Comparison of real-time PCR and antigen assays for detection of hepatitis e virus in blood donors

Journal of Clinical Microbiology

Volumn 52, Issue 6, 2014, Pages 2150-2156

  Vollmer, T ^a   Knabbe, C ^a   Dreier, J ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN M; VIRUS ANTIGEN; VIRUS RNA; DIAGNOSTIC KIT;

ANTIGEN DETECTION; ARTICLE; BLOOD DONOR; DISEASE COURSE; EARLY DIAGNOSIS; GENOTYPE; HEPATITIS E; HEPATITIS E VIRUS; HUMAN; IMMUNOASSAY; INDUSTRIALIZATION; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SENSITIVITY ANALYSIS; SEROCONVERSION; SEROLOGY; VIREMIA; VIRUS DETECTION; ADULT; BLOOD; COMPARATIVE STUDY; DIAGNOSTIC KIT; EVALUATION STUDY; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROCEDURES; SENSITIVITY AND SPECIFICITY; VIROLOGY; YOUNG ADULT;

ADULT; ANTIGENS, VIRAL; BLOOD; BLOOD DONORS; HEPATITIS E; HEPATITIS E VIRUS; HUMANS; IMMUNOASSAY; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; REAGENT KITS, DIAGNOSTIC; RNA, VIRAL; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84901670766     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.03578-13     Document Type: Article

References (47)

1. Borgen K, Herremans T, Duizer E, Vennema H, Rutjes S, Bosman A, de Roda Husman AM, Koopmans M. 2008. Non-travel related hepatitis E virus genotype 3 infections in the Netherlands; a case series 2004-2006. BMC Infect. Dis. 8:61. http://dx.doi.org/10.1186/1471-2334-8-61
2. Adlhoch C, Kaiser M, Pauli G, Koch J, Meisel H. 2009. Indigenous hepatitis E virus infection of a plasma donor in Germany. Vox Sang. 97: 303-308. http://dx.doi.org/10.1111/j.1423-0410.2009.01211.x.
3. Lu L, Li C, Hagedorn CH. 2006. Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis. Rev. Med. Virol. 16:5-36. http://dx.doi.org/10.1002/rmv.482 (Pubitemid 43133591)
4. Mansuy JM, Peron JM, Abravanel F, Poirson H, Dubois M, Miedouge M, Vischi F, Alric L, Vinel JP, Izopet J. 2004. Hepatitis E in the south west of France in individuals who have never visited an endemic area. J. Med. Virol. 74:419-424. http://dx.doi.org/10.1002/jmv.20206 (Pubitemid 39281640)
5. Purcell RH, Emerson SU. 2008. Hepatitis E: an emerging awareness of an old disease. J. Hepatol. 48:494-503. http://dx.doi.org/10.1016/j.jhep.2007.12. 008
6. Guthmann JP, Klovstad H, Boccia D, Hamid N, Pinoges L, Nizou JY, Tatay M, Diaz F, Moren A, Grais RF, Ciglenecki I, Nicand E, Guerin PJ. 2006. A large outbreak of hepatitis E among a displaced population in Darfur, Sudan, 2004: the role of water treatment methods. Clin. Infect. Dis. 42:1685-1691. http://dx.doi.org/10.1086/504321 (Pubitemid 43839431)
7. Rutjes SA, Lodder WJ, Lodder-Verschoor F, van den Berg HH, Vennema H, Duizer E, Koopmans M, de Roda Husman AM. 2009. Sources of hepatitis E virus genotype 3 in The Netherlands. Emerg. Infect. Dis. 15:381-387. http://dx.doi.org/10.3201/eid1503.071472
8. Kamar N, Izopet J, Rostaing L. 2013. Hepatitis E virus infection. Curr. Opin. Gastrenterol. 29:271-278. http://dx.doi.org/10.1097/MOG.0b013e32835ff238
9. Clemente-Casares P, Pina S, Buti M, Jardi R, Martin M, Bofill-Mas S, Girones R. 2003. Hepatitis E virus epidemiology in industrialized countries. Emerg. Infect. Dis. 9:448-454. http://dx.doi.org/10.3201/eid0904.020351 (Pubitemid 37070411)
10. Hsieh SY, Meng XJ, Wu YH, Liu ST, Tam AW, Lin DY, Liaw YF. 1999. Identity of a novel swine hepatitis E virus in Taiwan forming a monophyletic group with Taiwan isolates of human hepatitis E virus. J. Clin. Microbiol. 37:3828-3834
11. Krumbholz A, Mohn U, Lange J, Motz M, Wenzel JJ, Jilg W, Walther M, Straube E, Wutzler P, Zell R. 2012. Prevalence of hepatitis E virusspecific antibodies in humans with occupational exposure to pigs. Med. Microbiol. Immunol. 201:239-244. http://dx.doi.org/10.1007/s00430-011-0210-5
12. Matsuda H, Okada K, Takahashi K, Mishiro S. 2003. Severe hepatitis E virus infection after ingestion of uncooked liver from a wild boar. J. Infect. Dis. 188:944. http://dx.doi.org/10.1086/378074 (Pubitemid 37176043)
13. Yazaki Y, Mizuo H, Takahashi M, Nishizawa T, Sasaki N, Gotanda Y, Okamoto H. 2003. Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food. J. Gen. Virol. 84:2351-2357. http://dx.doi.org/10.1099/vir.0.19242-0 (Pubitemid 37063123)
14. Schlosser B, Stein A, Neuhaus R, Pahl S, Ramez B, Kruger DH, Berg T, Hofmann J. 2012. Liver transplant from a donor with occult HEV infection induced chronic hepatitis and cirrhosis in the recipient. J. Hepatol. 56:500-502. http://dx.doi.org/10.1016/j.jhep.2011.06.021
15. Kamar N, Selves J, Mansuy JM, Ouezzani L, Peron JM, Guitard J, Cointault O, Esposito L, Abravanel F, Danjoux M, Durand D, Vinel JP, Izopet J, Rostaing L. 2008. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N. Engl. J. Med. 358:811-817. http://dx.doi.org/10.1056/NEJMoa0706992 (Pubitemid 351281642)
16. Legrand-Abravanel F, Kamar N, Sandres-Saune K, Garrouste C, Dubois M, Mansuy JM, Muscari F, Sallusto F, Rostaing L, Izopet J. 2010. Characteristics of autochthonous hepatitis E virus infection in solid-organ transplant recipients in France. J. Infect. Dis. 202:835-844. http://dx.doi.org/10.1086/655899
17. Boxall E, Herborn A, Kochethu G, Pratt G, Adams D, Ijaz S, Teo CG. 2006. Transfusion-transmitted hepatitis E in a ?nonhyperendemic? country. Transfus. Med. 16:79-83. http://dx.doi.org/10.1111/j.1365-3148 .2006.00652.x.
18. Colson P, Coze C, Gallian P, Henry M, De Micco P, Tamalet C. 2007. Transfusion-associated hepatitis E, France. Emerg. Infect. Dis. 13:648-649. http://dx.doi.org/10.3201/eid1304.061387
19. Matsubayashi K, Kang JH, Sakata H, Takahashi K, Shindo M, Kato M, Sato S, Kato T, Nishimori H, Tsuji K, Maguchi H, Yoshida J, Maekubo H, Mishiro S, Ikeda H. 2008. A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route. Transfusion 48:1368-1375. http://dx.doi.org/10.1111/j.1537-2995.2008.01722.x.
20. Matsubayashi K, Nagaoka Y, Sakata H, Sato S, Fukai K, Kato T, Takahashi K, Mishiro S, Imai M, Takeda N, Ikeda H. 2004. Transfusiontransmitted hepatitis E caused by apparently indigenous hepatitis E virus strain in Hokkaido, Japan. Transfusion 44:934-940. http://dx.doi.org/10.1111/j.1537-2995.2004.03300.x. (Pubitemid 38738426)
21. Dreier J, Juhl D. 2014. Autochthonous hepatitis E virus infections: a new transfusion-associated risk? Transfus. Med. Hemother. 41:29-39. http://dx.doi.org/10.1159/000357098
22. Baylis SA, Gartner T, Nick S, Ovemyr J, Blumel J. 2012. Occurrence of hepatitis E virus RNA in plasma donations from Sweden, Germany and the United States. Vox Sang. 103:89-90. http://dx.doi.org/10.1111/j.1423-0410.2011.01583.x.
23. Baylis SA, Koc O, Nick S, Blumel J. 2012. Widespread distribution of hepatitis E virus in plasma fractionation pools. Vox Sang. 102:182-183. http://dx.doi.org/10.1111/j.1423-0410.2011.01527.x.
24. Corman VM, Drexler JF, Eckerle I, Roth WK, Drosten C, Eis-Hubinger AM. 2013. Zoonotic hepatitis E virus strains in German blood donors. Vox Sang. 104:179-180. http://dx.doi.org/10.1111/j.1423-0410.2012.01638.x.
25. Vollmer T, Diekmann J, Johne R, Eberhardt M, Knabbe C, Dreier J. 2012. Novel approach for the detection of hepatitis E virus infection in German blood donors. J. Clin. Microbiol. 50:2708-2713. http://dx.doi.org/10.1128/JCM.01119-12
26. Takahashi M, Kusakai S, Mizuo H, Suzuki K, Fujimura K, Masuko K, Sugai Y, Aikawa T, Nishizawa T, Okamoto H. 2005. Simultaneous detection of immunoglobulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) is highly specific for diagnosis of acute HEV infection. J. Clin. Microbiol. 43:49-56. http://dx.doi.org/10.1128/JCM.43.1.49-56 .2005 (Pubitemid 40096279)
27. Tian DY, Chen Y, Xia NS. 2006. Significance of serum IgA in patients with acute hepatitis E virus infection. World J. Gastroenterol. 12:3919-3923. http://www.wjgnet.com/1007-9327/12/3919.asp. (Pubitemid 44028410)
28. Gupta E, Pandey P, Pandey S, Sharma MK, Sarin SK. 2013. Role of hepatitis E virus antigen in confirming active viral replication in patients with acute viral hepatitis E infection. J. Clin. Virol. 58:374-377. http://dx.doi.org/10. 1016/j.jcv.2013.07.019
29. Majumdar M, Singh MP, Pujhari SK, Bhatia D, Chawla Y, Ratho RK. 2013. Hepatitis E virus antigen detection as an early diagnostic marker: report from India. J. Med. Virol. 85:823-827. http://dx.doi.org/10.1002/jmv.23529
30. Zhang F, Li X, Li Z, Harrison TJ, Chong H, Qiao S, Huang W, Zhang H, Zhuang H, Wang Y. 2006. Detection of HEV antigen as a novel marker for the diagnosis of hepatitis E. J. Med. Virol. 78:1441-1448. http://dx.doi.org/10. 1002/jmv.20717 (Pubitemid 44533873)
31. Kamar N, Rostaing L, Legrand-Abravanel F, Izopet J. 2013. How should hepatitis E virus infection be defined in organ-transplant recipients? Am. J. Transplant. 13:1935-1936. http://dx.doi.org/10.1111/ajt.12253
32. Baylis SA, Blümel J, Mizusawa S, Matsubayashi K, Sakata H, Okada Y, Nübling CM, Hanschmann KM, HEV Collaborative Study Group. 2013. World Health Organization International Standard to harmonize assays for detection of hepatitis E virus RNA. Emerg. Infect. Dis. 19:729-735. http://dx.doi.org/10. 3201/eid1905.121845
33. Guo QS, Yan Q, Xiong JH, Ge SX, Shih JW, Ng MH, Zhang J, Xia NS. 2010. Prevalence of hepatitis E virus in Chinese blood donors. J. Clin. Microbiol. 48:317-318. http://dx.doi.org/10.1128/JCM.01466-09
34. Ijaz S, Szypulska R, Tettmar KI, Kitchen A, Tedder RS. 2012. Detection of hepatitis E virus RNA in plasma mini-pools from blood donors in England. Vox Sang. 102:272. http://dx.doi.org/10.1111/j.1423-0410.2011.01554.x.
35. Beale MA, Tettmar K, Szypulska R, Tedder RS, Ijaz S. 2011. Is there evidence of recent hepatitis E virus infection in English and North Welsh blood donors? Vox Sang. 100:340-342. http://dx.doi.org/10.1111/j.1423-0410.2010.01412. x.
36. Dalton HR, Hazeldine S, Banks M, Ijaz S, Bendall R. 2007. Locally acquired hepatitis E in chronic liver disease. Lancet 369:1260. http://dx.doi.org/10.1016/S0140-6736(07)60595-9 (Pubitemid 46566523)
37. Péron JM, Bureau C, Poirson H, Mansuy JM, Alric L, Selves J, Dupuis E, Izopet J, Vinel JP. 2007. Fulminant liver failure from acute autochthonous hepatitis E in France: description of seven patients with acute hepatitis E and encephalopathy. J. Viral Hepat. 14:298-303. http://dx.doi.org/ 10.1111/j.1365-2893.2007.00858.x. (Pubitemid 46587857)
38. Boccia D, Guthmann JP, Klovstad H, Hamid N, Tatay M, Ciglenecki I, Nizou JY, Nicand E, Guerin PJ. 2006. High mortality associated with an outbreak of hepatitis E among displaced persons in Darfur, Sudan. Clin. Infect. Dis. 42:1679-1684. http://dx.doi.org/10.1086/504322 (Pubitemid 43839430)
39. Christensen PB, Engle RE, Hjort C, Homburg KM, Vach W, Georgsen J, Purcell RH. 2008. Time trend of the prevalence of hepatitis E antibodies among farmers and blood donors: a potential zoonosis in Denmark. Clin. Infect. Dis. 47:1026-1031. http://dx.doi.org/10.1086/591970
40. Gérolami R, Moal V, Picard C, Colson P. 2009. Hepatitis E virus as an emerging cause of chronic liver disease in organ transplant recipients. J. Hepatol. 50:622-624. http://dx.doi.org/10.1016/j.jhep.2008.12.008
41. Juhl D, Baylis SA, Blumel J, Gorg S, Hennig H. 2014. Seroprevalence and incidence of hepatitis E virus infection in German blood donors. Transfusion 54:49-56. http://dx.doi.org/10.1111/trf.12121
42. Abravanel F, Chapuy-Regaud S, Lhomme S, Dubois M, Peron JM, Alric L, Rostaing L, Kamar N, Izopet J. 2013. Performance of two commercial assays for detecting hepatitis E virus RNA in acute or chronic infections. J. Clin. Microbiol. 51:1913-1916. http://dx.doi.org/10.1128/JCM.00661-13
43. Baylis SA, Hanschmann KM, Blumel J, Nubling CM. 2011. Standardization of hepatitis E virus (HEV) nucleic acid amplification techniquebased assays: an initial study to evaluate a panel of HEV strains and investigate laboratory performance. J. Clin. Microbiol. 49:1234-1239. http://dx.doi.org/10.1128/JCM. 02578-10
44. Abravanel F, Sandres-Saune K, Lhomme S, Dubois M, Mansuy JM, Izopet J. 2012. Genotype 3 diversity and quantification of hepatitis E virus RNA. J. Clin. Microbiol. 50:897-902. http://dx.doi.org/10.1128/JCM.05942-11
45. Tam AW, Smith MM, Guerra ME, Huang CC, Bradley DW, Fry KE, Reyes GR. 1991. Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome. Virology 185:120-131. http://dx.doi.org/10.1016/0042- 6822(91)90760-9
46. Zhao C, Li L, Harrison TJ, Wang Q, Song A, Fan J, Ma H, Zhang C, Wang Y. 2009. Relationships among viral diagnostic markers and markers of liver function in acute hepatitis E. J. Gastroenterol. 44:139-145. http://dx.doi.org/10.1007/ s00535-008-2281-7
47. Chai N, Chang HE, Nicolas E, Han Z, Jarnik M, Taylor J. 2008. Properties of subviral particles of hepatitis B virus. J. Virol. 82:7812-7817. http://dx.doi.org/10.1128/JVI.00561-08.