TNFα and IFNγ but Not Perforin Are Critical for CD8 T Cell-Mediated Protection against Pulmonary Yersinia pestis Infection

PLoS Pathogens

Volumn 10, Issue 5, 2014, Pages

  Szaba, Frank M ^a   Kummer, Lawrence W ^a   Duso, Debra K ^a   Koroleva, Ekaterina P ^a   Tumanov, Alexei V ^a   Cooper, Andrea M ^a   Bliska, James B ^b   Smiley, Stephen T ^a   Lin, Jr Shiuan ^a  

^a TRUDEAU INSTITUTE   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; PERFORIN, MOUSE; PORE FORMING CYTOTOXIC PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; BACTERIAL PNEUMONIA; C57BL MOUSE; CD8+ T LYMPHOCYTE; CELL CULTURE; CELLULAR IMMUNITY; COMPLICATION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MOUSE; PHYSIOLOGY; PLAGUE; YERSINIA PESTIS;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; IMMUNITY, CELLULAR; INTERFERON-GAMMA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLAGUE; PNEUMONIA, BACTERIAL; PORE FORMING CYTOTOXIC PROTEINS; TUMOR NECROSIS FACTOR-ALPHA; YERSINIA PESTIS;

EID: 84901680640     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004142     Document Type: Article

References (26)

1. Perry RD, Fetherston JD, (1997) Yersinia pestis-etiologic agent of plague. Clin Microbiol Rev 10: 35-66.
2. Anevlavis S, Bouros D, (2010) Community acquired bacterial pneumonia. Expert Opin Pharmacother 11: 361-374.
3. Peleg AY, Hooper DC, (2010) Hospital-acquired infections due to gram-negative bacteria. N Engl J Med 362: 1804-1813.
4. Smiley ST, (2008) Current challenges in the development of vaccines for pneumonic plague. Expert Rev Vaccines 7: 209-221.
5. Bashaw J, Norris S, Weeks S, Trevino S, Adamovicz JJ, et al. (2007) Development of in vitro correlate assays of immunity to infection with Yersinia pestis. Clin Vaccine Immunol 14: 605-616.
6. Quenee LE, Ciletti NA, Elli D, Hermanas TM, Schneewind O, (2013) Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV10-2 or F1-V vaccines. Vaccine 29: 6572-6583.
7. Szaba FM, Kummer LW, Wilhelm LB, Lin JS, Parent MA, et al. (2009) D27-pLpxL, an avirulent strain of Yersinia pestis, primes T cells that protect against pneumonic plague. Infect Immun 77: 4295-4304.
8. Lin JS, Kummer LW, Szaba FM, Smiley ST, (2011) IL-17 contributes to cell-mediated defense against pulmonary Yersinia pestis infection. J Immunol 186: 1675-1684.
9. Kummer LW, Szaba FM, Parent MA, Adamovicz JJ, Hill J, et al. (2008) Antibodies and cytokines independently protect against pneumonic plague. Vaccine 26: 6901-6907.
10. Lin JS, Park S, Adamovicz JJ, Hill J, Bliska JB, et al. (2010) TNFalpha and IFNgamma contribute to F1/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plague. Vaccine 29: 357-362.
11. Harty JT, Tvinnereim AR, White DW, (2000) CD8+ T cell effector mechanisms in resistance to infection. Annu Rev Immunol 18: 275-308.
12. Wong P, Pamer EG, (2003) CD8 T cell responses to infectious pathogens. Annu Rev Immunol 21: 29-70.
13. Lin JS, Szaba FM, Kummer LW, Chromy BA, Smiley ST, (2011) Yersinia pestis YopE contains a dominant CD8 T cell epitope that confers protection in a mouse model of pneumonic plague. J Immunol 187: 897-904.
14. Zhang Y, Mena P, Romanov G, Lin JS, Smiley ST, et al. (2012) A protective epitope in type III effector YopE is a major CD8 T cell antigen during primary infection with Yersinia pseudotuberculosis. Infect Immun 80: 206-214.
15. Bergman MA, Loomis WP, Mecsas J, Starnbach MN, Isberg RR, (2009) CD8(+) T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells. PLoS Pathog 5: e1000573.
16. Wonderlich J, Shearer G, Livingstone A, Brooks A, (2006) Induction and measurement of cytotoxic T lymphocyte activity. Curr Protoc Immunol Chapter 3: Unit 3 11.
17. Kagi D, Ledermann B, Burki K, Seiler P, Odermatt B, et al. (1994) Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369: 31-37.
18. Grivennikov SI, Tumanov AV, Liepinsh DJ, Kruglov AA, Marakusha BI, et al. (2005) Distinct and nonredundant in vivo functions of TNF produced by T cells and macrophages/neutrophils: protective and deleterious effects. Immunity 22: 93-104.
19. Berg RE, Crossley E, Murray S, Forman J, (2003) Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen. J Exp Med 198: 1583-1593.
20. Lee-Lewis H, Anderson DM, (2010) Absence of inflammation and pneumonia during infection with nonpigmented Yersinia pestis reveals a new role for the pgm locus in pathogenesis. Infect Immun 78: 220-230.
21. Badovinac VP, Tvinnereim AR, Harty JT, (2000) Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science 290: 1354-1358.
22. Tsujimoto M, Yip YK, Vilcek J, (1986) Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor. J Immunol 136: 2441-2444.
23. Lukaszewski RA, Kenny DJ, Taylor R, Rees DG, Hartley MG, et al. (2005) Pathogenesis of Yersinia pestis infection in BALB/c mice: effects on host macrophages and neutrophils. Infect Immun 73: 7142-7150.
24. Narni-Mancinelli E, Campisi L, Bassand D, Cazareth J, Gounon P, et al. (2007) Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes. J Exp Med 204: 2075-2087.
25. Cook DN, Smithies O, Strieter RM, Frelinger JA, Serody JS, (1999) CD8+ T cells are a biologically relevant source of macrophage inflammatory protein-1 alpha in vivo. J Immunol 162: 5423-5428.
26. Parent MA, Berggren KN, Kummer LW, Wilhelm LB, Szaba FM, et al. (2005) Cell-mediated protection against pulmonary Yersinia pestis infection. Infect Immun 73: 7304-7310.