Performance of a 62Zn/62Cu microgenerator in kit-based synthesis and delivery of [62Cu]Cu-ETS for PET perfusion imaging

Applied Radiation and Isotopes

Volumn 91, Issue , 2014, Pages 38-43

  Ng, Yen ^a   Lacy, Jeffrey L ^b   Fletcher, James W ^a   Green, Mark A ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PROPORTIONAL TECHNOLOGIES INC   (United States)

Author keywords

PET radiopharmaceuticals; Tumor perfusion

Indexed keywords

ZINC;

CLINICAL SITES; MICROGENERATORS; PATIENT DOSE; PERFUSION IMAGING; RADIOPHARMACEUTICAL SYNTHESIS; THIOSEMICARBAZONES; TUMOR PERFUSION;

COPPER;

COPPER 62; ETHYLGLYOXAL BIS(THIOSEMICARBAZONATO)COPPER C 62; RADIOISOTOPE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; ZINC 62; COPPER; ETHYLGLYOXAL BIS(THIOSEMICARBAZONATO)COPPER(II); ORGANOMETALLIC COMPOUND; THIOSEMICARBAZONE DERIVATIVE; ZINC;

ADVANCED CANCER; ARTICLE; CHEMICAL ANALYSIS; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSIMETRY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELUTION; HEAD AND NECK CANCER; HUMAN; IMAGE ANALYSIS; KIDNEY CARCINOMA; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; RADIATION DOSE DISTRIBUTION; RADIOACTIVITY; SCINTIGRAPHY; CHEMISTRY; DEVICES; DIAGNOSTIC USE; HEAD AND NECK TUMOR; KIDNEY TUMOR; PROCEDURES; SCINTISCANNING; SYNTHESIS;

COPPER RADIOISOTOPES; HEAD AND NECK NEOPLASMS; HUMANS; KIDNEY NEOPLASMS; ORGANOMETALLIC COMPOUNDS; PERFUSION IMAGING; POSITRON-EMISSION TOMOGRAPHY; RADIONUCLIDE GENERATORS; RADIOPHARMACEUTICALS; THIOSEMICARBAZONES; ZINC RADIOISOTOPES;

EID: 84901631411     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2014.05.006     Document Type: Article

References (27)

1. Baerga I.D., Maickel R.P., Green M.A. Subcellular-distribution of tissue radiocopper following intravenous administration of Cu-67 labeled Cu-PTSM. Nucl. Med. Biol. 1992, 19(6):697-701.
2. Basken N.E., Green M.A. Cu(II) bis(thiosemicarbazone) radiopharmaceutical binding to serum albumin: further definition of species dependence and associated substituent effects. Nucl. Med. Biol. 2009, 36(5):495-504.
3. Castle T.C., Maurer R.I., Sowrey F.E., Went M.J., Reynolds C.A., McInnes E.J., et al. Hypoxia-targeting copper bis(selenosemicarbazone) complexes: comparison with their sulfur analogues. J. Am. Chem. Soc. 2003, 125(33):10040-10049.
4. Finn R.D., Molinski V.J., Hupf H.B., Kramer H. Radionuclide Generators for Biomedical Applications (NAS-NS-3202) 1983, Technical Information Center, U.S. Department of Energy, Springfield, VA.
5. 15O]-water. J. Nucl. Med. 2014, 55(5):446. (supplement 1; meeting abstracts).
6. Fujibayashi Y., Matsumoto K., Yonekura Y., Konishi J., Yokoyama A. A new zinc-62/copper-62 generator as a copper-62 source for PET radiopharmaceuticals. J. Nucl. Med. 1989, 30(11):1838-1842.
7. Fujibayashi Y., Taniuchi H., Yonekura Y., Ohtani H., Konishi J., Yokoyama A. Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. J. Nucl. Med. 1997, 38(7):1155-1160.
8. 4-methylthiosemicarbazonato)copper(II): synthesis and evaluation as a positron emission tomography tracer for cerebral and myocardial perfusion. J. Nucl. Med. 1990, 31:1989-1996.
9. Green M.A., Mathias C.J., Willis L.R., Handa R.K., Lacy J.L., Miller M.A., et al. Assessment of Cu-ETS as a PET radiopharmaceutical for evaluation of regional renal perfusion. Nucl. Med. Biol. 2007, 34(3):247-255.
10. 62Cu-PTSM. J. Nucl. Med. 2000, 41(2):309-314.
11. IAEA, 2010. Production of long-lived parent radionuclides for generators: Ga-68, Sr-82, Sr-90 and W-188. IAEA Radioisotopes and Radiopharmaceuticals, Series no. 2. IAEA, Vienna.
12. ICRP, 1988. Radiation Dose to Patients from Radiopharmaceuticals, a Report of a Task Group of Committee 2 of the International Commission on Radiological Protection (ICRP Publication 53). Pergamon Press, Oxford.
13. John E.K., Green M.A. Structure-activity relationship for metal-labeled blood flow tracers: comparison of keto aldehyde bis(thiosemicarbazonato)copper(II) derivatives. J. Med. Chem. 1989, 33:1765-1770.
14. Kraus K.A., Moore G.E. Anion exchange studies. VI: The divalent transition elements manganese to zinc in hydrochloric acid. J. Am. Chem. Soc. 1952, 75:1460-1462.
15. 62Cu radiopharmaceuticals. J. Nucl. Med. 2006, 47(1):162.
16. Lacy, J.L., Guerrero, L., Chiu, R., Sun, L., Hall, L., Stone, C.K., 2007. PET imaging with 62Cu-ETS in a human clinical trial at the University of Wisconsin-Madison. In: IEEE Nuclear Science Symposium Conference 2007, pp. 4027-4030.
17. 15O-water PET. J. Nucl. Med. 2010, 51(2):587.
18. Lewis J.S., McCarthy D.W., McCarthy T.J., Fujibayashi Y., Welch M.J. Evaluation of Cu-64-ATSM in vitro and in vivo in a hypoxic tumor model. J. Nucl. Med. 1999, 40(1):177-183.
19. 62Cu-NOTA-NOC as a potential short-lived generator-based PET tracers for somatostatin receptor imaging. J. Nucl. Med. 2013, 54(1):1140.
20. Mathias C.J., Welch M.J., Raichle M.E., Mintun M.A., Lich L.L., Mcguire A.H., et al. Evaluation of a potential generator-produced PET tracer for cerebral perfusion imaging - single-pass cerebral extraction measurements and imaging with radiolabeled Cu-PTSM. J. Nucl. Med. 1990, 31(3):351-359.
21. Petering D.H. Carcinostic Copper Complexes 1980, Marcel Dekker, New York.
22. Robinson G.D., Zielinski F.W., Lee A.W. The zinc-62/copper-62 generator: a convenient source of copper-62 for radiopharmaceuticals. Int. J. Appl. Radiat. Isot. 1980, 31(2):111-116.
23. Shelton M.E., Green M.A., Mathias C.J., Welch M.J., Bergmann S.R. Kinetics of copper-PTSM in isolated hearts - a novel tracer for measuring blood-flow with positron emission tomography. J. Nucl. Med. 1989, 30(11):1843-1847.
24. Shelton M.E., Green M.A., Mathias C.J., Welch M.J., Bergmann S.R. Assessment of regional myocardial and renal blood-flow with copper-PTSM and positron emission tomography. Circulation 1990, 82(3):990-997.
25. 62Cu microgenerator system. J. Nucl. Med. 2008, 49(1):95.
26. Vavere A.L., Lewis J.S. Cu-ATSM: a radiopharmaceutical for the PET imaging of hypoxia. Dalton Trans. 2007, 43:4893-4902.
27. Zweit J., Goodall R., Cox M., Babich J.W., Potter G.A., Sharma H.L., et al. Development of a high-performance zinc-62/copper-62 radionuclide generator for positron emission tomography. Eur. J. Nucl. Med. 1992, 19(6):418-425.