Does vitamin E improve the outcomes of pediatric nonalcoholic fatty liver disease? A systematic review and meta-analysis

Saudi Journal of Gastroenterology

Volumn 20, Issue 3, 2014, Pages 143-153

  Sarkhy, Ahmed ^a,d   Al Hussaini, Abdulrahman ^b   Nobili, Valerio ^c  

^a KING KHALID UNIVERSITY HOSPITAL   (Saudi Arabia)

^b KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

^c BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

antioxidants; steatohepatitis; steatosis; Tocopherol

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; ASPARTATE AMINOTRANSFERASE;

HISTOLOGY; HUMAN; META ANALYSIS; NONALCOHOLIC FATTY LIVER; OUTCOME ASSESSMENT; PUBLISHING; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SENSITIVITY ANALYSIS; SIDE EFFECT; SYSTEMATIC REVIEW; TREATMENT DURATION; ADOLESCENT; AGE; CHILD; DIET SUPPLEMENTATION; FEMALE; MALE; NON-ALCOHOLIC FATTY LIVER DISEASE; PRESCHOOL CHILD; PROGNOSIS; RISK ASSESSMENT; SAUDI ARABIA; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

ADOLESCENT; AGE FACTORS; CHILD; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; NON-ALCOHOLIC FATTY LIVER DISEASE; PROGNOSIS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK ASSESSMENT; SAUDI ARABIA; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; VITAMIN E;

EID: 84901720847     PISSN: 13193767     EISSN: 19984049     Source Type: Journal    
DOI: 10.4103/1319-3767.132983     Document Type: Review

References (28)

1. Della Corte C, Alisi A, Saccari A, De Vito R, Vania A, Nobili V. Nonalcoholic fatty liver in children and adolescents: An overview. J Adolesc Health 2012;51:305-12
2. Mencin AA, Lavine JE. Nonalcoholic fatty liver disease in children. Curr Opin Clin Nutr Metab Care 2011;14:151-7
3. Alkhouri N, Dixon LJ, Feldstein AE. Lipotoxicity in nonalcoholic fatty liver disease: Not all lipids are created equal. Expert Rev Gastroenterol Hepatol 2009;3:445-51
4. Patton HM, Lavine JE, Van Natta ML, Schwimmer JB, Kleiner D, Molleston J, et al. Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis. Gastroenterology 2008;135: 1961-71.e2
5. Promrat K, Kleiner DE, Niemeier HM, Jackvony E, Kearns M, Wands JR, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 2010;51:121-9
6. Nobili V, Marcellini M, Devito R, Ciampalini P, Piemonte F, Comparcola D, et al. NAFLD in children: A prospective clinical-pathological study and effect of lifestyle advice. Hepatology 2006;44:458-65. (Pubitemid 44214885)
7. Adinolfi LE, Restivo L. Does vitamin E cure nonalcoholic steatohepatitis? Expert Rev Gastroenterol Hepatol 2011;5:147-50
8. Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010;362:1675-85
9. Lavine JE, Schwimmer JB, Van Natta ML, Molleston JP, Murray KF, Rosenthal P, et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: The TONIC randomized controlled trial. JAMA 2011;305:1659-68
10. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. www.cochrane-handbook.org
11. DerSimonian R, Laird N. Meta-Analysis in clinical trials. Control Clin Trials 1986;7:177-88
12. Vajro P, Mandato C, Franzese A, Ciccimarra E, Lucariello S, Savoia M, et al. Vitamin E treatment in pediatric obesity-related liver disease: A randomized study. J Pediatr Gastroenterol Nutr 2004;38:48-55. (Pubitemid 39274467)
13. Nobili V, Manco M, Devito R, Ciampalini P, Piemonte F, Marcellini M. Effect of vitamin E on aminotransferase levels and insulin resistance in children with non-Alcoholic fatty liver disease. Aliment Pharmacol Ther 2006;24:1553-61. (Pubitemid 44915203)
14. Nobili V, Manco M, Devito R, Di Ciommo V, Comparcola D, Sartorelli MR, et al. Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: A randomized, controlled trial. Hepatology 2008;48:119-28. (Pubitemid 351975537)
15. Wang CL, Liang L, Fu JF, Zou CC, Hong F, Xue JZ, et al. Effect of lifestyle intervention on non-Alcoholic fatty liver disease in Chinese obese children. World J Gastroenterol 2008;14:1598-602. (Pubitemid 351460179)
16. Wu F. Clinical study on prevention efficacy of Jianpi Huatan Fang in treating non-Alcoholic fatty liver disease in children. Zhongguo Zhong Yao Za Zhi 2012;37:2465-8
17. Schürks M, Glynn RJ, Rist PM, Tzourio C, Kurth T. Effects of vitamin E on stroke subtypes: Meta-Analysis of randomised controlled trials. BMJ. 2010;341:c5702
18. Sutton AJ, Duval SJ, Tweedie RL, Abrams KR, Jones DR. Empirical assessment of effect of publication bias on meta-Analyses. BMJ 2000;320:1574-7
19. Manco M, Alisi A, Nobili V. Risk of severe liver disease in NAFLD with normal ALT levels: A pediatric report. Hepatology 2008;48:2087-8
20. Wieckowska A, McCullough AJ, Feldstein AE. Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: Present and future. Hepatology 2007;46:582-9. (Pubitemid 47344794)
21. Lirussi F, Azzalini L, Orando S, Orlando R, Angelico F. Antioxidant supplements for non-Alcoholic fatty liver disease and/or steatohepatitis. Cochrane Database Syst Rev 2007;1:CD004996
22. Socha P, Horvath A, Vajro P, Dziechciarz P, Dhawan A, Szajewska H. Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: A systematic review. J Pediatr Gastroenterol Nutr 2009;48:587-96
23. Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, Benson JT, Enders FB, Angulo P. The natural history of non-Alcoholic fatty liver disease in children: A follow-up study for up to 20 years. Gut 2009;58:1538-44
24. Schwimmer JB, Behling C, Newbury R, Deutsch R, Nievergelt C, Schork NJ, et al. Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology 2005;42:641-9. (Pubitemid 41233657)
25. Sanyal AJ, Mofrad PS, Contos MJ, Sargeant C, Luketic VA, Sterling RK, et al. A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 2004;2:1107-15. (Pubitemid 40037642)
26. Harrison SA, Torgerson S, Hayashi P, Ward J, Schenker S. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2003;98:2485-90. (Pubitemid 37448761)
27. Dufour JF, Oneta CM, Gonvers JJ, Bihl F, Cerny A, Cereda JM, et al. Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin e in nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 2006;4:1537-43. (Pubitemid 44880031)
28. Foster T, Budoff MJ, Saab S, Ahmadi N, Gordon C, Guerci AD. Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: The St Francis Heart Study randomized clinical trial. Am J Gastroenterol 2011;106:71-7.