On the reaction mechanism of L-lactate oxidase: Quantitative structure-activity analysis of the reaction with para-substituted L-mandelates

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 18, 1997, Pages 9590-9595

  Yorita, Kazuko ^a   Janko, Karl ^b   Aki, Kenji ^a   Ghisla, Sandro ^b   Palfey, Bruce A ^c   Massey, Vincent ^c  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; LACTATE 2 MONOOXYGENASE; MANDELIC ACID DERIVATIVE; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

BINDING SITES; MANDELIC ACIDS; MIXED FUNCTION OXYGENASES; MUTATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 0030886160     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.18.9590     Document Type: Article

References (32)

1. Ghisla, S. & Massey, V. (1991) in Chemistry and Biochemistry of Flavoenzymes, ed. Müller, F. (CRC, Boca Raton, FL), Vol. 2, pp. 243-289.
2. Lederer, F. (1991) in Chemistry and Biochemistry of Flavoenzymes, ed. Müller, F. (CRC, Boca Raton, FL), Vol. 2, pp. 153-242.
3. Lindqvist, Y., Branden, C. I., Mathews, F. S. & Lederer, F. (1991) J. Biol. Chem. 266, 3198-3207.
4. Xia, Z. X. & Mathews, F. S. (1990) J. Mol. Biol. 212, 837-863.
5. Stenberg, K. & Lindqvist, Y. (1997) Protein Sci. 6, 1009-1015.
6. Volokita, M. & Somerville, C. R. (1987) J. Biol. Chem. 262, 15825-15828.
7. Tsugeki, R., Hara-Nishimura, I., Mori, H. & Nishimura, M. (1993) Plant Cell. Physiol. 34, 51-57.
8. Lederer, F., Cortial, S., Becam, A. M., Haumont, P. Y. & Perez, L. (1985) Eur. J. Biochem. 152, 419-428.
9. Giegel, D. A., Williams, C. H., Jr., & Massey, V. (1990) J. Biol. Chem. 265, 6626-6632.
10. Maeda-Yorita, K., Aki, K., Sagai, H., Misaki, H. & Massey, V. (1995) Biochimie 77, 631-642.
11. Le, K. H. D. & Lederer, F. (1992) J. Biol. Chem. 266, 20877-20881.
12. Tsou, A. Y., Ramsom, S. C., Gerlt, J. A., Buechter, D. D., Babbitt, P. C. & Kenyon, G. L. (1990) Biochemistry 29, 9856-9862.
13. Smekal, O., Yasin, M., Fewson, C. A., Reid, G. A. & Chapman, S. K. (1993) Biochem. J. 290, 103-107.
14. Mattevi, A., Vanoni, M. A., Todone, F., Rizzi, M., Teplyakov, A., Coda, A., Bolognesi, M. & Curti, B. (1996) Proc. Natl. Acad. Sci. USA 93, 7496-7501.
15. Pollegioni, L., Blodig, W. & Ghisla, S. (1997) J. Biol. Chem. 272, 4924-4934.
16. Smekal, O., Reid, G. A. & Chapman, S. K. (1994) Biochem. J. 297, 647-652.
17. Yorita, K., Aki, K., Ohkuma-Soejima, T., Kokubo, T., Misaki, H. & Massey, V. (1996) J. Biol. Chem. 271, 28300-28305.
18. Eliason, R., Platz, J. & Calsen, P. H. J. (1991) Acta Chem. Scand. 45, 491-493.
19. Hoover, J. R. E., Dunn, G. L., Jakas, D. R., Lam, L. L., Taggart, J. J., Guarini, J. R. & Phillips, L. (1974) J. Med. Chem. 17, 34-41.
20. Compere, E. L. (1968) J. Org. Chem. 33, 2565-2566.
21. Belcher, R., Sykes, H. & Tatlow, J. C. (1954) Anal. Chim. Acta 10, 34-47.
22. Neilson, D. G., Zakir, V. & Scrimgeour, C. M. (1971) J. Chem. Soc., 898-904.
23. Landro, J. A., Kallarakal, A. T., Ransom, S. C., Gerlt, J. A., Kozarich, J. W., Neidhart, D. J. & Kenyon, G. L. (1991) Biochemistry 30, 9274-9281.
24. Strickland, S., Palmer, G. & Massey, V. (1975) J. Biol. Chem. 250, 4048-4052.
25. March, J. (1992) Advanced Organic Chemistry (Wiley, New York), 4th Ed., Chapt. 9.
26. Hartman, C. & Klinman, J. P. (1991) Biochemistry 30, 4605-4611.
27. Walker, M. C. & Edmondson, D. E. (1994) Biochemistry 33, 7078-7098.
28. Dubois, J., Chapman, S. K., Reid, G. A. & Lederer, F. (1989) Biochemistry 29, 6393-6400.
29. Charton, M. (1975) J. Am. Chem. Soc. 97, 1552-1556.
30. Peitsch, M. C. (1996) Biochem. Soc. Trans. 24, 274-279.
31. Gerlt, J. A. & Gassman, P. G. (1993) Biochemistry 32, 11943-11952.
32. Ghisla, S. (1982) in Flavins and Flavoproteins, eds. Massey, V. & Williams, C. H., Jr. (Elsevier/North-Holland, New York), pp. 133-142.