Rituximab fails where eculizumab restores renal function in C3nef-related DDD

Pediatric Nephrology

Volumn 29, Issue 6, 2014, Pages 1107-1111

  Rousset Rouvière, Caroline ^a   Cailliez, Mathilde ^a   Garaix, Florentine ^a   Bruno, Daniele ^a   Laurent, Daniel ^a   Tsimaratos, Michel ^a  

^a TIMONE HOSPITAL   (France)

Author keywords

C3 glomerulopathy; Complement; Dense deposit disease; Eculizumab; Kidney; Membranoproliferative glomerulonephritis

Indexed keywords

CORTICOSTEROID; ECULIZUMAB; METHYLPREDNISOLONE SODIUM SUCCINATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NEPHRITIC FACTOR; RITUXIMAB; MONOCLONAL ANTIBODY;

ABSENCE OF SIDE EFFECTS; ACUTE KIDNEY FAILURE; ARTICLE; CASE REPORT; CHILD; COMPLEMENT ALTERNATIVE PATHWAY; CORTICOSTEROID THERAPY; DENSE DEPOSIT DISEASE; DRUG TREATMENT FAILURE; ELECTRON MICROSCOPY; GLOMERULOPATHY; GLOMERULOSCLEROSIS; GLOMERULUS BASEMENT MEMBRANE; HEMATURIA; HUMAN; KIDNEY BIOPSY; KIDNEY FUNCTION; MALE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; PRIORITY JOURNAL; PROTEINURIA; RECURRENT DISEASE; RENAL REPLACEMENT THERAPY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SCHOOL CHILD; GLOMERULONEPHRITIS, MEMBRANOPROLIFERATIVE; IMMUNOLOGY; PATHOLOGY;

ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; CHILD; COMPLEMENT C3 NEPHRITIC FACTOR; GLOMERULONEPHRITIS, MEMBRANOPROLIFERATIVE; HUMANS; MALE;

EID: 84901641827     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-013-2711-5     Document Type: Article

References (24)

1. Angelo JR, Bell CS, Braun MC (2011) Allograft failure in kidney transplant recipients with membranoproliferative glomerulonephritis. Am J Kidney Dis 57(2):291-299
2. Braun MC, Stablein DM, Hamiwka LA, Bell L, Bartosh SM, Strife CF (2005) Recurrence of membranoproliferative glomerulonephritis type II in renal allografts: The North American Pediatric Renal Transplant Cooperative Study experience. J Am Soc Nephrol 16(7):2225-2233
3. Licht C, Fremeaux-Bacchi V (2009) Hereditary and acquired complement dysregulation in membranoproliferative glomerulonephritis. Thromb Haemost 101:271-278
4. Fakhouri F, Fremeaux-Bacchi V, Noel LH, Cook HT, Pickering MC (2010) C3 glomerulopathy: a new classification. Nat Rev Nephrol 6:494-499
5. Sethi S, Fervenza FC, Zhang Y, Nasr SH, Leung N, Vrana J, Cramer C, Nester CM, Smith RJ (2011) Proliferative glomerulonephritis secondary to dysfunction of the alternative pathway of complement. Clin J Am Soc Nephrol 6:1009-1017
6. Skerka C, Licht C, Mengel M, Uzonyi B, Strobel S, Zipfel PF, Józsi M (2009) Autoimmune forms of thrombotic microangiopathy and membranoproliferative glomerulonephritis: indications for a disease spectrum and common pathogenic principles. Mol Immunol 46:2801-2807
7. Goodship TH, Pappworth IY, Toth T, Denton M, Houlberg K, McCormick F, Warland D, Moore I, Hunze EM, Staniforth SJ, Hayes C, Cavalcante DP, Kavanagh D, Strain L, Herbert AP, Schmidt CQ, Barlow PN, Harris CL, Marchbank KJ (2012) Factor H autoantibodies in membranoproliferative glomerulonephritis. Mol Immunol 52(3-4):200-206
8. Leroy V, Fremeaux-Bacchi V, Peuchmaur M, Baudouin V, Deschênes G, Macher MA, Loirat C (2011) Membranoproliferative glomerulonephritis with C3NeF and genetic complement dysregulation. Pediatr Nephrol 26(3):419-424
9. Habbig S, Mihatsch MJ, Heinen S, Beck B, Emmel M, Skerka C, Kirschfink M, Hoppe B, Zipfel PF, Licht C (2009) C3 deposition glomerulopathy due to a functional factor H defect. Kidney Int 75:1230-1234
10. Servais A, Noel LH, Roumenina LT, LeQuintrec M, Ngo S, Dragon Servais A, Noël LH, Roumenina LT, Le Quintrec M, Ngo S, Dragon-Durey MA, Macher MA, Zuber J, Karras A, Provot F, Moulin B, Grünfeld JP, Niaudet P, Lesavre P, Frémeaux-Bacchi V (2012) Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies. Kidney Int 82(4):454-464
11. Lu DF, Moon M, Lanning LD, McCarthy AM, Smith RJ (2012) Clinical features and outcomes of 98 children and adults with dense deposit disease. Pediatr Nephrol 27(5):773-781
12. Nester CM, Smith RJ (2013) Treatment options for C3 glomerulopathy. Curr Opin Nephrol Hypertens 22(2):231-237
13. McCaughan JA, O'Rourke DM, Courtney AE (2012) Recurrent dense deposit disease after renal transplantation: an emerging role for complementary therapies. Am J Transplant 12:1046-1051
14. Gurkan S, Fyfe B, Weiss L, Xiao X, Zhang Y, Smith RJ (2013) Eculizumab and recurrent C3 glomerulonephritis. Pediatr Nephrol 28:1975-1981
15. Dillon JJ, Hladunewich M, Haley WE, Reich HN, Cattran DC, Fervenza FC (2012) Rituximab therapy for Type I membranoproliferative glomerulonephritis. Clin Nephrol 77(4):290-295
16. Zuber J, Fakhouri F, Roumenina Lubka T, Loirat C, Fremeaux-Bacchi V (2012) Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies. Nat Rev Nephrol 8(11):643-657
17. Hillmen P, Young NS, Schubert J, Brodsky RA, Socié G, Muus P, Röth A, Szer J, Elebute MO, Nakamura R, Browne P, Risitano AM, Hill A, Schrezenmeier H, Fu CL, Maciejewski J, Rollins SA, Mojcik CF, Rother RP, Luzzatto L (2006) The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med 355(12):1233-1243
18. Gruppo RA, Rother RP (2009) Eculizumab for congenital atypical hemolytic-uremic syndrome. N Engl J Med 360(5):544-546
19. Vivarelli M, Pasini A, Emma F (2012) Eculizumab for the treatment of Dense-Deposit disease. N Engl J Med 366(12):1163-1165
20. Daina E, Noris M, Remuzzi G (2012) Eculizumab in a patient with dense-deposit disease. N Engl J Med 366:1161-1163
21. Radhakrishnan S, Lunn A, Kirschfink M, Thorner P, Hebert D, Langlois V, Pluthero F, Licht C (2012) Eculizimab and refractory Membranoproliferative Glomerulonephritis. N Engl J Med 366(12):1165-1167
22. Cravedi P (2012) Role of monoclonal antibodies in the treatment of immune-mediated kidney disease: the state of the art. G Ital Nefrol 29(3):274-282
23. Herlitz LC, Bomback AS, Markowitz GS, Stokes MB, Smith RN, Colvin RB, Appel GB, D' Agati VD (2012) Pathology after eculizumab in dense deposit disease and C3 GN. J Am Soc Nephrol 23(7):1229-1237
24. Bomback AS, Smith RJ, Barile GR, Zhang Y, Heher EC, Herlitz L, Stokes MB, Markowitz GS, D' Agati VD, Canetta PA, Radhakrishnan J, Appel GB (2012) Eculizumab for dense deposit disease and C3 glomerulonephritis. Clin J Am Soc Nephrol 7(5):748-756