Clinical and serologic correlates of anti-pm/scl antibodies in systemic sclerosis: A multicenter study of 763 patients

Arthritis and Rheumatology

Volumn 66, Issue 6, 2014, Pages 1608-1615

  D'Aoust, Julie ^a   Hudson, Marie ^a   Tatibouet, Solène ^a   Wick, James ^b   Mahler, Michael ^c   Baron, Murray ^a   Fritzler, Marvin J ^c  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c INOVA DIAGNOSTICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CENTROMERE ANTIBODY; CENTROMERE PROTEIN A ANTIBODY; CENTROMERE PROTEIN B ANTIBODY; CREATINE KINASE; JO 1 ANTIBODY; LA ANTIBODY; PM 1 ALPHA ANTIBODY; RNA POLYMERASE II ANTIBODY; RNA POLYMERASE III ANTIBODY; RO ANTIBODY; TOPOISOMERASE ANTIBODY; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CALCINOSIS; CANADA; CLINICAL FEATURE; COHORT ANALYSIS; COMPARATIVE STUDY; CORRELATION ANALYSIS; CREATINE KINASE BLOOD LEVEL; DEMOGRAPHY; DERMATOMYOSITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GASTROINTESTINAL DISEASE; GASTROINTESTINAL SYMPTOM; HUMAN; INTERSTITIAL LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; MIXED CONNECTIVE TISSUE DISEASE; MULTICENTER STUDY; ONSET AGE; PHENOTYPE; POLYMYOSITIS; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; RHEUMATOID ARTHRITIS; SEROLOGY; SJOEGREN SYNDROME; SKELETAL MUSCLE; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS;

ADULT; AGED; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, ANTINUCLEAR; BIOLOGICAL MARKERS; CANADA; COHORT STUDIES; DNA TOPOISOMERASES, TYPE I; EPITOPES; EXORIBONUCLEASES; EXOSOME MULTIENZYME RIBONUCLEASE COMPLEX; FEMALE; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RNA POLYMERASE III; SCLERODERMA, SYSTEMIC;

EID: 84901630150     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38428     Document Type: Article

References (26)

1. Ho KT, Reveille JD,. The clinical relevance of autoantibodies in scleroderma. Arthritis Res Ther 2003; 5: 80-93.
2. Mehra S, Walker J, Patterson K, Fritzler MJ,. Autoantibodies in systemic sclerosis. Autoimmun Rev 2013; 12: 340-54.
3. Steen VD,. Autoantibodies in systemic sclerosis. Semin Arthritis Rheum 2005; 35: 35-42.
4. Mahler M, Raijmakers R,. Novel aspects of autoantibodies to the PM/Scl complex: clinical, genetic and diagnostic insights. Autoimmun Rev 2007; 6: 432-7.
5. Oddis CV, Okano Y, Rudert WA, Trucco M, Duquesnoy RJ, Medsger TA Jr., Serum autoantibody to the nucleolar antigen PM-Scl: clinical and immunogenetic associations. Arthritis Rheum 1992; 35: 1211-7.
6. Mahler M, Fritzler MJ,. PM1-Alpha ELISA: the assay of choice for the detection of anti-PM/Scl autoantibodies? Autoimmun Rev 2009; 8: 373-8.
7. Hanke K, Bruckner CS, Dahnrich C, Huscher D, Komorowski L, Meyer W, et al. Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients. Arthritis Res Ther 2009; 11: R22.
8. Mierau R, Moinzadeh P, Riemekasten G, Melchers I, Meurer M, Reichenberger F, et al. Frequency of disease-associated and other nuclear autoantibodies in patients of the German Network for Systemic Scleroderma: correlation with characteristic clinical features. Arthritis Res Ther 2011; 13: R172.
9. Koschik RW II, Fertig N, Lucas MR, Domsic RT, Medsger TA Jr., Anti-PM-Scl antibody in patients with systemic sclerosis. Clin Exp Rheumatol 2012; 30: S12-6.
10. Brouwer R, Pruijn GJ, van Venrooij WJ,. The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma. Arthritis Res 2001; 3: 102-6.
11. Gelpi C, Alguero A, Angeles Martinez M, Vidal S, Juarez C, Rodriguez-Sanchez JL,. Identification of protein components reactive with anti-PM/Scl autoantibodies. Clin Exp Immunol 1990; 81: 59-64.
12. Alderuccio F, Chan EK, Tan EM,. Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex. J Exp Med 1991; 173: 941-52.
13. Mahler M, Raijmakers R, Dahnrich C, Bluthner M, Fritzler MJ,. Clinical evaluation of autoantibodies to a novel PM/Scl peptide antigen. Arthritis Res Ther 2005; 7: R704-13.
14. Marguerie C, Bunn CC, Copier J, Bernstein RM, Gilroy JM, Black CM, et al. The clinical and immunogenetic features of patients with autoantibodies to the nucleolar antigen PM-Scl. Medicine (Baltimore) 1992; 71: 327-36.
15. Jaskowski TD, Wilson A, Hill HR, Tebo AE,. Diagnostic assays for anti-PM/Scl IgG antibodies: heterogeneity in antibody response or lack of standardization? Clin Chim Acta 2011; 412: 1100-5.
16. Clements P, Lachenbruch P, Siebold J, White B, Weiner S, Martin R, et al. Inter and intraobserver variability of total skin thickness score (modified Rodnan TSS) in systemic sclerosis. J Rheumatol 1995; 22: 1281-5.
17. LeRoy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, Medsger TA Jr, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988; 15: 202-5.
18. Steele R, Hudson M, Lo E, Baron M, on behalf of the Canadian Scleroderma Research Group. Clinical decision rule to predict the presence of interstitial lung disease in systemic sclerosis. Arthritis Care Res (Hoboken) 2012; 64: 519-24.
19. Hsu VM, Moreyra AE, Wilson AC, Shinnar M, Shindler DM, Wilson JE, et al. Assessment of pulmonary arterial hypertension in patients with systemic sclerosis: comparison of noninvasive tests with results of right-heart catheterization. J Rheumatol 2008; 35: 458-65.
20. Medsger TA Jr, Silman AJ, Steen VD, Black CM, Akesson A, Bacon PA, et al. A disease severity scale for systemic sclerosis: development and testing. J Rheumatol 1999; 26: 2159-67.
21. Medsger TA Jr, Bombardieri S, Czirjak L, Scorza R, Della Rossa A, Bencivelli W,. Assessment of disease severity and prognosis. Clin Exp Rheumatol 2003; 21: S42-6.
22. Hudson M, Mahler M, Pope J, You D, Tatibouet S, Steele R, et al. Clinical correlates of CENP-A and CENP-B antibodies in a large cohort of patients with systemic sclerosis. J Rheumatol 2012; 39: 787-94.
23. Santiago M, Baron M, Hudson M, Burlingame RW, Fritzler MJ,. Antibodies to RNA polymerase III in systemic sclerosis detected by ELISA. J Rheumatol 2007; 34: 1528-34.
24. Bonroy C, Van Praet J, Smith V, Van Steendam K, Mimori T, Deschepper E, et al. Optimization and diagnostic performance of a single multiparameter lineblot in the serological workup of systemic sclerosis. J Immunol Methods 2012; 379: 53-60.
25. Villalta D, Imbastaro T, Di Giovanni S, Lauriti C, Gabini M, Turi MC, et al. Diagnostic accuracy and predictive value of extended autoantibody profile in systemic sclerosis. Autoimmun Rev 2012; 12: 114-20.
26. Wolfe JF, Adelstein E, Sharp GC,. Antinuclear antibody with distinct specificity for polymyositis. J Clin Invest 1977; 59: 176-8.