Function of two arginine residues of L-lactate oxidase

International Congress Series

Volumn 1233, Issue C, 2002, Pages 69-75

  Yorita, Kazuko ^a   Misaki, Hideo ^b   Matsumoto, Mitsuru ^a   Massey, Vincent ^c  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b ASAHI KASEI CORPORATION   (Japan)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

8 Formylflavin; Aerococcus viridans; Arginine residues; Kinetics; L Lactate oxidase

Indexed keywords

EID: 84901788627     PISSN: 05315131     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0531-5131(02)00621-0     Document Type: Article

References (5)

1. Yorita, K., Janko, K., Aki, K., Ghisla, S., Palfey, B.A., Massey, V., On the reaction mechanism of L-lactate oxidase: quantitative structure–activity analysis of the reaction with para-substituted L-mandelate. Proc. Natl. Acad. Sci. U. S. A. 94:18 (1997), 9590–9595.
2. Maeda-Yorita, K., Aki, K., Sagai, H., Misaki, H., Massey, V., L-Lactate oxidase and L-lactate monooxygenase: mechanistic variations on a common structural theme. Biochimie 77:7–8 (1995), 631–642.
3. Yorita, K., Aki, K., Ohkuma-Soyejima, T., Kokubo, T., Misaki, H., Massey, V., Conversion of L-lactate oxidase to a long chain α-hydroxyacid oxidase by site-directed mutagenesis of alanine 95 to glycine. J. Biol. Chem. 271:45 (1996), 28300–28305.
4. Yorita, K., Matsuoka, T., Misaki, H., Massey, V., Interaction of two arginine residues in lactate oxidase with the enzyme flavin; conversion of FMN to 8-formyl-FMN. Proc. Natl. Acad. Sci. U. S. A. 97:24 (2000), 13039–13044.
5. Edmondson, D.E., Intramolecular hemiacetal formation in 8-formylriboflavine. Biochemistry 13:14 (1974), 2817–2821.