Serum and CSF biomarkers in acute pediatric neurological disorders

Brain and Development

Volumn 36, Issue 6, 2014, Pages 489-495

  Shiihara, Takashi ^a   Miyake, Taeko ^a   Izumi, Sakiko ^a   Sugihara, Susumu ^a   Watanabe, Mio ^a   Takanashi, Jun ichi ^b   Kubota, Masaya ^c   Kato, Mitsuhiro ^d  

^a Gunma Children's Medical Center   (Japan)

^b KAMEDA MEDICAL CENTER   (Japan)

^c NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^d YAMAGATA UNIVERSITY   (Japan)

Author keywords

Area under the curve; Neuron specific enolase; Receiver operating characteristic curves; S100B; Total tau

Indexed keywords

NEURON SPECIFIC ENOLASE; PROTEIN S100B; TAU PROTEIN; BIOLOGICAL MARKER; ENOLASE; MAPT PROTEIN, HUMAN; S100B PROTEIN, HUMAN;

ACUTE BRAIN DISEASE; ACUTE DISEASE; ACUTE DISSEMINATED ENCEPHALOMYELITIS; ACUTE PEDIATRIC NEUROLOGICAL DISORDER; AFEBRILE SEIZURE; AREA UNDER THE CURVE; ARTICLE; ASEPTIC MENINGITIS; BRAIN DISEASE; CHILD; CHILDHOOD DISEASE; CONTROL NEUROLOGICAL DISORDER; CONTROLLED STUDY; CONVULSION; ENCEPHALITIS; FEBRILE CONVULSION; FEMALE; FOCAL EPILEPSY; GASTROENTERITIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MENINGITIS; NEUROLOGIC DISEASE; PREDICTION; PROGNOSIS; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; RECEIVER OPERATING CHARACTERISTIC; SEIZURE; SEPTIC MENINGITIS; VALIDITY; BLOOD; CEREBROSPINAL FLUID; INFANT; METABOLISM; NERVOUS SYSTEM DISEASES; PRESCHOOL CHILD; SENSITIVITY AND SPECIFICITY;

ACUTE DISEASE; AREA UNDER CURVE; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; MALE; NERVOUS SYSTEM DISEASES; PHOSPHOPYRUVATE HYDRATASE; PROGNOSIS; ROC CURVE; S100 CALCIUM BINDING PROTEIN BETA SUBUNIT; SENSITIVITY AND SPECIFICITY; TAU PROTEINS;

EID: 84901633325     PISSN: 03877604     EISSN: 18727131     Source Type: Journal    
DOI: 10.1016/j.braindev.2013.06.011     Document Type: Article

References (23)

1. Fenichel G.M. Clinical pediatric neurology 2009, Saunders, Philadelphia. 6th ed.
2. Yuksel D., Yilmaz D., Uyar N.Y., Senbil N., Gurer Y., Anlar B. Tau proteins in the cerebrospinal fluid of patients with subacute sclerosing panencephalitis. Brain Dev 2010, 32:467-471.
3. Shiihara T., Miyake T., Izumi S., Watanabe M., Kamayachi K., Kodama K., et al. Serum and cerebrospinal fluid S100B, neuron-specific enolase, and total tau protein in acute encephalopathy with biphasic seizures and late reduced diffusion: a diagnostic validity. Pediatr Int 2012, 54:52-55.
4. Tanuma N., Miyata R., Kumada S., Kubota M., Takanashi J., Okumura A., et al. The axonal damage marker tau protein in the cerebrospinal fluid is increased in patients with acute encephalopathy with biphasic seizures and late reduced diffusion. Brain Dev 2010, 32:435-439.
5. Borusiak P., Herbold S. Serum neuron-specific enolase in children with febrile seizures: time profile and prognostic implications. Brain Dev 2003, 25:272-274.
6. Rodríguez-Núñez A., Cid E., Rodríguez-García J., Camiña F., Rodríguez-Segade S., Castro-Gago M. Cerebrospinal fluid purine metabolite and neuron-specific enolase concentrations after febrile seizures. Brain Dev 2000, 22:427-431.
7. Oyazato Y., Shiihara T., Kusunoki S., Adachi M., Ohnishi N., Taniguchi H., et al. A case of anti-GA1 antibody-positive Fisher syndrome with elevated tau protein in cerebrospinal fluid. Brain Dev 2012, 34:329-332.
8. Oka M, Hasegawa S, Matsushige T, Inoue H, Kajimoto M, Ishikawa N, et al. Tau protein concentrations in the cerebrospinal fluid of children with acute disseminated encephalomyelitis. Brain Dev 2014;36:16-20.
9. Wunderlich M.T., Lins H., Skalej M., Wallesch C.W., Goertler M. Neuron-specific enolase and tau protein as neurobiochemical markers of neuronal damage are related to early clinical course and long-term outcome in acute ischemic stroke. Clin Neurol Neurosurg 2006, 108:558-563.
10. Cnossen M.H., Aarsen F.K., Akker S.L.J., Danen R., Appel I.M., Steyerberg E.W. Paediatric arterial ischaemic stroke: functional outcome and risk factors. Dev Med Child Neurol 2010, 52:394-399.
11. Robin X., Turck N., Hainard A., Tiberti N., Lisacek F., Sanchez J.C., et al. PROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics 2011, 12:77.
12. Ray P., Le Manach Y., Riou B., Houle T.T. Statistical evaluation of a biomarker. Anesthesiology 2010, 112:1023-1040.
13. Hoshino A., Saitoh M., Oka A., Okumura A., Kubota M., Saito Y., et al. Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes. Brain Dev 2012, 34:337-343.
14. Mizuguchi M., Yamanouchi H., Ichiyama T., Shiomi M. Acute encephalopathy associated with influenza and other viral infections. Acta Neurol Scand Suppl 2007, 186:45-56.
15. Kawano G., Oshige K., Syutou S., Koteda Y., Yokoyama T., Kim B.G., et al. Benign infantile convulsions associated with mild gastroenteritis: a retrospective study of 39 cases including virological tests and efficacy of anticonvulsants. Brain Dev 2007, 29:617-622.
16. Kleine T.O., Benes L., Zöfel P. Studies of the brain specificity of S100B and neuron-specific enolase (NSE) in blood serum of acute care patients. Brain Res Bull. 2003, 61:265-279.
17. Okumus N., Turkyilmaz C., Onal E.E., Atalay Y., Serdaroglu A., Elbeg S., et al. Tau and S100B proteins as biochemical markers of bilirubin-induced neurotoxicity in term neonates. Pediatr Neurol 2008, 39:245-252.
18. Noguchi-Shinohara M., Hamaguchi T., Nozaki I., Sakai K., Yamada M. Serum tau protein as a marker for the diagnosis of Creutzfeldt-Jakob disease. J Neurol 2011, 258:1464-1468.
19. Hu H.T., Xiao F., Yan Y.Q., Wen S.Q., Zhang L. The prognostic value of serum tau in patients with intracerebral hemorrhage. Clin Biochem 2012, 45:1320-1324.
20. Protas P.T., Muszynska-Roslan K., Holownia A., Grabowska A., Wielgat P., Krawczuk-Rybak M., et al. Negative correlation between cerebrospinal fluid tau protein and cognitive functioning in children with acute lymphoblastic leukemia. Pediatr Blood Cancer 2009, 53:105-108.
21. Liliang P.C., Liang C.L., Lu K., Wang K.W., Weng H.C., Hsieh C.H., et al. Relationship between injury severity and serum tau protein levels in traumatic brain injured rats. Resuscitation 2010, 81:1205-1208.
22. Cata J.P., Abdelmalak B., Farag E. Neurological biomarkers in the perioperative period. Br J Anaesth 2011, 107:844-858.
23. Akobeng A.K. Understanding diagnostic tests 1: sensitivity, specificity and predictive values. Acta Paediatr 2007, 96:338-341.