Application of a telomerase-based circulating tumor cell (CTC) assay in bladder cancer patients receiving postoperative radiation therapy: A case study

Cancer Biology and Therapy

Volumn 15, Issue 6, 2014, Pages 683-687

  Ju, Melody ^a   Kao, Gary D ^a   Steinmetz, David ^a   Chandrasekaran, Sanjay ^a   Keefe, Stephen M ^a   Guzzo, Thomas J ^b   Christodouleas, John P ^a   Hahn, Stephen M ^a   Dorsey, Jay F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Bladder cancer; Circulating tumor cell; CTC; Ctc assay; Radiation therapy; Telomerase

Indexed keywords

BCG VACCINE; CISPLATIN; GEMCITABINE; TELOMERASE; TUMOR MARKER;

ABDOMINAL MASS; ADULT; AGED; ARTICLE; BLADDER CANCER; BLADDER CARCINOMA; BLOOD SAMPLING; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER GROWTH; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CANCER SURGERY; CARCINOGENESIS; CASE REPORT; CELL ASSAY; CIRCULATING TUMOR CELL; CIRCULATING TUMOR CELL ASSAY; COMPUTER ASSISTED TOMOGRAPHY; CYSTECTOMY; CYSTOSCOPY; DISEASE COURSE; DISTANT FAILURE FREE SURVIVAL; FEMALE; FOLLOW UP; HEMATURIA; HUMAN; IMAGING; LOCAL FAILURE FREE SURVIVAL; LYMPH NODE DISSECTION; MALE; MEDICAL HISTORY; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; MUSCLE INVASIVE BLADDER CANCER; MUSCLE INVASIVE BLADDER CARCINOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; POSTOPERATIVE CARE; PRIMARY TUMOR; RADIATION DOSE; RADIATION RESPONSE; REPEAT PROCEDURE; RETROSPECTIVE STUDY; TRANSITIONAL CELL CARCINOMA; TRANSURETHRAL RESECTION; TUMOR INVASION; ADJUVANT THERAPY; CARCINOMA, TRANSITIONAL CELL; ENZYME ASSAY; ENZYMOLOGY; FATALITY; METABOLISM; TREATMENT OUTCOME; TUMOR EMBOLISM; URINARY BLADDER NEOPLASMS;

AGED; CARCINOMA, TRANSITIONAL CELL; ENZYME ASSAYS; FATAL OUTCOME; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASTIC CELLS, CIRCULATING; RADIOTHERAPY, ADJUVANT; TELOMERASE; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS;

EID: 84901699416     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.28412     Document Type: Article

References (24)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009; 59:225-49; PMID:19474385; http://dx.doi.org/10.3322/ caac.20006
2. Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, Reuben JM, Doyle GV, Allard WJ, Terstappen LW, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 2004; 351:781-91; PMID:15317891; http://dx.doi.org/10.1056/NEJMoa040766
3. Cohen SJ, Punt CJ, Iannotti N, Saidman BH, Sabbath KD, Gabrail NY, Picus J, Morse M, Mitchell E, Miller MC, et al. Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26:3213-21; PMID:18591556; http://dx.doi.org/10.1200/JCO.2007.15.8923
4. Danila DC, Heller G, Gignac GA, Gonzalez-Espinoza R, Anand A, Tanaka E, Lilja H, Schwartz L, Larson S, Fleisher M, et al. Circulating tumor cell number and prognosis in progressive castration-resistant prostate cancer. Clin Cancer Res 2007; 13:7053-8; PMID:18056182; http://dx.doi.org/10.1158/1078-0432.CCR-07- 1506
5. de Bono JS, Scher HI, Montgomery RB, Parker C, Miller MC, Tissing H, Doyle GV, Terstappen LW, Pienta KJ, Raghavan D. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin Cancer Res 2008; 14:6302-9; PMID:18829513; http://dx.doi.org/10. 1158/1078-0432.CCR-08-0872
6. Flaig TW, Wilson S, van Bokhoven A, Varella-Garcia M, Wolfe P, Maroni P, Genova EE, Morales D, Lucia MS. Detection of circulating tumor cells in metastatic and clinically localized urothelial carcinoma. Urology 2011; 78:863-7; PMID:21813167; http://dx.doi.org/10.1016/j.urology.2011.05.045
7. Gallagher DJ, Milowsky MI, Ishill N, Trout A, Boyle MG, Riches J, Fleisher M, Bajorin DF. Detection of circulating tumor cells in patients with urothelial cancer. Ann Oncol 2009; 20:305-8; PMID:18836088; http://dx.doi.org/ 10.1093/annonc/mdn627
8. Gazzaniga P, Gradilone A, de Berardinis E, Busetto GM, Raimondi C, Gandini O, Nicolazzo C, Petracca A, Vincenzi B, Farcomeni A, et al. Prognostic value of circulating tumor cells in nonmuscle invasive bladder cancer: a CellSearch analysis. Ann Oncol 2012; 23:2352-6; PMID:22351740; http://dx.doi.org/10.1093/annonc/mdr619
9. Guzzo TJ, McNeil BK, Bivalacqua TJ, Elliott DJ, Sokoll LJ, Schoenberg MP. The presence of circulating tumor cells does not predict extravesical disease in bladder cancer patients prior to radical cystectomy. Urol Oncol 2012; 30:44-8; PMID:20005748; http://dx.doi.org/10.1016/j.urolonc.2009.10.008
10. Naoe M, Ogawa Y, Morita J, Omori K, Takeshita K, Shichijyo T, Okumura T, Igarashi A, Yanaihara A, Iwamoto S, et al. Detection of circulating urothelial cancer cells in the blood using the CellSearch System. Cancer 2007; 109:1439-45; PMID:17326057; http://dx.doi.org/10.1002/cncr.22543
11. Small AC, Gong Y, Oh WK, Hall SJ, van Rijn CJ, Galsky MD. The emerging role of circulating tumor cell detection in genitourinary cancer. J Urol 2012; 188:21-6; PMID:22578722; http://dx.doi.org/10.1016/j.juro.2012.02.2558
12. Gradilone A, Petracca A, Nicolazzo C, Gianni W, Cortesi E, Naso G, Vincenzi B, Cristini C, De Berardinis E, Di Silverio F, et al. Prognostic significance of survivin-expressing circulating tumour cells in T1G3 bladder cancer. BJU Int 2010; 106:710-5; PMID:20128783; http://dx.doi.org/10.1111/j. 1464-410X.2009.09130.x
13. Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997; 33:787-91; PMID:9282118; http://dx.doi.org/10.1016/S0959- 8049(97)00062-2
14. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266:2011-5; PMID:7605428; http://dx.doi.org/10.1126/science.7605428
15. Kojima T, Hashimoto Y, Watanabe Y, Kagawa S, Uno F, Kuroda S, Tazawa H, Kyo S, Mizuguchi H, Urata Y, et al. A simple biological imaging system for detecting viable human circulating tumor cells. J Clin Invest 2009; 119:3172-81; PMID:19729837; http://dx.doi.org/10.1172/JCI38609
16. Maida Y, Kyo S, Sakaguchi J, Mizumoto Y, Hashimoto M, Mori N, Ikoma T, Nakamura M, Takakura M, Urata Y, et al. Diagnostic potential and limitation of imaging cancer cells in cytological samples using telomerase-specific replicative adenovirus. Int J Oncol 2009; 34:1549-56; PMID:19424572
17. Nezos A, Pissimisis N, Lembessis P, Sourla A, Dimopoulos P, Dimopoulos T, Tzelepis K, Koutsilieris M. Detection of circulating tumor cells in bladder cancer patients. Cancer Treat Rev 2009; 35:272-9; PMID:19103472; http://dx.doi.org/10.1016/j.ctrv.2008.11.003
18. Soria JC, Morat L, Durdux C, Housset M, Cortez A, Blaise R, Sabatier L. The molecular detection of circulating tumor cells in bladder cancer using telomerase activity. J Urol 2002; 167:352-6; PMID:11743355; http://dx.doi.org/ 10.1016/S0022-5347(05)65467-5
19. Msaouel P, Koutsilieris M. Diagnostic value of circulating tumor cell detection in bladder and urothelial cancer: systematic review and meta-analysis. BMC Cancer 2011; 11:336; PMID:21816094; http://dx.doi.org/10.1186/1471-2407-11- 336
20. Rink M, Chun FK, Minner S, Friedrich M, Mauermann O, Heinzer H, Huland H, Fisch M, Pantel K, Riethdorf S. Detection of circulating tumour cells in peripheral blood of patients with advanced non-metastatic bladder cancer. BJU Int 2011; 107:1668-75; PMID:20735381; http://dx.doi.org/10.1111/j.1464-410X. 2010.09562.x
21. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
22. Liu Z, Li Q, Li K, Chen L, Li W, Hou M, Liu T, Yang J, Lindvall C, Björkholm M, et al. Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells. Oncogene 2013; 32:4203-13; PMID:23045275; http://dx.doi.org/10.1038/onc.2012.441
23. Kim SJ, Masago A, Tamaki Y, Akazawa K, Tsukamoto F, Sato J, Ozawa T, Tsujino Y, Noguchi S. A novel approach using telomerase-specific replication-selective adenovirus for detection of circulating tumor cells in breast cancer patients. Breast Cancer Res Treat 2011; 128:765-73; PMID:21630023; http://dx.doi.org/10.1007/s10549-011-1603-2
24. Karl A, Tritschler S, Hofmann S, Stief CG, Schindlbeck C. Perioperative search for circulating tumor cells in patients undergoing radical cystectomy for bladder cancer. Eur J Med Res 2009; 14:487-90; PMID:19948444; http://dx.doi.org/10.1186/2047-783X-14-11-487