Implications of the E-selectin S128R mutation for drug discovery

Glycobiology

Volumn 24, Issue 7, 2014, Pages 592-601

  Preston, Roland C ^a   Rabbani, Said ^a   Binder, Florian P C ^a   Moes, Suzette ^b   Magnani, John L ^c   Ernst, Beat ^a  

^a Institute of Molecular Pharmacy   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c GlycoMimetics   (United States)

Author keywords

E selectin; S128R; selectin antagonists; single nucleotide polymorphism

Indexed keywords

CARBOHYDRATE; E SELECTIN ANTAGONIST; FETUIN; HEPARIN; PROTEIN INHIBITOR; SIALYL LEWIS X ANTIGEN; TETRASACCHARIDE; UNCLASSIFIED DRUG; 5-ACETYLNEURAMINYL-(2-3)-GALACTOSYL-(1-4)-(FUCOPYRANOSYL-(1-3))-N-ACETYLGLUCOSAMINE; AMINOSUGAR; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; LIGAND; OLIGOSACCHARIDE; PROTEIN BINDING; SIALYL-N-ACETYLLACTOSAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNE DISEASE; CARDIOVASCULAR DISEASE; CELL SUSPENSION; CELL VIABILITY; CHO CELL LINE; CONTROLLED STUDY; DNA SEQUENCE; FAST PROTEIN LIQUID CHROMATOGRAPHY; GENE MUTATION; HL 60 CELL LINE; K562 CELL LINE; LEUKOCYTE; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN GLYCOSYLATION; SHEAR STRESS; TANDEM MASS SPECTROMETRY; ANIMAL; CRICETULUS; DRUG DEVELOPMENT; GENETICS; HAMSTER; HUMAN; METABOLISM; MICROARRAY ANALYSIS; MISSENSE MUTATION; PROCEDURES; TUMOR CELL LINE;

AMINO SUGARS; ANIMALS; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DISCOVERY; E-SELECTIN; FETUINS; HEPARIN; HUMANS; LIGANDS; MICROARRAY ANALYSIS; MUTATION, MISSENSE; OLIGOSACCHARIDES; PROTEIN BINDING;

EID: 84901755029     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwu026     Document Type: Article

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