Methylmercury toxicity: Amelioration by selenium and water-soluble chelators as N-acetyl cysteine and dithiothreitol

Cell Biochemistry and Function

Volumn 32, Issue 4, 2014, Pages 351-360

  Joshi, Deepmala ^a,b   Mittal, Deepak Kumar ^a   Shukla, Sangeeta ^a   Srivastav, Ajai Kumar ^b   Srivastav, Sunil Kumar ^b  

^a JIWAJI UNIVERSITY   (India)

^b D D U GORAKHPUR UNIVERSITY   (India)

Author keywords

Chelation; Dithiothreitol; Histology; Methylmercury toxicity; N acetyl cysteine; Selenium

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AMINOPYRINE N DEMETHYLASE; ANTIDOTE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 2E1; DITHIOTHREITOL; GLUTATHIONE; LACTATE DEHYDROGENASE; METHYLMERCURY; SELENIUM; UNSPECIFIC MONOOXYGENASE; CHELATING AGENT; METHYLMERCURY DERIVATIVE; POLLUTANT; SELENIUM DERIVATIVE; WATER;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN TOXICITY; DRUG EFFICACY; ENZYME RELEASE; LIPID PEROXIDATION; LIVER TOXICITY; MALE; MERCURIALISM; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN; DRUG EFFECTS; KIDNEY; LIVER; METABOLISM; OXIDATIVE STRESS; POLLUTANT; SOLUBILITY; SPRAGUE DAWLEY RAT; TOXICITY;

RATTUS;

ACETYLCYSTEINE; ANIMALS; BRAIN; CHELATING AGENTS; DITHIOTHREITOL; ENVIRONMENTAL POLLUTANTS; KIDNEY; LIVER; MALE; METHYLMERCURY COMPOUNDS; OXIDATIVE STRESS; RATS, SPRAGUE-DAWLEY; SELENIUM COMPOUNDS; SOLUBILITY; WATER;

EID: 84901766015     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.3023     Document Type: Article

References (44)

1. Clarkson TW, Magos L. The toxicology of mercury and its chemical compounds. Crit Rev Toxicol 2006; 36: 609-662.
2. Kouimtzis TH. Environmental Chemistry. Ziti Publishers: Thessalonica, Greece (in greek), 1994.
3. Rooney JP. The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury. Toxicology 2007; 234: 145-156.
4. Singh V, Joshi D, Shrivastava S, Shukla S. Effect of monothiol along with antioxidant against mercury-induced oxidative stress in rat. Indian J Exp Biol 2007; 45: 1037-044.
5. Sanchez DJ, Gomez M, Llobet JM, Domingo JL. Effects of meso-2, 3-dimercaptosuccinic acid (DMSA) on methyl mercury-induced teratogenesis in mice. Ecotoxicol Environ Saf 1993; 26: 33-39.
6. Patricia I, Paul K, Lam C, et al. 2004. Exposure to lead and mercury in children and chelation therapy. Council of the Hong Kong College of Paediatricians Ltd.
7. Lund ME, Banner W, Jr, Clarkson TW, Berlin M. Treatment of acute methylmercury ingestion by hemodialysis with N-acetylcysteine (Mucomyst) infusion and 2, 3-dimercaptopropane sulfonate. J Toxicol Clin Toxicol 1984; 22: 31-39.
8. Juresa D, Blanusa M, Kostial K. Simultaneous administration of sodium selenite and mercuric chloride decreases efficacy of DMSA and DMPS in mercury elimination in rats. Toxico Lett 2005; 155: 97-102.
9. Robak J, Marcinkiewicz E. Scavenging of reactive oxygen species as the mechanism of drug action. Pol J Pharmacol 1995; 47: 89-98.
10. Gordon GF. EDTA and chelation therapy: history and mechanisms of action-an update. Clin Pract Alt Med 2001; 2: 36-45.
11. De Flora S, Izzotti A, D'Agostini F, Balansky RM. Mechanisms of N-acetyl cysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end points. Carcinogenesis 2001; 22: 999-1013.
12. Aremu DA, Madejczyk MS, Ballatori N. N-acetyl cysteine as a potential antidote and biomonitoring agent of methylmercury exposure. Environ Health Perspect 2008; 116: 26-31.
13. Ballatori N, Lieberman MW, Wang W. N-acetyl cysteine as an antidote in methylmercury poisoning. Environ Health Perspect 1998; 106: 267-271.
14. Hultberg B, Andersson A, Isaksson A. Lipoic acid increases glutathione production and enhances the effect of mercury in human cell lines. Toxicology 2002; 175: 103-110.
15. Agarwal R, Behari JR. Effect of selenium pretreatment in chronic mercury intoxication in rats. Bull Environ Contam Toxicol 2007; 79: 306-310.
16. Goyer R, Klaassen CD, Waalkes MP. Metal Toxicology. Academic Press: Oxford, UK, 1995; 35-37.
17. Hoffman DJ, Heinz GH. Effects of methylmercury and selenium on glutathione metabolism and oxidative stress in mallard ducks. Environl Toxicol Chem 1998; 17: 161-166.
18. Santos APM, Mateus ML, Carvalho CML, Batoreu MCC. Biomarkers of exposure and effect as indicators of the interference of selenomethionine on methylmercury toxicity. Toxicol Lett 2007; 169: 121-28.
19. Ralston NVC, Ralston CR, Blackwell JL, III, Raymond LJ. Dietary and tissue selenium in relation to methylmercury toxicity. Neurotoxicology 2008; 29: 802-811.
20. RTECS (Registry of Toxic Effects of Chemical Substances). U.S. Dept. of Health and Human Services, Wahington DC. 1985-1986.
21. Giradi E, Elias M. Effect of different glutathione levels on renal mercury deposition and excretion in the rat. Toxicology 1993; 81: 57-67.
22. Barnes J, McDowell E, McNeil J, Flamenbaum W, Trump B. Studies on the pathophysiology of acute renal failure IV. Protective effect of dithiothreitol following administration of mercuric chloride in rat. Virch Arch B Cell Pathol 1980; 32: 201-232.
23. Johri S, Srivastava S, Sharma P, Shukla S. Analysis of time dependent recovery from beryllium toxicity following chelation therapy and antioxidant supplementation. Indian J Exp Biol 2004; 42: 798-802.
24. Joshi D, Mittal D, Shrivastava S, Shukla S. Protective role of thiol chelators against dimethylmercury induced toxicity in male rats. Bull Environ Contam Toxicol 2010a; 84: 613-617.
25. Joshi D, Mittal D, Nirala SK, Bhadauria M, Shrivastava S, Shukla S. Role of micronutrients against dimethylmercury intoxication in male rats. Environ Toxicol Pharmacol 2010b; 29: 97-103.
26. Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am J Clin Pathol 1957; 28: 56-63.
27. Fiske CH, Subbarow Y. Colorimetric determination of phosphatase. J Biol Chem 1925; 66: 375-400.
28. Wroblewski F, LaDue JS. Colorimetric method for LDH. In Microanalysis in medical biochemistry, 4th edn, Wootton IDP (ed.). J and A Churchill Ltd: Gloucester Place, London, 1955; 15-118.
29. Schenkman JB, Cinti DL. Preparation of microsomes with calcium. Methods Enzymol 1978; 52: 83-89.
30. Kato R, Gillette JR. Effect of starvation on NADPH-dependent enzymes in liver microsomes of male and female rats. J Pharmacol Exp Ther 1965; 150: 279-284.
31. Cochin J, Axelrod J. Biochemical pharmacological changes in the rats following chronic administration of morphine. J Pharmacol Exp Ther 1959; 125: 105-110.
32. Sharma SK, KrishnaMurti CR. Production of lipidperoxides of brain. J Neurochem 1968; 15: 147-149.
33. Brehe JE, Burch HB. Enzymatic assay for glutathione. Anal Biochem 1976; 74: 189-197.
34. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with Folin's phenol reagent. J Biol Chem 1951; 193: 265-275.
35. Vandenberghe J. Hepatotoxicology: mechanisms of liver toxicity and methodological aspects. In Toxicology, Principles and Applications, Niesink RJM, Vries JD, Hollinger MA, (eds.). chapter 23. CRC Press Inc.: Boca Raton, FL, 1996; 702-723.
36. Flora GJS, Mathur R, Sandhu N, Dua KK. Time dependent preventive effects of simultaneous administration of selenium or zinc during mercury exposure in rats. Indian J Pharmacol 1994; 26: 209-212.
37. Kavitha AV, Jagadeesan G. Influence of Tribulus terrestris (Linn.) against mercuric chloride induced hepatic damage in mice Mus musculus (Linn.). Trop Biomed 2004; 21: 1-7.
38. Shukla S, Singh V, Joshi D. Modulation of toxic effects of organic mercury by different antioxidants. Toxicol Int 2007; 14: 67-71.
39. Lu SC. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J 1999; 13: 1169-1183.
40. Zhao JQ, Wen YF, Bhadauria M, et al. Protective effects of propolis on inorganic mercury induced oxidative stress in mice. Indian J Exp Biol 2009; 47: 264-269.
41. Rana SVS, Allen T, Singh R. Inevitable glutathione, then and now. Indian J Exp Biol 2002; 40: 706-716.
42. Singh RP, Khanna R, Kaw JL, Khanna SK, Das M. Comparative effect of benzanthrone and 3-bromobenzanthrone on hepatic xenobiotics metabolism and antioxidative defense system in guinea pigs. Arch Toxicol 2003; 77: 94-99.
43. Zhao P, Kalhorn TF, Slattery JT. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver. Hepatology 2002; 36: 326-335.
44. Agarwal R, Kumar R, Behari JR. Mercury and lead content in fish species from the river gomti, lucknow, India, as biomarkers of contamination. Bull Environ Contam Toxicol 2007; 78: 108-112.