101:407-14.
2. Crippa F, Corey L, Chuang EL, et al. Virological, clinical, and ophthalmologic features of cytomegalovirus retinitis after hematopoietic stem cell transplantation. Clin Infect Dis 2001; 32:214-9.
3. Müller M, Wandel S, Colebunders R, et al. Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: A systematic review and meta-analysis. Lancet Infect Dis 2010; 10:251-61.
4. Holbrook JT, Colvin R, van Natta ML, et al., Studies of Ocular Complications of AIDS (SOCA) Research Group. Evaluation of the United States public health service guidelines for discontinuation of anticytomegalovirus therapy after immune recovery in patients with cytomegalovirus retinitis. Am J Ophthalmol 2011; 152:628-37.
5. Patel SR, Ridwan RU, Ortín M. Cytomegalovirus reactivation in pediatric hemopoietic progenitors transplant: A retrospective study on the risk factors and the efficacy of treatment. J Pediatr Hematol Oncol 2005; 27:411-5.
6. Yoon HS, Lee JH, Choi ES, et al. Cytomegalovirus infection in children who underwent hematopoietic stem cell transplantation at a single center: A retrospective study of the risk factors. Pediatr Transplant 2009; 13:898-905.
7. Nichols WG, Corey L, Gooley T, et al. Rising pp65 antigenemia during preemptive anticytomegalovirus therapy after allogeneic hematopoietic stem cell transplantation: risk factors, correlation with DNA load, and outcomes. Blood 2001; 97:867-74.
8. Gor D, Sabin C, Prentice HG, et al. Longitudinal fluctuations in cytomegalovirus load in bone marrow transplant patients: relationship between peak virus load, donor/recipient serostatus, acute GVHD and CMV disease. Bone Marrow Transplant 1998; 21:597-605.
9. Ljungman P, Griffiths P, Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 2002; 34:1094-7.
10. Karlsson H, Brewin J, Kinnon C, et al. Generation of trispecific cytotoxic T cells recognizing cytomegalovirus, adenovirus, and Epstein-Barr virus: an approach for adoptive immunotherapy of multiple pathogens. J Immunother 1997; 30:544-56.
11. Przepiorka D, Weisdorf D, Martin P, et al. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant 1995; 15:825-8.
12. Shulman HM, Sullivan KM,Weiden PL, et al. Chronic graft-versus-host syndrome in man: A long-term clinicopathologic study of 20 Seattle patients. Am J Med 1980; 69:204-17.
13. Xhaard A, Robin M, Scieux C, et al. Increased incidence of cytomegalovirus retinitis after allogeneic hematopoietic stem cell transplantation. Transplantation 2007; 83:80-3.
14. Leeamornsiri S, Choopong P, Tesavibul N. Frosted branch angiitis as a result of immune recovery uveitis in a patient with cytomegalovirus retinitis. J Ophthalmic Inflamm Infect 2013; 22;3:52.
15. Hartigan-O'Connor DJ, Jacobson MA, Tan QX, et al., Studies of Ocular Complications of AIDS Research Group. Development of cytomegalovirus (CMV) immune recovery uveitis is associated with Th17 cell depletion and poor systemic CMV-specific T cell responses. Clin Infect Dis 2011; 52:409-17.
16. Holland GN, Vaudaux JD, Shiramizu KM, et al. Southern California HIV/Eye Consortium. Characteristics of untreated AIDS-related cytomegalovirus retinitis. II. Findings in the era of highly active antiretroviral therapy (1997 to 2000). Am J Ophthalmol 2008; 145:12-22.
17. Nguyen QD, Kempen JH, Bolton SG, et al. Immune recovery uveitis in patients with AIDS and cytomegalovirus retinitis after highly active antiretroviral therapy. Am J Ophthalmol 2000; 129:634-9.
18. Karavellas MP, Plummer DJ, Macdonald JC, et al. Incidence of immune recovery vitritis in cytomegalovirus retinitis patients following institution of successful highly active antiretroviral therapy. J Infect Dis 1999; 179:697-700.
19. Robinson MR, Reed G, Csaky KG, et al. Immune-recovery uveitis in patients with cytomegalovirus retinitis taking highly active antiretroviral therapy. Am J Ophthalmol 2000; 130:49-56.
20. Karavellas MP, Song M, Macdonald JC, et al. Long-term posterior and anterior segment complications of immune recovery uveitis associated with cytomegalovirus retinitis. Am J Ophthalmol 2000; 130:57-64.
21. Kempen JH, Min YI, Freeman WR, et al. Risk of immune recovery uveitis in patients with AIDS and cytomegalovirus retinitis. Ophthalmology 2006; 113:684-94.
22. Morrison VL, Kozak I, LaBree LD, et al. Intravitreal triamcinolone acetonide for the treatment of immune recovery uveitis macular edema. Ophthalmology 2007; 114:334-9.
23. El-Bradey M, Cheng L, Song M, et al. Long term results of treatment of macular complications in eyes with immune recovery uveitis using a graded treatment approach. Retina 2004; 24:376-82.
24. Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. Available at: http://aidsinfo.nih.gov/contentfiles/lvguidelines/adult-oi.pdf. Accessed 16 November 2013.
25. Henderson HW, Mitchell SM. Treatment of immune recovery vitritis with local steroids. Br J Ophthalmol 1999; 83:540-5.
26. Ufret-Vincenty RL, Singh RP, Lowder CY, et al. Cytomegalovirus retinitis after fluocinolone acetonide implant. Am J Ophthalmol 2007; 143:334-5.
27. Jeon S, Lee WK, Lee Y, et al. Risk factors for cytomegalovirus retinitis in patients with cytomegalovirus viremia after hematopoietic stem cell transplantation. Ophthalmology 2012; 119:1892-8.