Diagnostic assays for Anti-PM/Scl IgG antibodies: Heterogeneity in antibody response or lack of standardization?

Clinica Chimica Acta

Volumn 412, Issue 11-12, 2011, Pages 1100-1105

  Jaskowski, Troy D ^a   Wilson, Andrew ^a   Hill, Harry R ^a,b   Tebo, Anne E ^a,b  

^a ARUP INSTITUTE FOR CLINICAL AND EXPERIMENTAL PATHOLOGY   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Anti PM Scl IgG; Antibodies; Diagnostic; Performance

Indexed keywords

ANTINUCLEAR ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; POLYMYOSITIS IMMUNOGLOBULIN G ANTIBODY; SCLERODERMA IMMUNOGLOBULIN G ANTIBODY; UNCLASSIFIED DRUG;

ADULT; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNODIFFUSION; IMMUNOPRECIPITATION; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; POLYMYOSITIS; PRIORITY JOURNAL; SCLERODERMA; SCREENING TEST; STANDARDIZATION;

ADULT; AUTOANTIGENS; BLOOD CHEMICAL ANALYSIS; EPITOPES; HUMANS; IMMUNOGLOBULIN G; IMMUNOLOGIC TECHNIQUES; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS;

EID: 79954997485     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2011.02.031     Document Type: Article

References (25)

1. Reichlin M., Maddison P.J., Targoff I., Bunch T., Arnett F., Sharp G., et al. Antibodies to a nuclear/nucleolar antigen in patients with polymyositis overlap syndromes. J Clin Immunol 1984, 4:40-44.
2. Alderuccio F., Chan E.K., Tan E.M. Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex. J Exp Med 1991, 173:941-952.
3. Blüthner M., Bautz F.A. Cloning and characterization of the cDNA coding for a polymyositis-scleroderma overlap syndromerelated nucleolar 100-kD protein. J Exp Med 1992, 176:973-980.
4. Brouwer R., Vree Egberts W.T., Hengstman G.J., Raijmakers R., van Engelen B.G., Seelig H.P., et al. Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. Arthritis Res 2002, 4:134-138.
5. Oddis C.V., Okano Y., Rudert W.A., Trucco M., Duquesnoy R.J., Medsger T.A. Serum autoantibody to the nucleolar antigen PM-Scl. Clinical and immunogenetic associations. Arthritis Rheum 1992, 35:1211-1217.
6. Brouwer R., Hengstman G.J., Vree Egberts W., Ehrfeld H., Bozic B., Ghirardello A., et al. Autoantibody profiles in the sera of European patients with myositis. Ann Rheum Dis 2001, 60:116-123.
7. Raijmakers R., Renz M., Wiemann C., Egberts W.V., Seelig H.P., van Venrooij W.J., et al. PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome. Arthritis Rheum 2004, 50:565-569.
8. Hanke K., Brückner C.S., Dähnrich C., Huscher D., Komorowski L., Meyer W., et al. Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients. Arthritis Res Ther 2009, 11:R22.
9. Marguerie C., Bunn C.C., Copier J., Bernstein R.M., Gilroy J.M., Black C.M., et al. The clinical and immunogenetic features of patients with autoantibodies to the nucleolar antigen PM-Scl. Medicine 1992, 71:327-336.
10. Vandergheynst F., Ocmant A., Sordet C., Humbel R.L., Goetz J., Roufosse F., et al. Anti-pm/scl antibodies in connective tissue disease: clinical and biological assessment of 14 patients. Clin Exp Rheumatol 2006, 24:129-133.
11. Kuwana M., Kaburaki J., Okano Y., Tojo T., Homma M. Clinical and prognostic associations based on serum antinuclear antibodies in Japanese patients with systemic sclerosis. Arthritis Rheum 1994, 37:75-83.
12. Harvey G., Black C., Maddison P., McHugh N. Characterization of antinucleolar antibody reactivity in patients with systemic sclerosis and their relatives. J Rheumatol 1997, 24:477-484.
13. Reimer G., Scheer U., Peters J.M., Tan E.M. Immunolocalization and partial characterization of a nucleolar autoantigen (PM-Scl) associated with polymyositis/scleroderma overlap syndromes. J Immunol 1986, 137:3802-3808.
14. Gelpi C., Algueró A., Angeles Martinez M., Vidal S., Juarez C., Rodriguez-Sanchez J.L. Identification of protein components reactive with anti-PM/Scl autoantibodies. Clin Exp Immunol 1990, 81:59-64.
15. Ho K.T., Reveille J.D. The clinical relevance of autoantibodies in scleroderma. Arthritis Res Ther 2003, 5:80-93.
16. Mahler M., Raijmakers R., Dähnrich C., Blüthner M., Fritzler M.J. Clinical evaluation of autoantibodies to a novel PM/Scl peptide antigen. Arthritis Res Ther 2005, 7:R704-R713.
17. Fleiss J.L. Statistical methods for rates and proportions 1981, John Wiley, New York. second ed.
18. Bland J.M., Altman D.G. Statistics notes: Crohnbach's alpha. BMJ 1997, 314:572.
19. Gaudin C., Fortenfant F., Adoue D., Beyne-Rauzy O. Anti PM-Scl antibodies. Study of prevalence and of meaning. Rev Méd Interne 2006, 27:665-670.
20. Hausmanowa-Petrusewicz I., Kowalska-Oledzka E., Miller F.W., Jarzabek-Chorzelska M., Targoff I.N., Blaszczyk-Kostanecka M., et al. Clinical, serologic, and immunogenetic features in Polish patients with idiopathic inflammatory myopathies. Arthritis Rheum 1997, 40:1257-1266.
21. Koenig M., Fritzler M.J., Targoff I.N., Troyanov Y., Senécal J.L. Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomes. Arthritis Res Ther 2007, 9:R78.
22. Yamasaki Y., Honkanen-Scott M., Hernandez L., Ikeda K., Barker T., Bubb M.R., et al. Nucleolar staining cannot be used as a screening test for the scleroderma marker anti-RNA polymerase I/III antibodies. Arthritis Rheum 2006, 54:3051-3056.
23. Schnitz W., Taylor-Albert E., Targoff I.N., Reichlin M., Scofield R.H. Anti-PM/Scl autoantibodies in patients without clinical polymyositis or scleroderma. J Rheumatol 1996, 23:1729-1733.
24. Arbuckle M.R., McClain M.T., Rubertone M.V., Scofield R.H., Dennis G.J., James J.A., et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 2003, 349:1526-1533.
25. Ghirardello A., Rampudda M., Ekholm L., Bassi N., Tarricone E., Zampieri S., et al. Diagnostic performance and validation of autoantibody testing in myositis by a commercial line blot assay. Rheumatol Oxf 2010, 49:2370-2374.