A novel autoantibody against moesin in the serum of patients with MPO-ANCA-associated vasculitis

Nephrology Dialysis Transplantation

Volumn 29, Issue 6, 2014, Pages 1168-1177

  Suzuki, Kazuo ^a,f   Suzuki, Koya ^a,b,c   Nagao, Tomokazu ^a   Itabashi, Mitsuyo ^d   Hamano, Yoshitomo ^e   Sugamata, Ryuichi ^a   Yamazaki, Yuji ^c   Yumura, Wako ^e   Tsukita, Sachiko ^c   Wang, Pi Chao ^b   Nakayama, Toshinori ^a  

^a CHIBA UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^e Jichi University   (Japan)

^f GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

autoantibodies; glomerulonephritis; moesin; myeloperoxidase; neutrophil

Indexed keywords

AUTOANTIBODY; CREATININE; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 7; MOESIN AUTOANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ANCA ASSOCIATED VASCULITIS; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY TITER; ANTIGEN BINDING; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MONOCYTE; NEUTROPHIL; PRIORITY JOURNAL;

AUTOANTIBODIES; GLOMERULONEPHRITIS; MOESIN; MYELOPEROXIDASE; NEUTROPHIL;

ADULT; AGED; AGED, 80 AND OVER; ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; AUTOANTIBODIES; CHEMOKINES; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKINS; MACROPHAGE INFLAMMATORY PROTEINS; MALE; MICROFILAMENT PROTEINS; MIDDLE AGED; PEROXIDASE;

EID: 84901780367     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gft469     Document Type: Article

References (44)

1. Falk RJ, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 1988; 318: 1651-1657
2. Kallenberg CG, Brouwer E, Weening JJ et al. Anti-neutrophil cytoplasmic antibodies: current diagnostic and pathophysiological potential. Kidney Int 1994; 46: 1-15 (Pubitemid 24210431)
3. Gross WL. Antineutrophil cytoplasmic autoantibody testing in vasculitides. Rheum Dis Clin North Am 1995; 21: 987-1011 (Pubitemid 26002534)
4. Hess C, Sadallah S, Schifferli JA. Induction of neutrophil responsiveness to myeloperoxidase antibodies by their exposure to supernatant of degranulated autologous neutrophils. Blood 2000; 96: 2822-2827
5. Harper L, Radford D, Plant T et al. Igg from myeloperoxidase- antineutrophil cytoplasmic antibody-positive patients stimulates greater activation of primed neutrophils than IgG from proteinase 3-antineutrophil cytosplasmic antibody-positive patients. Arthritis Rheum 2001; 44: 921-930 (Pubitemid 32319785)
6. Hoshino A, Nagao T, Nagi-Miura N et al. MPO-ANCA induces IL-17 production by activated neutrophils in vitro via classical complement pathway-dependent manner. J Autoimmun 2008; 31: 79-89 (Pubitemid 351685761)
7. Charles LA, Caldas ML, Falk RJ et al. Antibodies against granule proteins activate neutrophils in vitro. J Leukoc Biol 1991; 50: 539-546
8. LittleMA, Smyth CL, Yadav R et al. Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo. Blood 2005; 106: 2050-2058 (Pubitemid 41291719)
9. Fujimoto S, Uezono S, Hisanaga S et al. Incidence of ANCA-associated primary renal vasculitis in the Miyazaki Prefecture: the first populationbased, retrospective, epidemiologic survey in Japan. Clin J Am Soc Nephrol 2006; 1: 1016-1022
10. Schonermarck U, Lamprecht P, Csernok E et al. Prevalence and spectrum of rheumatic diseases associated with proteinase 3-antineutrophil cytoplasmic antibodies (ANCA) and myeloperoxidase-ANCA. Rheumatology (Oxford) 2001; 40: 178-184
11. Arimura Y, Minoshima S, Kamiya Y et al. Serum myeloperoxidase and serum cytokines in anti-myeloperoxidase antibody-associated glomerulonephritis. Clin Nephrol 1993; 40: 256-264 (Pubitemid 23333356)
12. Feldmann M, Pusey CD. Is there a role for TNF-alpha in anti-neutrophil cytoplasmic antibody-associated vasculitis? Lessons from other chronic inflammatory diseases. J Am Soc Nephrol 2006; 17: 1243-1252 (Pubitemid 43673404)
13. Volger OL, Fledderus JO, Kisters N et al. Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis. Am J Pathol 2007; 171: 326-337 (Pubitemid 47339249)
14. Falk RJ, Terrell RS, Charles LA et al. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci USA 1990; 87: 4115-4119 (Pubitemid 20217992)
15. Little MA, Bhangal G, Smyth CL et al. Therapeutic effect of anti-TNF-alpha antibodies in an experimental model of anti-neutrophil cytoplasm antibody- associated systemic vasculitis. J Am Soc Nephrol 2006; 17: 160-169
16. Iwata Y, Furuichi K, Kaneko S et al. The role of cytokine in the lupus nephritis. J Biomed Biotechnol 2011; 2011: 594809
17. Brown Z, Gerritsen ME, Carley WWet al. Chemokine gene expression and secretion by cytokine-activated human microvascular endothelial cells. Differential regulation of monocyte chemoattractant protein-1 and interleukin- 8 in response to interferon-gamma. Am J Pathol 1994; 145: 913-921
18. Saadoun D, Bieche I, Maisonobe T et al. Involvement of chemokines and type 1 cytokines in the pathogenesis of hepatitis C virus-associated mixed cryoglobulinemia vasculitis neuropathy. Arthritis Rheum 2005; 52: 2917-2925 (Pubitemid 41369123)
19. Xiao H, Heeringa P, Liu Z et al. The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies. Am J Pathol 2005; 167: 39-45 (Pubitemid 40884768)
20. Nagao T, Matsumura M, Mabuchi A et al. Up-regulation of adhesion molecule expression in glomerular endothelial cells by anti-myeloperoxidase antibody. Nephrol Dial Transplant 2007; 22: 77-87 (Pubitemid 46050331)
21. Neumann I, Birck R, Newman M et al. SCG/Kinjoh mice: a model of ANCA-associated crescentic glomerulonephritis with immune deposits. Kidney Int 2003; 64: 140-148 (Pubitemid 36714166)
22. Nagao T, Suzuki K, Utsunomiya K et al. Direct activation of glomerular endothelial cells by anti-moesin activity of anti-myeloperoxidase antibody. Nephrol Dial Transplant 2011; 26: 2752-2760
23. Suzuki K. Neutrophil functions of patients with vasculitis related to myeloperoxidase- specific anti-neutrophil antibody. Int J Hematol 2001; 74: 134-143 (Pubitemid 33760062)
24. Neisch AL, Fehon RG. Ezrin, Radixin and Moesin: key regulators of membrane- cortex interactions and signaling. Curr Opin Cell Biol 2011; 23: 377-382
25. Bretscher A, Edwards K, Fehon RG. ERM Proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol 2002; 3: 586-599
26. Niggli V, Rossy J. Ezrin/radixin/moesin: versatile controllers of signaling molecules and of the cortical cytoskeleton. Int J Biochem Cell Biol 2008; 40: 344-349 (Pubitemid 351241219)
27. Keresztes M, Lajtos Z, Fischer J et al. Moesin becomes linked to the plasma membrane in attached neutrophil granulocytes. Biochem Biophys Res Commun 1998; 252: 723-727 (Pubitemid 28556843)
28. Espinoza JL, Takamatsu H, Lu X et al. Anti-moesin antibodies derived from patients with aplastic anemia stimulate monocytic cells to secrete TNF-alpha through an ERK1/2-dependent pathway. Int Immunol 2009; 21: 913-923
29. Takamatsu H, Feng X, Chuhjo T et al. Specific antibodies to moesin, a membrane-cytoskeleton linker protein, are frequently detected in patients with acquired aplastic anemia. Blood 2007; 109: 2514-2520 (Pubitemid 46425896)
30. Roberts A, Chan Y, Wiedmann M. Definition of genetically distinct attenuation mechanisms in naturally virulence-attenuated Listeria monocytogenes by comparative cell culture and molecular characterization. Appl Environ Microbiol 2005; 71: 3900-3910 (Pubitemid 40980561)
31. Stratta P, Messuerotti A, Canavese C et al. The role of metals in autoimmune vasculitis: epidemiological and pathogenic study. Sci Total Environ 2001; 270: 179-190 (Pubitemid 32753120)
32. Nozu T, Kondo M, Suzuki K et al. A comparison of the clinical features of ANCA-positive and ANCA-negative idiopathic pulmonary fibrosis patients. Respiration 2009; 77: 407-415
33. Kurata A, Nishimura Y, Yamato T et al. Systemic granulomatous necrotizing vasculitis in a MPO-ANCA-positive patient. Pathol Int 2004; 54: 636-640 (Pubitemid 39149856)
34. Choi HK, Merkel PA, Walker AM et al. Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis: prevalence among patients with high titers of antimyeloperoxidase antibodies. Arthritis Rheum 2000; 43: 405-413 (Pubitemid 30395751)
35. Takamatsu H, Espinoza JL, Lu X et al. Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma. J Immunol 2009; 182: 703-710
36. Matsuyama A, Sakai N, Hiraoka H et al. Cell surface-expressed moesinlike HDL/apoA-I binding protein promotes cholesterol efflux from human macrophages. J Lipid Res 2006; 47: 78-86 (Pubitemid 43107451)
37. Popa ER, Franssen CF, Limburg PC et al. In vitro cytokine production and proliferation of T cells from patients with anti-proteinase 3- and antimyeloperoxidase- associated vasculitis, in response to proteinase 3 and myeloperoxidase. Arthritis Rheum 2002; 46: 1894-1904 (Pubitemid 34774522)
38. Papi M, Didona B, De Pita O et al. Livedo vasculopathy vs small vessel cutaneous vasculitis: cytokine and platelet P-selectin studies. Arch Dermatol 1998; 134: 447-452 (Pubitemid 28207626)
39. Ohlsson S, Bakoush O, Tencer J et al. Monocyte chemoattractant protein 1 is a prognostic marker in ANCA-associated small vessel vasculitis. Mediators Inflamm 2009; 2009: 584916
40. Kurita N, Mise N, Fujii A et al. Myeloperoxidase-antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis with rheumatoid arthritis: a comparison of patients without rheumatoid arthritis. Clin Exp Nephrol 2010; 14: 325-332
41. Kawakami M, Oka Y, Tsuboi A et al. Clinical and immunologic responses to very low-dose vaccination with WT1 peptide (5 microg/body) in a patient with chronic myelomonocytic leukemia. Int J Hematol 2007; 85: 426-429 (Pubitemid 47457454)
42. Wikman A, Lundahl J, Jacobson SH. Sustained monocyte activation in clinical remission of systemic vasculitis. Inflammation 2008; 31: 384-390
43. Huugen D, Xiao H, van Esch A et al. Aggravation of anti-myeloperoxidase antibody-induced glomerulonephritis by bacterial lipopolysaccharide: role of tumor necrosis factor-alpha. Am J Pathol 2005; 167: 47-58 (Pubitemid 40884769)
44. Bai Y, Liu R, Huang D et al. CCL2 Recruitment of IL-6-producing CD11b + monocytes to the draining lymph nodes during the initiation of Th17- dependent B cell-mediated autoimmunity. Eur J Immunol 2008; 38: 1877-1888