Autologous fat grafting: In search of the optimal technique

Surgical Innovation

Volumn 21, Issue 3, 2014, Pages 327-336

  Kakagia, Despoina ^a,b   Pallua, Norbert ^b  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

autologous fat grafting; breast surgery; evidence based medicine surgery; liposuction; maxillofacial surgery; pediatric surgery; tissue engineering

Indexed keywords

ADIPOSE TISSUE; AUTOLOGOUS FAT GRAFTING; AUTOTRANSPLANTATION; CELL VIABILITY; DONOR SITE; GRAFT FAILURE; GRAFT SURVIVAL; HUMAN; MEDLINE; PATIENT SAFETY; PROCESSING; REIMPLANTATION; RELIABILITY; REVIEW; SURGEON; SURGICAL TECHNIQUE; TISSUE GRAFT; BREAST RECONSTRUCTION; EVIDENCE BASED MEDICINE; FEMALE; LIPECTOMY; PLASTIC SURGERY; PROCEDURES; TISSUE ENGINEERING; TRANSPLANTATION;

ADIPOSE TISSUE; EVIDENCE-BASED MEDICINE; FEMALE; HUMANS; LIPECTOMY; MAMMAPLASTY; RECONSTRUCTIVE SURGICAL PROCEDURES; TISSUE ENGINEERING; TRANSPLANTATION, AUTOLOGOUS;

EID: 84901764925     PISSN: 15533506     EISSN: 15533514     Source Type: Journal    
DOI: 10.1177/1553350613518846     Document Type: Review

References (87)

1. Billings E, May JW. Historical review and present status of free fat graft autotransplantation in plastic and reconstructive surgery. Plast Reconstr Surg. 1989 ; 83: 368-381
2. Tabit CJ, Slack GC, Fan K, et al. Fat grafting versus adipose-derived stem cell therapy: distinguishing indications, techniques, and outcomes. Aesthetic Plast Surg. 2012 ; 36: 704-713
3. Neuber F. Fetttransplantation. Zentrabl Chir. 1893 ; 22: 66
4. Illouz YG, de Villers YT Body Sculpturing by Lipoplasty. New York, NY: Churchill Livingstone ; 1989: 120-126.
5. Pu LL. Towards more rationalized approach to autologous fat grafting. J Plast Reconstr Aesthet Surg. 2012 ; 65: 413-419
6. Coleman SR. Structural fat grafts: the ideal filler?. Clin Plast Surg. 2001 ; 28: 111-119
7. Grimaldi M, Gentile P, Labardi L, et al. Lipostructure technique in Romberg syndrome. J Craniofac Surg. 2008 ; 19: 1089-1091
8. Coleman SR. Facial recontouring with lipostructure. Clin Plast Surg. 1997 ; 24: 347-367
9. Fontdevila J, Serra-Renom JM, Raigosa M, et al. Assessing the long-term viability of facial fat grafts: an objective measure using computed tomography. Aesthet Surg J. 2008 ; 28: 380-386
10. Tzikas TL. Lipografting: autologous fat grafting for total facial rejuvenation. Facial Plast Surg. 2004 ; 20: 135-143
11. Chasan PE, Rahban SR. Presacral donor site for lip augmentation. Aesthetic Plast Surg. 2000 ; 24: 31-33
12. Trepsat F. Periorbital rejuvenation combining fat grafting and blepharoplasties. Aesthetic Plast Surg. 2003 ; 27: 243-253
13. Kim SM, Kim YS, Hong JW, et al. An analysis of the experiences of 62 patients with moderate complications after full-face fat injection for augmentation. Plast Reconstr Surg. 2012 ; 129: 1359-1368
14. Aboudib JHC, Cardoso de Castro C, Gradel J. Hand rejuvenescence by fat filling. Ann Plast Surg. 1992 ; 28: 559-564
15. Klinger M, Marazzi M, Vigo D, et al. Fat injection for cases of severe burn outcomes: a new perspective of scar remodeling and reduction. Aesthetic Plast Surg. 2008 ; 32: 465-469
16. Rigotti G, Marchi A, Galie M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg. 2007 ; 119: 1409-1424
17. Saint-Cyr M, Rojas K, Colohan S, et al. The role of fat grafting in reconstructive and cosmetic breast surgery: a review of the literature. J Reconstr Microsurg. 2012 ; 28: 99-110
18. Claro F, Figueiredo JC, Zampar AG, et al. Applicability and safety of autologous fat for reconstruction of the breast. Br J Surg. 2012 ; 99: 768-780
19. Delay E, Sinna R, Chekaroua K, et al. Lipomodeling of Poland's syndrome: a new treatment of the thoracic deformity. Aesthetic Plast Surg. 2010 ; 34: 218-225
20. Del Vecchio D. Breast reconstruction for breast asymmetry using recipient site preexpansion and autologous fat grafting: a case report. Ann Plast Surg. 2009 ; 62: 523-527
21. Cronin T, Gerow F Transactions of the Third International Congress of Plastic Surgery. Amsterdam, Netherlands: Excerpta Medica Foundation ; 1964: 41-49.
22. Mojallal A, Veber M, Shipkov C, et al. Analysis of a series of autologous fat tissue transfer for lower limb atrophies. Ann Plast Surg. 2008 ; 61: 537-543
23. Duskova M, Kristen M. Augmentation by autologous adipose tissue in cleft lip and nose: final esthetic touches in clefts. Part I. J Craniofac Surg. 2004 ; 15: 478-481
24. Bardot J, Salazard B, Casanova D, et al. Velopharyngeal sequels in labial-Alveolar-velopalatine clefts: pharyngoplasty by pharynx lipostructure. Rev Stomatol Chir Maxillofac. 2007 ; 108: 352-356
25. Kim SS, Kawamoto HK, Kohan E, et al. Reconstruction of the irradiated orbit with autogenous fat grafting for improved ocular implant. Plast Reconstr Surg. 2010 ; 126: 213-220
26. Vaienti L, Gazzola R, Villani F, et al. Perineural fat grafting in the treatment of painful neuromas. Tech Hand Up Extrem Surg. 2012 ; 16: 52-55
27. Li TS, Choong MY, Wu CI, et al. Autologous fat graft to restore nail bed contour following resection of a subungual glomus. J Hand Surg Am. 2011 ; 36: 726-728
28. Wolford LM, Morales-Ryan CA, Morales PG, et al. Autologous fat grafts placed around temporomandibular joint total joint prostheses to prevent heterotopic bone formation. Proc (Bayl Univ Med Cent). 2008 ; 21: 248-254
29. Mehta GU, Oldfield EH. Prevention of intraoperative cerebrospinal fluid leaks by lumbar cerebrospinal fluid drainage during surgery for pituitary microadenomas. J Neurosurg. 2012 ; 116: 1299-1303
30. Sanna M, Taibah A, Russo A, et al. Perioperative complications in acoustic neuroma (vestibular schwannoma) surgery. Otol Neurotol. 2004 ; 25: 379-386
31. Keerl R, Weber R, Kahle G, et al. Magnetic resonance imaging after frontal sinus surgery with fat obliteration. J Laryngol Otol. 1995 ; 109: 1115-1119
32. Zhang HY, Xu W, Lü ZH, et al. Vocal fold augmentation by injection of autologous fascia and fat. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 ; 46: 269-274
33. Lolli P, Malleo G, Rigotti G. Treatment of chronic anal fissures and associated stenosis by autologous adipose tissue transplant: a pilot study. Dis Colon Rectum. 2010 ; 53: 460-466
34. Lacreuse I, Moog R, Kadoch V, et al. Autologous adipocyte graft in endoscopic treatment of vesico-renal reflux in children: a preliminary study. Pediatr Rep. 2009 ; 1: e7
35. Hudson DA, Lambert EV, Block CE. Site selection for fat autotransplantation: some observations. Aesthetic Plast Surg. 1990 ; 14: 195-197
36. Rohrich RJ, Sorokin ES, Brown SA. In search of improved fat transfer viability: a quantitative analysis of the role of centrifugation and harvest site. Plast Reconstr Surg. 2004 ; 113: 391-395
37. Padoin AV, Braga-Silva J, Martins P, et al. Sources of processed lipoaspirate cells: influence of donor site on cell concentration. Plast Reconstr Surg. 2008 ; 122: 614-618
38. Gir P, Brown SA, Oni G, et al. Fat grafting: evidence-based review on autologous fat harvesting, processing, reinjection, and storage. Plast Reconstr Surg. 2012 ; 130: 249-258
39. Ullmann Y, Shoshani O, Fodor A, et al. Searching for the favorable donor site for fat injection: in vivo study using the nude mice model. Dermatol Surg. 2005 ; 31: 1304-1307
40. Kaufman MR, Bradley JP, Dickinson B, et al. Autologous fat transfer consensus survey: trends in techniques for harvest, preparation, and application, and perception of short- and long-term results. Plast Reconstr Surg. 2007 ; 119: 323-331
41. Pu LL, Coleman SR, Cui X, et al. Autologous fat grafts harvested and refined by the Coleman technique: a comparative study. Plast Reconstr Surg. 2008 ; 122: 932-937
42. Fagrell D, Enestrom S, Berggren A, et al. Fat cylinder transplantation: an experimental comparative study of three different kinds of fat transplants. Plast Reconstr Surg. 1996 ; 98: 90
43. Qin W, Xu Y, Liu X, Xu S. Experimental and primary clinical research of core fat graft. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012 ; 26: 576-582
44. Pu LL, Cui X, Fink BF, et al. The viability of fatty tissues within adipose aspirates after conventional liposuction: a comprehensive study. Ann Plast Surg. 2005 ; 54: 288-292
45. Erdim M, Tezel E, Numanoglu A, et al. The effects of the size of liposuction cannula on adipocyte survival and the optimum temperature for fat graft storage: an experimental study. J Plast Reconstr Aesthet Surg. 2009 ; 62: 1210-1214
46. Rubin A, Hoefflin SM. Fat purification: survival of the fittest. Plast Reconstr Surg. 2002 ; 109: 1463-1464
47. Nordstrom REA. "Spaghetti" fat grafting: a new technique. Plast Reconstr Surg. 1997 ; 99: 917-918
48. Carpaneda CA, Ribeiro MT. Study of the histologic alterations and viability of the adipose graft in humans. Aesthetic Plast Surg. 1993 ; 17: 43-47
49. Karacalar A, Ozcan M. Liposuction of the kneecap area under tourniquet: a superdry procedure. Aesthetic Plast Surg. 1998 ; 22: 408-411
50. Nguyen PS, Desouches C, Gay AM, et al. Development of micro-injection as an innovative autologous fat graft technique: the use of adipose tissue as dermal filler. J Plast Reconstr Aesthet Surg. 2012 ; 65: 1692-1699
51. Alharbi Z, Opländer C, Almakadi S, Fritz A, Vogt M, Pallua N. Conventional vs. micro-fat harvesting: how fat harvesting technique affects tissue-engineering approaches using adipose tissue-derived stem/stromal cells. Plast Reconstr Aesthet Surg. 2013 ; 66: 1271-1278
52. Rennekampff HO, Reimers K, Gabka CJ, et al. Current perspective and limitations of autologous fat transplantation. Handchir Mikrochir Plast Chir. 2010 ; 42: 137-142
53. Fournier PF, Otteni FM. Lipodissection in body sculpturing: the dry procedure. Plast Reconstr Surg. 1983 ; 72: 598-609
54. Klein JA. Tumescent technique for local anesthesia improves safety in large-volume liposuction. Plast Reconstr Surg. 1993 ; 92: 1085-1100
55. Agostini T, Lazzeri D, Pini A, et al. Wet and dry techniques for structural fat graft harvesting: histomorphometric and cell viability assessments of lipoaspirated samples. Plast Reconstr Surg. 2012 ; 130: 331e - 339e
56. Keck M, Zeyda M, Gollinger K, et al. Local anesthetics have a major impact on viability of preadipocytes and their differentiation into adipocytes. Plast Reconstr Surg. 2010 ; 126: 1500-1505
57. Livaoǧlu M, Buruk CK, Uraloglu M, et al. Effects of lidocaine plus epinephrine and prilocaine on autologous fat graft survival. J Craniofac Surg. 2012 ; 23: 1015-1018
58. Shoshani O, Berger J, Fodor L, et al. The effect of lidocaine and adrenaline on the viability of injected adipose tissue-An experimental study in nude mice. J Drugs Dermatol. 2005 ; 4: 311-316
59. Sasaki GH. Water-Assisted liposuction for body contouring and lipoharvesting: safety and efficacy in 41 consecutive patients. Aesthet Surg J. 2011 ; 31: 76-88
60. Peltoniemi HH, Salmi A, Miettinen S, et al. Stem cell enrichment does not warrant a higher graft survival in lipofilling of the breast: a prospective comparative study. Plast Reconstr Aesthet Surg. 2013 ; 66: 1494-1503
61. Condé-Green A, de Amorim NF, Pitanguy I. Influence of decantation, washing and centrifugation on adipocyte and mesenchymal stem cell content of aspirated adipose tissue: a comparative study. J Plast Reconstr Aesthet Surg. 2010 ; 63: 1375-1381
62. Rose JG, Lucarelli MJ, Lemke BN, et al. Histologic comparison of autologous fat processing methods. Ophthal Plast Reconstr Surg. 2006 ; 22: 195-200
63. Ueberreiter K, von Finckenstein JG, Cromme F, et al. BEAULI™: a new and easy method for large-volume fat grafts. Handchir Mikrochir Plast Chir. 2010 ; 42: 379-385
64. Cytori Therapeutics. Cytori-sponsored clinical trials. http://www.cytori.com/Innovations/ClinicalTrials.aspx. Accessed December 18, 2013.
65. Minn KW, Min KH, Chang H, et al. Effects of fat preparation methods on the viabilities of autologous fat grafts. Aesthetic Plast Surg. 2010 ; 34: 626-631
66. Ramon Y, Shoshani O, Peled IJ, et al. Enhancing the take of injected adipose tissue by a simple method for concentrating fat cells. Plast Reconstr Surg. 2005 ; 115: 197-201
67. Botti G, Pascali M, Botti C, et al. A clinical trial in facial fat grafting: filtered and washed versus centrifuged fat. Plast Reconstr Surg. 2011 ; 127: 2464-2473
68. Ferraro GA, De Francesco F, Tirino V, et al. Effects of a new centrifugation method on adipose cell viability for autologous fat grafting. Aesthetic Plast Surg. 2011 ; 35: 341-348
69. Crawford JL, Hubbard BA, Colbert SH, et al. Fine tuning lipoaspirate viability for fat grafting. Plast Reconstr Surg. 2010 ; 126: 1342-1348
70. Pulsfort AK, Wolter TP, Pallua N. The effect of centrifugal forces on viability of adipocytes in centrifuged lipoaspirates. Ann Plast Surg. 2011 ; 66: 292-295
71. Peer LA. Loss of weight and volume in human fat grafts: with postulation of a "cell survival theory.". Plast Reconstr Surg. 1950 ; 5: 217-230
72. Del Vecchio D, Rohrich RJ. A classification of clinical fat grafting: different problems, different solutions. Plast Reconstr Surg. 2012 ; 130: 511-522
73. Smith CJ, Khouri RK, Baker TJ. Initial experience with the Brava nonsurgical system of breast enhancement. Plast Reconstr Surg. 2002 ; 110: 1593-1595
74. Khouri RK, Baker TJ. Initial experience with the BRAVA nonsurgical system of breast enhancement. Plast Reconstr Surg. 2002 ; 110: 1593-1595
75. Butterwick KJ, Lack EA. Facial volume restoration with the fat autograft muscle injection technique. Dermatol.Surg. 2003 ; 29: 1019-1026
76. De Ugarte D, Ashjian PH, Elbarbary A, et al. Future of fat as raw material for tissue regeneration. Ann Plast Surg. 2003 ; 50: 215-219
77. Butterwick KJ, Nootheti PK, Hsu JW, et al. Autologous fat transfer: an in-depth look at varying concepts and techniques. Facial Plast Surg Clin North Am. 2007 ; 15: 99-111
78. US patent 5461030 (Lidenbaum).. 1995 ; 24 :
79. Yuksel E, Weinfeld A, Cleek R, et al. Increased free fat-graft survival with the long-term, local delivery of insulin, insulin-like growth factor-I, and basic fibroblast growth factor by PLGA/ PEG microspheres. Plast Reconstr Surg. 2000 ; 105: 1712-1720
80. Palma PC, Vidal B, Riccetto CL, et al. Effect of purified collagen on lipograft survival: experimental basis for periurethral lipoinjections. J Endourol. 2003 ; 17: 255-259
81. Piasecki JH, Gutowski KA, Moreno KM, et al. Purified viable fat suspended in matrigel improves volume longevity. Aesthet Surg J. 28: 24-32
82. Shoshani O, Shupak A, Ullmann Y, et al. The effect of hyperbaric oxygenation on the viability of human fat injected into nude mice. Plast Reconstr Surg. 2000 ; 6: 1390-1396
83. Baek RM, Park SO, Jeong EC, et al. The effect of botulinum toxin A on fat graft survival. Aesthetic Plast Surg. 2012 ; 36: 680-686
84. Kamakura T, Ito K. Autologous cell-enriched fat grafting for breast augmentation. Aesthetic Plast Surg. 2011 ; 35: 1022-1030
85. Yoshimura K, Sato K, Aoi N, et al. Cell-Assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells. Dermatol Surg. 2008 ; 34: 1178-1185
86. Marino G, Moraci M, Armenia E, et al. Therapy with autologous adipose-derived regenerative cells for the care of chronic ulcer of lower limbs in patients with peripheral arterial disease. J Surg Res. 2013 ; 185: 36-44
87. Wu AY, Morrow DM. Autologous fat transfer with in-situ mediation (AIM): a novel and compliant method of adult mesenchymal stem cell therapy. J Transl Med. 2013 ; 11: 136