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Volumn 71, Issue 11, 2014, Pages 2149-2164

Combinatorial activity of Six1-2-4 genes in cephalic neural crest cells controls craniofacial and brain development

Author keywords

Electroporation; Head skeleton; Holoprosencephaly; Hoxa2; Neural crest; RNAi; Signaling

Indexed keywords

BONE MORPHOGENETIC PROTEIN; TRANSCRIPTION FACTOR SIX1;

EID: 84901673658     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-013-1477-z     Document Type: Article
Times cited : (39)

References (44)
  • 1
    • 0001119210 scopus 로고
    • Neural crest and the origin of vertebrates: A new head
    • 10.1126/science.220.4594.268 10.1126/science.220.4594.268
    • Gans C, Northcutt RG (1983) Neural crest and the origin of vertebrates: a new head. Science 20:268-274. doi: 10.1126/science.220.4594.268
    • (1983) Science , vol.20 , pp. 268-274
    • Gans, C.1    Northcutt, R.G.2
  • 2
    • 0000058778 scopus 로고    scopus 로고
    • Germ layers and the germ-layer theory revisited: Primary and secondary germ layers, neural crest as a fourth germ layer, homology, and demise of the germ-layer theory
    • 10.1007/978-1-4899-1751-5-5
    • Hall BK (1998) Germ layers and the germ-layer theory revisited: primary and secondary germ layers, neural crest as a fourth germ layer, homology, and demise of the germ-layer theory. Evol Biol 30:121-186
    • (1998) Evol Biol , vol.30 , pp. 121-186
    • Hall, B.K.1
  • 3
  • 4
    • 0004007167 scopus 로고    scopus 로고
    • 2 Cambridge University Press Cambridge 10.1017/CBO9780511897948
    • Le Douarin NM, Kalcheim C (1999) The neural crest, 2nd edn. Cambridge University Press, Cambridge
    • (1999) The Neural Crest
    • Le Douarin, N.M.1    Kalcheim, C.2
  • 5
    • 1842636932 scopus 로고    scopus 로고
    • Reciprocal relationships between Fgf8 and neural crest cells in development
    • 10.1073/pnas.0400869101 1:CAS:528:DC%2BD2cXjsFCju78%3D 387336 15041748 10.1073/pnas.0400869101
    • Creuzet S, Schuler B, Couly G, Le Douarin NM (2004) Reciprocal relationships between Fgf8 and neural crest cells in development. Proc Natl Acad Sci USA 101:4843-4847. doi: 10.1073/pnas.0400869101
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4843-4847
    • Creuzet, S.1    Schuler, B.2    Couly, G.3    Le Douarin, N.M.4
  • 6
    • 33749021645 scopus 로고    scopus 로고
    • The cephalic neural crest exerts a critical effect on forebrain and midbrain development
    • 10.1073/pnas.0605899103 10.1073/pnas.0605899103
    • Creuzet SE, Martinez S, Le Douarin NM (2006) The cephalic neural crest exerts a critical effect on forebrain and midbrain development. Proc Natl Acad Sci USA 103:1433-1438. doi: 10.1073/pnas.0605899103
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1433-1438
    • Creuzet, S.E.1    Martinez, S.2    Le Douarin, N.M.3
  • 7
    • 0030796030 scopus 로고    scopus 로고
    • Inductive interactions direct early regionalization of the mouse forebrain
    • 1:CAS:528:DyaK2sXkvFCjurc%3D 9226442 ISSN: 0950-1991
    • Shimamura K, Rubenstein JL (1997) Inductive interactions direct early regionalization of the mouse forebrain. Development 124:2709-2718 ISSN: 0950-1991
    • (1997) Development , vol.124 , pp. 2709-2718
    • Shimamura, K.1    Rubenstein, J.L.2
  • 8
    • 0032908043 scopus 로고    scopus 로고
    • FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression
    • 1:CAS:528:DyaK1MXisFWmsLs%3D 10021338 ISSN: 0950-1991
    • Martinez S, Crossley PH, Cobos I, Rubenstein JLR, Martin GR (1999) FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. Development 126:1189-1200 ISSN: 0950-1991
    • (1999) Development , vol.126 , pp. 1189-1200
    • Martinez, S.1    Crossley, P.H.2    Cobos, I.3    Rubenstein, J.L.R.4    Martin, G.R.5
  • 9
    • 0142138668 scopus 로고    scopus 로고
    • Neuroepithelial secondary organizers and cell fate specification in the developing brain
    • 10.1016/j.brainresrev.2003.08.002 14572913 10.1016/j.brainresrev.2003.08. 002
    • Echevarría D, Vieira C, Gimeno L, Martínez S (2003) Neuroepithelial secondary organizers and cell fate specification in the developing brain. Brain Res Rev 43:179-191. doi: 10.1016/j.brainresrev.2003.08. 002
    • (2003) Brain Res Rev , vol.43 , pp. 179-191
    • Echevarría, D.1    Vieira, C.2    Gimeno, L.3    Martínez, S.4
  • 10
    • 70349468056 scopus 로고    scopus 로고
    • Regulation of pre-otic brain development by the cephalic neural crest
    • 10.1073/pnas.0906072106 1:CAS:528:DC%2BD1MXhtFyjsLbI 2747194 19720987 10.1073/pnas.0906072106
    • Creuzet SE (2009) Regulation of pre-otic brain development by the cephalic neural crest. Proc Natl Acad Sci USA 106:15774-15779. doi: 10.1073/pnas.0906072106
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 15774-15779
    • Creuzet, S.E.1
  • 11
    • 0037156473 scopus 로고    scopus 로고
    • Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles
    • 10.1016/S0306-4522(01)00616-9 1:CAS:528:DC%2BD38XivVSns70%3D 11955708 10.1016/S0306-4522(01)00616-9
    • Ohkubo Y, Chiang C, Rubenstein JLR (2002) Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles. Neuroscience 111:1-17. doi: 10.1016/S0306-4522(01)00616-9
    • (2002) Neuroscience , vol.111 , pp. 1-17
    • Ohkubo, Y.1    Chiang, C.2    Rubenstein, J.L.R.3
  • 12
    • 0036744679 scopus 로고    scopus 로고
    • Negative effect of hox gene expression on the development of the neural crest-derived facial skeleton
    • 1:CAS:528:DC%2BD38XnvFGks7o%3D 12183382 ISSN: 0950-1991
    • Creuzet S, Couly G, Bennaceur S, Vincent C, Le Douarin NM (2002) Negative effect of hox gene expression on the development of the neural crest-derived facial skeleton. Development 129:4301-4313 ISSN: 0950-1991
    • (2002) Development , vol.129 , pp. 4301-4313
    • Creuzet, S.1    Couly, G.2    Bennaceur, S.3    Vincent, C.4    Le Douarin, N.M.5
  • 13
    • 14044279906 scopus 로고    scopus 로고
    • Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme
    • 10.1242/dev.01536 1:CAS:528:DC%2BD2MXhvVeltLc%3D 15634706 10.1242/dev.01536
    • Kutejova E, Engist B, Mallo M, Kanzler B, Bobola N (2005) Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme. Development 132:469-478. doi: 10.1242/dev.01536
    • (2005) Development , vol.132 , pp. 469-478
    • Kutejova, E.1    Engist, B.2    Mallo, M.3    Kanzler, B.4    Bobola, N.5
  • 15
    • 0029146034 scopus 로고
    • Plasticity of transposed rhombomeres: Hox gene induction is correlated with phenotypic modifications
    • 1:CAS:528:DyaK2MXotF2mt70%3D 7555700 ISSN: 0950-1991
    • Grapin-Botton A, Bonnin M-A, McNaughton LA, Krumlauf R, Le Douarin NM (1995) Plasticity of transposed rhombomeres: Hox gene induction is correlated with phenotypic modifications. Development 121:2707-2721 ISSN: 0950-1991
    • (1995) Development , vol.121 , pp. 2707-2721
    • Grapin-Botton, A.1    Bonnin, M.-A.2    McNaughton, L.A.3    Krumlauf, R.4    Le Douarin, N.M.5
  • 16
    • 0037227960 scopus 로고    scopus 로고
    • Screening for gene function in chicken embryo using RNAi and electroporation
    • 10.1038/nbt770 1:CAS:528:DC%2BD3sXhvV2h 10.1038/nbt770
    • Pekarik V, Bourikas D, Miglino N, Joset P, Stoekli E (2003) Screening for gene function in chicken embryo using RNAi and electroporation. Nat Biotech 21:93-96. doi: 10.1038/nbt770
    • (2003) Nat Biotech , vol.21 , pp. 93-96
    • Pekarik, V.1    Bourikas, D.2    Miglino, N.3    Joset, P.4    Stoekli, E.5
  • 17
    • 1642431836 scopus 로고    scopus 로고
    • RNAi in avian embryos
    • Cold Spring Harbor Laboratory, New York. ISBN 978-087969704-4
    • Stoeckli ET (2003) RNAi in avian embryos. In RNAi: a guide to gene silencing, 297-312. Cold Spring Harbor Laboratory, New York. ISBN 978-087969704-4
    • (2003) RNAi: A Guide to Gene Silencing , pp. 297-312
    • Stoeckli, E.T.1
  • 18
    • 33750455113 scopus 로고    scopus 로고
    • Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney
    • 10.1038/sj.emboj.7601381 1:CAS:528:DC%2BD28XhtFChsrzL 1630416 17036046 10.1038/sj.emboj.7601381
    • Self M, Lagutin OV, Bowling B, Hendrix J, Cai Y, Dressler GR, Oliver G (2006) Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J 25:5214-5228. doi: 10.1038/sj.emboj.7601381
    • (2006) EMBO J , vol.25 , pp. 5214-5228
    • Self, M.1    Lagutin, O.V.2    Bowling, B.3    Hendrix, J.4    Cai, Y.5    Dressler, G.R.6    Oliver, G.7
  • 20
    • 0029062934 scopus 로고
    • Expression of a delta homologue in prospective neurons in the chick
    • 10.1038/375787a0 1:CAS:528:DyaK2MXmvVymur0%3D 7596411 10.1038/375787a0
    • Henrique D, Adam J, Myat A, Chitnis A, Lewis J, Ish-Horowicz D (1995) Expression of a delta homologue in prospective neurons in the chick. Nature 375:787-790. doi: 10.1038/375787a0
    • (1995) Nature , vol.375 , pp. 787-790
    • Henrique, D.1    Adam, J.2    Myat, A.3    Chitnis, A.4    Lewis, J.5    Ish-Horowicz, D.6
  • 21
    • 0029960330 scopus 로고    scopus 로고
    • Midbrain development induced by FGF8 in the chick embryo
    • 10.1038/380066a0 1:CAS:528:DyaK28XhsFeisLc%3D 8598907 10.1038/380066a0
    • Crossley PH, Martinez S, Martin GR (1996) Midbrain development induced by FGF8 in the chick embryo. Nature 380:66-68. doi: 10.1038/380066a0
    • (1996) Nature , vol.380 , pp. 66-68
    • Crossley, P.H.1    Martinez, S.2    Martin, G.R.3
  • 22
    • 0027760995 scopus 로고
    • Sonic hedgehog mediates the polarizing activity of the ZPA
    • 10.1016/0092-8674(93)90626-2 10.1016/0092-8674(93)90626-2
    • Riddle RD, Johnson RL, Laufer E, Tabin CJ (1993) Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 25:1401-1416. doi: 10.1016/0092- 8674(93)90626-2
    • (1993) Cell , vol.25 , pp. 1401-1416
    • Riddle, R.D.1    Johnson, R.L.2    Laufer, E.3    Tabin, C.J.4
  • 23
    • 0028137737 scopus 로고
    • Bone morphogenetic proteins and a signaling pathway that controls patterning in the developing chick limb
    • 1:CAS:528:DyaK2cXmsFWmtLw%3D 8119128 ISSN: 0950-1991
    • Francis PH, Richardson MK, Brickell PM, Tickle C (1994) Bone morphogenetic proteins and a signaling pathway that controls patterning in the developing chick limb. Development 120:209-218 ISSN: 0950-1991
    • (1994) Development , vol.120 , pp. 209-218
    • Francis, P.H.1    Richardson, M.K.2    Brickell, P.M.3    Tickle, C.4
  • 24
    • 0031007343 scopus 로고    scopus 로고
    • Chick noggin is expressed in the organizer and neural plate during axial development, but offers no evidence of involvement in primary axis formation
    • 1:CAS:528:DyaK2sXksVGnsLw%3D 9184349 ISSN: 0214-6282
    • Connolly DJ, Patel K, Cooke J (1997) Chick noggin is expressed in the organizer and neural plate during axial development, but offers no evidence of involvement in primary axis formation. Int J Dev Biol 41:389-396 ISSN: 0214-6282
    • (1997) Int J Dev Biol , vol.41 , pp. 389-396
    • Connolly, D.J.1    Patel, K.2    Cooke, J.3
  • 25
    • 0037008880 scopus 로고    scopus 로고
    • Expression patterns of Wnt8b and Wnt7b in the chicken embryonic brain suggest a correlation with forebrain patterning centers and morphogenesis
    • 10.1016/S0306-4522(02)00171-9 1:CAS:528:DC%2BD38XlvVelt74%3D 12150789 10.1016/S0306-4522(02)00171-9
    • Garda AL, Puelles L, Rubenstein JLR (2002) Expression patterns of Wnt8b and Wnt7b in the chicken embryonic brain suggest a correlation with forebrain patterning centers and morphogenesis. Neuroscience 113:689-698. doi: 10.1016/S0306-4522(02)00171-9
    • (2002) Neuroscience , vol.113 , pp. 689-698
    • Garda, A.L.1    Puelles, L.2    Rubenstein, J.L.R.3
  • 26
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • 10.1093/nar/29.9.e45 1:STN:280:DC%2BD38nis12jtw%3D%3D 55695 11328886 10.1093/nar/29.9.e45
    • Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucl Acids Res 29:e45. doi: 10.1093/nar/29.9.e45
    • (2001) Nucl Acids Res , vol.29 , pp. 45
    • Pfaffl, M.W.1
  • 27
    • 0031941080 scopus 로고    scopus 로고
    • A novel mammalian Wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain
    • 10.1093/hmg/7.5.813 1:CAS:528:DyaK1cXjsVaku78%3D 9536085 10.1093/hmg/7.5.813
    • Lako M, Lindsay S, Bullen P, Wilson DI, Robson SC, Strachan T (1998) A novel mammalian Wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain. Hum Mol Gen 7:813-822. doi: 10.1093/hmg/7.5.813
    • (1998) Hum Mol Gen , vol.7 , pp. 813-822
    • Lako, M.1    Lindsay, S.2    Bullen, P.3    Wilson, D.I.4    Robson, S.C.5    Strachan, T.6
  • 28
    • 0346731134 scopus 로고    scopus 로고
    • Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle
    • 10.1093/hmg/7.5.813 1:CAS:528:DC%2BD2cXhs1Shug%3D%3D 10.1101/gad.1154103
    • Tzahor E, Kempf H, Mootoosamy RC, Poon AC, Abzhanov A, Tabin CJ, Dietrich S, Lassar AB (2003) Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle. Gen Dev 17:3087-3099. doi: 10.1093/hmg/7.5.813
    • (2003) Gen Dev , vol.17 , pp. 3087-3099
    • Tzahor, E.1    Kempf, H.2    Mootoosamy, R.C.3    Poon, A.C.4    Abzhanov, A.5    Tabin, C.J.6    Dietrich, S.7    Lassar, A.B.8
  • 29
    • 0032039482 scopus 로고    scopus 로고
    • The Xenopus dorsalizing factor gremlin identifies a novel family of secreted proteins that antagonize BMP activities
    • 10.1016/S1097-2765(00)80067-2 1:CAS:528:DyaK1cXivF2jsr4%3D 9660951 10.1016/S1097-2765(00)80067-2
    • Hsu DR, Economides AN, Wang X, Eimon PM, Harland RM (1998) The Xenopus dorsalizing factor gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell 1:673-683. doi: 10.1016/S1097-2765(00)80067- 2
    • (1998) Mol Cell , vol.1 , pp. 673-683
    • Hsu, D.R.1    Economides, A.N.2    Wang, X.3    Eimon, P.M.4    Harland, R.M.5
  • 30
    • 0034891352 scopus 로고    scopus 로고
    • Xenopus dan, a member of the dan gene family of BMP antagonists, is expressed in derivatives of the cranial and trunk neural crest
    • 10.1016/S0925-4773(01)00462-2 1:CAS:528:DC%2BD3MXmtFWhs7s%3D 11520677 10.1016/S0925-4773(01)00462-2
    • Eimon PM, Harland RM (2001) Xenopus dan, a member of the dan gene family of BMP antagonists, is expressed in derivatives of the cranial and trunk neural crest. Mech Dev 107:187-189. doi: 10.1016/S0925-4773(01)00462-2
    • (2001) Mech Dev , vol.107 , pp. 187-189
    • Eimon, P.M.1    Harland, R.M.2
  • 32
    • 44449095514 scopus 로고    scopus 로고
    • Six2 functions redundantly immediately downstream of Hoxa2
    • 10.1242/dev.017624 1:CAS:528:DC%2BD1cXmtFalu7c%3D 18321982 10.1242/dev.017624
    • Kutejova E, Engist B, Self M, Oliver G, Kirikenko P, Bobola N (2008) Six2 functions redundantly immediately downstream of Hoxa2. Development 135:1463-1470. doi: 10.1242/dev.017624
    • (2008) Development , vol.135 , pp. 1463-1470
    • Kutejova, E.1    Engist, B.2    Self, M.3    Oliver, G.4    Kirikenko, P.5    Bobola, N.6
  • 33
    • 77955618056 scopus 로고    scopus 로고
    • Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors
    • 10.1002/bdra.20695 1:CAS:528:DC%2BC3cXhtVKrsL%2FE 10.1002/bdra.20695
    • Fairbridge NA, Nicholas A, Dawe CE, Niri FH, Kooistra MK, King-Jones K, McDermid HE (2010) Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors. Birth Def Res A 88:619-625. doi: 10.1002/bdra.20695
    • (2010) Birth Def Res A , vol.88 , pp. 619-625
    • Fairbridge, N.A.1    Nicholas, A.2    Dawe, C.E.3    Niri, F.H.4    Kooistra, M.K.5    King-Jones, K.6    McDermid, H.E.7
  • 34
    • 60149107489 scopus 로고    scopus 로고
    • The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease
    • 10.1007/s00018-008-8335-4 1:CAS:528:DC%2BD1MXhvVOisrc%3D 2716997 18989625 10.1007/s00018-008-8335-4
    • Kumar JP (2009) The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease. Cell Mol Life Sci 66:565-583. doi: 10.1007/s00018-008-8335-4
    • (2009) Cell Mol Life Sci , vol.66 , pp. 565-583
    • Kumar, J.P.1
  • 35
    • 70449518282 scopus 로고    scopus 로고
    • Activation of Six1 target genes is required for sensory placode formation
    • 10.1016/j.ydbio.2009.09.025 1:CAS:528:DC%2BD1MXhsVWmu7vL 19781543 10.1016/j.ydbio.2009.09.025
    • Christophorou NA, Bailey AP, Hanson S, Streit A (2009) Activation of Six1 target genes is required for sensory placode formation. Dev Biol 336:327-336. doi: 10.1016/j.ydbio.2009.09.025
    • (2009) Dev Biol , vol.336 , pp. 327-336
    • Christophorou, N.A.1    Bailey, A.P.2    Hanson, S.3    Streit, A.4
  • 36
    • 81255177726 scopus 로고    scopus 로고
    • Development of gustatory papilla in the absence of Six1 and Six4
    • 10.1111/j.1469-7580.2011.01435.x 3237879 21978088 10.1111/j.1469-7580. 2011.01435.x
    • Suzuki Y, Keiko I, Kawakami K (2011) Development of gustatory papilla in the absence of Six1 and Six4. J Anat 219:710-721. doi: 10.1111/j.1469-7580.2011. 01435.x
    • (2011) J Anat , vol.219 , pp. 710-721
    • Suzuki, Y.1    Keiko, I.2    Kawakami, K.3
  • 38
    • 0027759447 scopus 로고
    • Hoxa2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest
    • 10.1016/0092-8674(93)90619-2 1:CAS:528:DyaK2cXhtVaqtbs%3D 7903600 10.1016/0092-8674(93)90619-2
    • Gendron-Maguire M, Mallo M, Zhang M, Gridley T (1993) Hoxa2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest. Cell 75:1317-1331. doi: 10.1016/0092-8674(93)90619-2
    • (1993) Cell , vol.75 , pp. 1317-1331
    • Gendron-Maguire, M.1    Mallo, M.2    Zhang, M.3    Gridley, T.4
  • 39
    • 0027739813 scopus 로고
    • A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa2, which acts as a selector gene
    • 10.1016/0092-8674(93)90620-6 1:CAS:528:DyaK2cXhtVaqtbg%3D 7903601 10.1016/0092-8674(93)90620-6
    • Rijli F, Mark M, Lakkaraju S, Dierich A, Dolle P, Chambon P (1993) A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa2, which acts as a selector gene. Cell 75:1333-1349. doi: 10.1016/0092-8674(93)90620-6
    • (1993) Cell , vol.75 , pp. 1333-1349
    • Rijli, F.1    Mark, M.2    Lakkaraju, S.3    Dierich, A.4    Dolle, P.5    Chambon, P.6
  • 40
    • 0031858666 scopus 로고    scopus 로고
    • Hoxa-2 restricts the chondrogenic domain and inhibits bone formation during development of the branchial area
    • 1:CAS:528:DyaK1cXlsV2gtLo%3D 9636074 ISSN: 0950-1991
    • Kanzler B, Kuschert SJ, Liu YH, Mallo M (1998) Hoxa-2 restricts the chondrogenic domain and inhibits bone formation during development of the branchial area. Development 125:2587-2597 ISSN: 0950-1991
    • (1998) Development , vol.125 , pp. 2587-2597
    • Kanzler, B.1    Kuschert, S.J.2    Liu, Y.H.3    Mallo, M.4
  • 41
    • 0033428616 scopus 로고    scopus 로고
    • Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants
    • 1:CAS:528:DyaK1MXotV2lsb4%3D 10529419 ISSN: 0950-1991
    • Barrow JR, Capecchi MR (1999) Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants. Development 126:5011-5026 ISSN: 0950-1991
    • (1999) Development , vol.126 , pp. 5011-5026
    • Barrow, J.R.1    Capecchi, M.R.2
  • 42
    • 0041976079 scopus 로고    scopus 로고
    • Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Pitx1
    • 10.1242/dev.00554 1:CAS:528:DC%2BD3sXms1WhtLY%3D 12810588 10.1242/dev.00554
    • Bobola N, Carapuco M, Ohnemus S, Kanzler B, Leibbrandt A, Neubuser A, Drouin J, Mallo M (2003) Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Pitx1. Development 130:3403-3414. doi: 10.1242/dev.00554
    • (2003) Development , vol.130 , pp. 3403-3414
    • Bobola, N.1    Carapuco, M.2    Ohnemus, S.3    Kanzler, B.4    Leibbrandt, A.5    Neubuser, A.6    Drouin, J.7    Mallo, M.8
  • 43
    • 0033397681 scopus 로고    scopus 로고
    • Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
    • 10.1101/gad.13.23.3136 1:CAS:528:DC%2BD3cXhtFOhtA%3D%3D 10.1101/gad.13.23.3136
    • Trumpp A, Depew MJ, Rubenstein JL, Bishop JM, Martin GR (1999) Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Gen Dev 13:3136-3148. doi: 10.1101/gad.13.23.3136
    • (1999) Gen Dev , vol.13 , pp. 3136-3148
    • Trumpp, A.1    Depew, M.J.2    Rubenstein, J.L.3    Bishop, J.M.4    Martin, G.R.5
  • 44
    • 0036800025 scopus 로고    scopus 로고
    • Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse
    • 1:CAS:528:DC%2BD38XotFGls7g%3D 12223417 ISSN: 0950-1991
    • Abu-Issa R, Smyth G, Smoak I, Yamamura K, Meyers EN (2002) Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse. Development 129:4613-4625 ISSN: 0950-1991
    • (2002) Development , vol.129 , pp. 4613-4625
    • Abu-Issa, R.1    Smyth, G.2    Smoak, I.3    Yamamura, K.4    Meyers, E.N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.