Neuron-specific alterations in signal transduction pathways associated with Alzheimer's Disease

Journal of Alzheimer's Disease

Volumn 40, Issue 1, 2014, Pages 135-142

  Gerschütz, Anne ^a   Heinsen, Helmut ^a   Grünblatt, Edna ^b   Wagner, Anne Kristin ^a   Bartl, Jasmin ^b   Meissner, Christoph ^c   Fallgatter, Andreas J ^d   Al Sarraj, Safa ^e   Troakes, Claire ^e   Ferrer, Isidro ^f   Arzberger, Thomas ^g   Deckert, Jürgen ^a   Riederer, Peter ^a   Fischer, Matthias ^a   Tatschner, Thomas ^a   Monoranu, Camelia Maria ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^g UNIVERSITY OF MUNICH   (Germany)

Author keywords

Alzheimer's disease; MAPK1; neurodegeneration; PRKCB; selective vulnerability; signal transduction pathway

Indexed keywords

MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE C BETA;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GRANULE CELL; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA2 REGION; HUMAN; HUMAN TISSUE; LASER MICRODISSECTION; MALE; NERVE CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; TRIGEMINAL NUCLEUS;

ALZHEIMER'S DISEASE; MAPK1; NEURODEGENERATION; PRKCB; SELECTIVE VULNERABILITY; SIGNAL TRANSDUCTION PATHWAY;

AGE FACTORS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; FEMALE; GENE EXPRESSION REGULATION; HUMANS; LASER CAPTURE MICRODISSECTION; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 1; NEURONS; PROTEIN KINASE C BETA; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84901756515     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-131280     Document Type: Article

References (34)

1. Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82, 239-259.
2. Mizutani T, Shimada H (1991) Quantitative study of neu-rofibrillary tangles in subdivisions of the hippocampus. CA2 as a special area in normal aging and senile dementia of the Alzheimer type. Acta Pathol Jpn 41, 597-603.
3. Davies DC, Horwood N, Isaacs SL, Mann DM (1992) The effect of age and Alzheimer's disease on pyramidal neuron density in the individual fields of the hippocampal formation. Acta Neuropathol 83, 510-517.
4. Braak H, Braak E, Bohl J, Lang W (1989) Alzheimer's disease: Amyloid plaques in the cerebellum. J Neurol Sci 93, 277-287.
5. Larner AJ (1997) The cerebellum in Alzheimer's disease. Dement Geriatr Cogn Disord 8, 203-209.
6. Mavroudis IA, Fotiou DF, Adipepe LF, Manani MG, Njau SD, Psaroulis D, Costa VG, Baloyannis SJ (2010) Morphological changesof the human purkinje cells and deposition ofneuritic plaques and neurofibrillary tangles on the cerebellar cortex of Alzheimer's disease. Am J Alzheimers Dis Other Demen 25, 585-591.
7. Grudzien A, Shaw P, Weintraub S, Bigio E, Mash DC, Mesu-lam MM (2007) Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease. Neurobiol Aging 28, 327-335.
8. Braak H, Del Tredici K (2011) The pathological process underlying Alzheimer's disease in individuals under thirty. Acta Neuropathol 121, 171-181.
9. Grinberg LT, Rueb U, Heinsen H (2011) Brainstem: Neglected locus in neurodegenerative diseases. Front Neurol 2, 42.
10. Attems J, Thomas A, Jellinger K (2012) Correlations between cortical and subcortical tau pathology.Neuropathol Appl Neu-robiol 38, 582-590.
11. Fallgatter AJ, Ehlis AC, Ringel TM, Herrmann MJ (2005) Age effect on far field potentials from the brain stem after transcutaneous vagus nerve stimulation. Int J Psychophysiol 56, 37-43.
12. Fallgatter AJ, Neuhauser B, Herrmann MJ, Ehlis AC, Wagener A, Scheuerpflug P, Reiners K, Riederer P (2003) Far field potentials from the brain stem after transcuta-neous vagus nerve stimulation. J Neural Transm 110, 1437-1443.
13. Nomura S, Mizuno N (1983) Central distribution of efferent and afferent components of the cervical branches of the vagus nerve. A HRP studyin the cat. Anat Embryol (Berl) 166, 1-18.
14. Vogt C, Vogt O (1928) Die Grundlagen und die Teildisziplinen der mikroskopischen Anatomie des Zentralnervensystems. In Das Zentralnervensystem, Möllendorff W, ed. Verlag Von Julius Springer, Berlin, pp. 448-477.
15. Hyman BT, Elvhage TE, Reiter J (1994) Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease. Am J Pathol 144, 565-572.
16. Ferrer I, Blanco R, Carmona M, Puig B (2001) Phospho-rylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. J Neural Transm 108, 1397-1415.
17. Pei JJ, Braak H, An WL, Winblad B, Cowburn RF, Iqbal K, Grundke-Iqbal I (2002) Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease. Brain Res Mol Brain Res 109, 45-55.
18. Pascale A, Amadio M, Govoni S, Battaini F (2007) The aging brain, akey target for the future: The protein kinase C involvement. Pharmacol Res 55, 560-569.
19. Weeraratna AT, Kalehua A, Deleon I, Bertak D, Maher G, Wade MS, Lustig A, Becker KG, Wood 3rd W, Walker DG, Beach TG, Taub DD (2007) Alterationsinimmunological and neurological gene expression patterns in Alzheimer's disease tissues. Exp Cell Res 313, 450-461.
20. Saitoh T, Horsburgh K, Masliah E (1993) Hyperactivation of signal transduction systems in Alzheimer's disease. Ann N Y Acad Sci 695, 34-41.
21. Grundemann J, Schlaudraff F, Haeckel O, Liss B (2008) Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease. Nucleic Acids Res 36, e38.
22. Ruijter JM, Ramakers C, Hoogaars WM, Karlen Y, Bakker O, van den Hoff MJ, Moorman AF (2009) Amplification efficiency: Linking baseline and bias in the analysis of quantitative PCR data. Nucleic Acids Res 37, e45.
23. Zhu X, Castellani RJ, Takeda A, Nunomura A, Atwood CS, Perry G, Smith MA (2001) Differential activation of neuronal ERK, JNK/SAPK and p38inAlzheimer disease: The 'two hit' hypothesis. Mech Ageing Dev 123, 39-46.
24. Drewes G, Lichtenberg-Kraag B, Doring F, Mandelkow EM, Biernat J, Goris J, Doree M, Mandelkow E (1992) Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state. EMBO J 11, 2131-2138.
25. Illenberger S, Zheng-Fischhofer Q, Preuss U, Stamer K, Baumann K, Trinczek B, Biernat J, Godemann R, Mandelkow EM, Mandelkow E (1998) The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: Implications for Alzheimer's disease. Mol Biol Cell 9, 1495-1512.
26. Reynolds CH, Betts JC, Blackstock WP, Nebreda AR, Anderton BH (2000) Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: Differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta. J Neurochem 74, 1587-1595.
27. Cole G, Dobkins KR, Hansen LA, Terry RD, Saitoh T (1988) Decreased levelsofprotein kinaseCinAlzheimer brain.Brain Res 452, 165-174.
28. Masliah E, Cole G, Shimohama S, Hansen L, DeTeresa R, Terry RD, Saitoh T (1990) Differential involvement of protein kinase C isozymes in Alzheimer's disease. J Neurosci 10, 2113-2124.
29. Alldred MJ, Duff KE, Ginsberg SD (2012) Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction. Neurobiol Dis 45, 751-762.
30. Stephan H (1975) Allocortex. In Handbuch der mikroskopischen Anatomie des Menschen, vol 4, part 9, Bargmann W, ed. Springer, Berlin, pp. 1-998.
31. Ginsberg SD, Alldred MJ, Che S (2012) Gene expression levels assessed by CA1 pyramidal neuron and regional hip-pocampal dissections in Alzheimer's disease. Neurobiol Dis 45, 99-107.
32. Yan SF, Harja E, Andrassy M, Fujita T, Schmidt AM (2006) Protein kinase C beta/early growth response-1 pathway: A key player in ischemia, atherosclerosis, and restenosis. J Am Coll Cardiol 48(9 Suppl 1), A47-A55.
33. Kawakami T, Kawakami Y, Kitaura J (2002) Protein kinase C beta (PKC beta): Normal functions and diseases. J Biochem 132, 677-682.
34. Rüb U, Del Tredici K, Schultz C, Thal DR, Braak E, Braak H (2001) The autonomic higher order processing nuclei of the lower brain stem are among the early targets of the Alzheimer's disease-related cytoskeletal pathology. Acta Neuropathol 101, 555-564.