Solid phase assay for comparing reactivation rates of neuraminidases of influenza wild type and resistant mutants after inhibitor removal

Antiviral Research

Volumn 108, Issue 1, 2014, Pages 30-35

  Barrett, Susan ^a   McKimm Breschkin, Jennifer L ^a  

^a CSIRO   (Australia)

Author keywords

Drug resistance; Influenza; Mutants; Neuraminidase inhibitors; Reactivation

Indexed keywords

OSELTAMIVIR; PERAMIVIR; VIRUS SIALIDASE; ZANAMIVIR; CYCLOPENTANE DERIVATIVE; ENZYME INHIBITOR; GUANIDINE DERIVATIVE; MUTANT PROTEIN; NA PROTEIN, INFLUENZA A VIRUS; NA PROTEIN, INFLUENZA B VIRUS; PROTEIN BINDING; SIALIDASE; VIRUS PROTEIN;

AMNION FLUID; ARTICLE; ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; DISSOCIATION; DRUG BINDING; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REACTIVATION; IC 50; INFLUENZA VIRUS; INFLUENZA VIRUS A; INFLUENZA VIRUS A H5N1; INFLUENZA VIRUS B; KINETICS; NONHUMAN; PRIORITY JOURNAL; REACTION TIME; SOLID PHASE ASSAY; VIRUS MUTANT; VIRUS MUTATION; WILD TYPE; ANTAGONISTS AND INHIBITORS; ENZYMOLOGY; METABOLISM; ORTHOMYXOVIRUS;

CYCLOPENTANES; ENZYME INHIBITORS; GUANIDINES; KINETICS; MUTANT PROTEINS; NEURAMINIDASE; ORTHOMYXOVIRIDAE; OSELTAMIVIR; PROTEIN BINDING; VIRAL PROTEINS; ZANAMIVIR;

EID: 84901782819     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2014.05.006     Document Type: Article

References (23)

1. S. Bantia, C.S. Arnold, C.D. Parker, R. Upshaw, and P. Chand Anti-influenza virus activity of peramivir in mice with single intramuscular injection Antiviral Res. 69 2006 39 45 (Pubitemid 41790480)
2. S. Bantia, R. Upshaw, and Y.S. Babu Characterization of the binding affinities of peramivir and oseltamivir carboxylate to the neuraminidase enzyme Antiviral Res. 91 2011 289 291
3. S. Barrett, P.G. Mohr, P.M. Schmidt, and J.L. McKimm-Breschkin Real time enzyme inhibition assays provide insights into differences in binding of neuraminidase inhibitors to wild type and mutant influenza viruses PLoS One 6 2011 e23627
4. E.Z. Baum, P.C. Wagaman, L. Ly, I. Turchi, J. Le, D. Bucher, and K. Bush A point mutation in influenza B neuraminidase confers resistance to peramivir and loss of slow binding Antiviral Res. 59 2003 13 22 (Pubitemid 36773886)
5. T.J. Blick, T. Tiong, A. Sahasrabudhe, J.N. Varghese, P.M. Colman, G.J. Hart, R.C. Bethell, and J.L. McKimm-Breschkin Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en Virology 214 1995 475 484 (Pubitemid 26027775)
6. A.C. Hurt, P. Iannello, K. Jachno, N. Komadina, A.W. Hampson, I.G. Barr, and J.L. McKimm-Breschkin Neuraminidase inhibitor-resistant and -sensitive influenza B viruses isolated from an untreated human patient Antimicrob. Agents Chemother. 50 2006 1872 1874
7. W.M. Kati, A.S. Saldivar, F. Mohamadi, H.L. Sham, W.G. Laver, and W.E. Kohlbrenner GS4071 is a slow-binding inhibitor of influenza neuraminidase from both A and B strains Biochem. Biophys. Res. Commun. 244 1998 408 413 (Pubitemid 28414096)
8. J.H. Kim, R. Resende, T. Wennekes, H.M. Chen, N. Bance, S. Buchini, A.G. Watts, P. Pilling, V.A. Streltsov, M. Petric, R. Liggins, S. Barrett, J.L. McKimm-Breschkin, M. Niikura, and S.G. Withers Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity Science 340 2013 71 75
9. M. Kiso, S. Kubo, M. Ozawa, Q.M. Le, C.A. Nidom, M. Yamashita, and Y. Kawaoka Efficacy of the new neuraminidase inhibitor CS-8958 against H5N1 influenza viruses PLoS Pathog. 6 2010 e1000786
10. J.L. McKimm-Breschkin Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance Influenza Other Respir. Viruses 7 Suppl. 1 2013 25 36
11. J.L. McKimm-Breschkin, Barrett S. Pudjiatmoko, M. Azhar, F.Y. Wong, P. Selleck, P.G. Mohr, J. McGrane, and M. Kim I222 neuraminidase mutations further reduce oseltamivir5 susceptibility of Indonesian Clade 2.1 highly pathogenic avian influenza A(H5N1) viruses PLoS One 8 2013 e66105
12. J.L. McKimm-Breschkin, C. Rootes, P.G. Mohr, S. Barrett, and V.A. Streltsov In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir J. Antimicrob. Chemother. 67 2012 1874 1883
13. J.L. McKimm-Breschkin, A. Sahasrabudhe, T.J. Blick, M. McDonald, P.M. Colman, G.J. Hart, R.C. Bethell, and J.N. Varghese Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors J. Virol. 72 1998 2456 2462 (Pubitemid 28100807)
14. J.L. McKimm-Breschkin, P. Selleck, T.B. Usman, and M.A. Johnson Reduced sensitivity of influenza A (H5N1) to oseltamivi Emerg. Infect. Dis. 13 2007 1354 1357 www.cdc.gov/eid (Pubitemid 47510297)
15. J.L. McKimm-Breschkin, J. Williams, S. Barrett, K. Jachno, M. McDonald, P.G. Mohr, T. Saito, and M. Tashiro Reduced susceptibility to all neuraminidase inhibitors of influenza H1N1 viruses with haemagglutinin mutations and mutations in non-conserved residues of the neuraminidase J. Antimicrob. Chemother. 68 2013 2210 2221
16. A.S. Monto, J.L. McKimm-Breschkin, C. Macken, A.W. Hampson, A. Hay, A. Klimov, M. Tashiro, R.G. Webster, M. Aymard, F.G. Hayden, and M. Zambon Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their use Antimicrob. Agents Chemother. 50 2006 2395 2402 (Pubitemid 43993177)
17. A.J. Oakley, S. Barrett, T.S. Peat, J. Newman, V.A. Streltsov, L. Waddington, T. Saito, M. Tashiro, and J.L. McKimm-Breschkin Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses J. Med. Chem. 53 2010 6421 6431
18. M.S. Pegg, and M. von Itzstein Slow-binding inhibition of sialidase from influenza virus Biochem. Mol. Biol. Int. 32 1994 851 858 (Pubitemid 24133327)
19. B.J. Smith, J.L. McKimm-Breschkin, M. McDonald, R.T. Fernley, J.N. Varghese, and P.M. Colman Structural studies of the resistance of influenza virus neuramindase to inhibitors J. Med. Chem. 45 2002 2207 2212 (Pubitemid 34525800)
20. M. Tashiro, J.L. McKimm-Breschkin, T. Saito, A. Klimov, C. Macken, M. Zambon, and F.G. Hayden Surveillance for neuraminidase-inhibitor-resistant influenza viruses in Japan, 1996-2007 Antivir. Ther. 14 2009 751 761
21. J.N. Varghese, P.W. Smith, S.L. Sollis, T.J. Blick, A. Sahasrabudhe, J.L. McKimm-Breschkin, and P.M. Colman Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase Structure 6 1998 735 746 (Pubitemid 28301207)
22. M.Z. Wang, C.Y. Tai, and D.B. Mendel Mechanism by which mutations at His274 alter sensitivity of influenza a virus N1 neuraminidase to oseltamivir carboxylate and zanamivir Antimicrob. Agents Chemother. 46 2002 3809 3816 (Pubitemid 35403254)
23. A.G. Watts, P. Oppezzo, S.G. Withers, P.M. Alzari, and A. Buschiazzo Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase J. Biol. Chem. 281 2006 4149 4155 (Pubitemid 43847842)