Physiologically based pharmacokinetic- pharmacodynamic modeling to the rescue: Understanding how resuscitation from local anesthetic overdose with lipid emulsions works

Anesthesiology

Volumn 120, Issue 4, 2014, Pages 795-796

  Tucker, Geoffrey T ^a  

^a CERTARA UK LIMITED   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; LIPID EMULSION; CARDIOTONIC AGENT;

CARDIOTOXICITY; DRUG BLOOD LEVEL; EDITORIAL; HEART OUTPUT; HEART RATE; HEMODILUTION; HUMAN; LOCAL ANESTHESIA; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REGIONAL ANESTHESIA; RESUSCITATION; ANIMAL; CHEMICALLY INDUCED DISORDER; HEART ARREST; MALE; METHODOLOGY; NOTE;

ANIMALS; BUPIVACAINE; CARDIOTONIC AGENTS; FAT EMULSIONS, INTRAVENOUS; HEART ARREST; MALE; RESUSCITATION;

EID: 84901708579     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000000143     Document Type: Editorial

References (7)

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5. Tucker GT, Mather LE: Pharmacokinetics of local anaesthetic agents. Br J Anaesth 1975; 47:213-24.
6. Burm AG, de Boer AG, van Kleef JW, Vermeulen NP, de Leede LG, Spierdijk J, Breimer DD: Pharmacokinetics of lidocaine and bupivacaine and stable isotope labelled analogues: A study in healthy volunteers. Biopharm Drug Dispos 1988; 9:85-95.
7. Fettiplace MR, Akpa BS, Ripper R, Zider B, Lang J, Rubinstein I, Weinberg G: Rescuscitation with lipid emulsion: Dose- dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect. Anesthesiology 2014; 120:915-25.