Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues

Journal of Endocrinology

Volumn 221, Issue 3, 2014, Pages 415-427

  Padron, Alvaro Souto ^a   Neto, Ruy Andrade Louzada ^a   Pantaleão, Thiago Urgal ^a   De Souza Dos Santos, Maria Carolina ^a   Araujo, Renata Lopes ^a   De Andrade, Bruno Moulin ^a   Da Silva Leandro, Monique ^a   De Castro, João Pedro Saar Werneck ^a   Ferreira, Andrea Claudia Freitas ^a   De Carvalho, Denise Pires ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

3,5 T2; Deiodinase; Thyroid hormone metabolism; TSH

Indexed keywords

DIIODOTHYRONINE; HYDROGEN PEROXIDE; INSULIN; LIOTHYRONINE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; THYROID PEROXIDASE; THYROID TYPE 1 IODOTHYRONINE DEIODINASE; THYROID TYPE 2 IODOTHYRONINE DEIODINASE; THYROTROPIN; THYROTROPIN RECEPTOR; THYROXINE; THYROXINE DEIODINASE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ADULT; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL METABOLIC RATE; BODY MASS; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; ENERGY EXPENDITURE; ENZYME ACTIVITY; FAT MASS; GLUCOSE TOLERANCE; HYPOPHYSIS; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; HYPOTHYROIDISM; INSULIN BLOOD LEVEL; LEAN BODY WEIGHT; LIOTHYRONINE BLOOD LEVEL; MALE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESTING METABOLIC RATE; RETROPERITONEAL FAT; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TREATMENT DURATION; WEIGHT GAIN;

3,5-T2; DEIODINASE; THYROID HORMONE METABOLISM; TSH;

ANIMALS; BASAL METABOLISM; DIIODOTHYRONINES; FLAVOPROTEINS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHYROIDISM; IMMUNOBLOTTING; IODIDE PEROXIDASE; IODIDES; KIDNEY; LIVER; MALE; NADPH OXIDASE; OXYGEN CONSUMPTION; RATS; RATS, WISTAR; RECEPTORS, THYROTROPIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THYROID GLAND; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

EID: 84901627097     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-13-0502     Document Type: Article

References (51)

1. Antonelli A, Fallahi P, Ferrari SM, DiDomenicantonio A, Moreno M, Lanni A & Goglia F 2011 3,5-diiodo-L-thyronine increases resting metabolic rate and reduces body weight without undesirable side effects. Journal of Biological Regulators and Homeostatic Agents 25 655-660.
2. Araujo RL, Andrade BM, Figueiredo AS, Silva ML, Marassi MP, Pereira VS, Bouskela E & Carvalho DP 2008 Low replacement doses of thyroxine during food restriction restores type 1 deiodinase activity in rats and promotes body protein loss. Journal of Endocrinology 198 119-125. (doi:10.1677/JOE-08-0125)
3. Arnold S, Goglia F & Kadenbach B 1998 3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by ATP. European Journal of Biochemistry 252 325-330. (doi:10.1046/j.1432-1327.1998.2520325.x)
4. Ball SG, Sokolov J & Chin WW 1997 3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro. Journal of Molecular Endocrinology 19 137-147. (doi:10.1677/jme.0.0190137)
5. Baur A, Bauer K, Jarry H & Köhrle J 1997 3,5-diiodo-L-thyronine stimulates type 1 50deiodinase activity in rat anterior pituitaries in vivo and in reaggregate cultures and GH3 cells in vitro. Endocrinology 138 3242-3248. (doi:10.1210/endo.138.8.5333)
6. Berry MJ, Kieffer JD, Harnet JW & Larsen PR 1991 Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase. Journal of Biological Chemistry 266 14155-14158.
7. Blennemann B, Moon YK & Freake HC 1992 Tissue-specific regulation of fatty acid synthesis by thyroid hormone. Endocrinology 130 637-643. (doi:10.1210/endo.130.2.1733712)
8. Bradford MM 1976 A rapid and sensitive method for the quantification of microgram quantitties of protein utilizing the principle of protein dye binding. Analytical Biochemistry 72 248-254. (doi:10.1016/0003-2697(76)90527-3)
9. Carvalho DP & Ferreira AC 2007 The importance of sodium/iodide symporter (NIS) for thyroid cancer management. Arquivos Brasileiros de Endocrinologia e Metabologia 51 672-682. (doi:10.1590/S0004-27302007000500004)
10. Carvalho DP, Rego KGM & Rosenthal D 1994 Thyroid peroxidase in dyshormonogenetic goiters with organification and thyroglobulin defects. Thyroid 4 421-426. (doi:10.1089/thy.1994.4.421)
11. Chu Y, Huddleston GG, Clancy AN, Harris RB & Bartness TJ 2010 Epididymal fat is necessary for spermatogenesis, but not testosterone production or copulatory behavior. Endocrinology 151 5669-5679. (doi:10.1210/en.2010-0772)
12. Cimmino M, Mion F, Goglia F, Minaire Y & Géloën A 1996 Demonstration of in vivo metabolic effects of 3,5-di-iodothyronine. Journal of Endocrinology 149 319-325. (doi:10.1677/joe.0.1490319)
13. Dai G, Levy O & Carrasco N 1996 Cloning and characterization of the thyroid iodide transporter. Nature 379 485-460. (doi:10.1038/ 379458a0)
14. Engler D & Burger AG 1984 The deiodination of the iodothyronines and of their derivatives in man. Endocrine Reviews 5 151-184. (doi:10.1210/ edrv-5-2-151)
15. Engler D, Merkelbach U, Steiger G & Burger AG 1984 The monodeiodination of triiodothyronine and reverse triiodothyronine in man:a quantitative evaluation of the pathway by the use of turnover rate techniques. Journal of Clinical Endocrinology and Metabolism 58 49-61. (doi:10.1210/jcem-58-1-49)
16. Ferreira ACF, Lima LP, Araújo RL, Müller G, Rocha RP, Rosenthal D & Carvalho DP 2005 Rapid regulation of the thyroid sodium-iodide symporter (NIS) activity by thyrotropin, iodine and fasting. Journal of Endocrinology 184 69-76. (doi:10.1677/joe.1.05643)
17. Fortunato RS, Ignácio DL, Padron AS, Peçanha R, Marassi MP, Rosenthal D, Werneck-de-Castro JPS & Carvalho DP 2008 The effect of acute exercise session on thyroid hormone economy in rats. Journal of Endocrinology 198 347-353. (doi:10.1677/JOE-08-0174)
18. García-G C, López-Bojorquez L, Nuñez J, Valverde-R C & Orozco A 2007 3,5-Diiodothyronine in vivo maintains euthyroidal expression of type 2 iodothyronine deiodinase, growth hormone, and thyroid hormone receptor b1 in the killifish. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 293 R877-R883. (doi:10.1152/ ajpregu.00101.2007)
19. Gereben B, Goncalves C, Harney JW, Larsen PR & Bianco AC 2000 Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. Molecular Endocrinology 14 1697-1708. (doi:10.1210/mend.14.11.0558)
20. Gereben B, Zavacki AM, Ribich S, Kim BW, Huang SA, Simonides WS, Zeöld A & Bianco AC 2008 Cellular and molecular basis of deiodinaseregulated thyroid hormone signaling. Endocrine Reviews 29 898-938. (doi:10.1210/er.2008-0019)
21. Goglia F, Lanni A, Barth J & Kadenbach B 1994 Interaction of diiodothyronines with isolated cytochrome c oxidase. FEBS Letters 346 295-298. (doi:10.1016/0014-5793(94)00476-5)
22. Horst C, Rokos H & Seitz HJ 1989 Rapid stimulation of hepatic oxygen consumption by 3,5-di-iodo-L-thyronine. Biochemical Journal 261 945-950.
23. Horst C, Harneit A, Seitz HJ & Rokos H 1995 3,5-Di-iodo-L-thyronine suppresses TSH in rats in vivo and in rat pituitary fragments in vitro. Journal of Endocrinology 145 291-297. (doi:10.1677/joe.0.1450291)
24. Ikuyama S, Ohe K, Takayanagi R, Kohn LD & Nawata H 1997 Cloning and characterization of the 4.2 kb region of the rat thyrotropin receptor promoter. Endocrine Journal 44 247-256. (doi:10.1507/endocrj.44.247)
25. Koenig RJ 2005 Regulation of type 1 iodothyronine deiodinase in health and disease. Thyroid 15 835-840. (doi:10.1089/thy.2005.15.835)
26. Kopp P 2013 Thyroid hormone synthesis. In Werner and Ingbar's the Thyroid: a Fundamental and Clinical Text, 10th edn, pp 48-74. Eds LE Braverman & D Cooper10th edn. Philadelphia: Lippincottt Williams and Wilkins.
27. Kvetny J 1992 3,5-T2 stimulates oxygen consumption, but not glucose uptake in human mononuclear blood cells. Hormone and Metabolic Research 24 322-325. (doi:10.1055/s-2007-1003323)
28. de Lange P, Cioffi F, Senese R, Moreno M, Lombardi A, Silvestri E, De Matteis R, Lionetti L, Mollica MP, Goglia F et al. 2011 Nonthyrotoxic prevention of diet-induced insulin resistance by 3,5-diiodo-L-thyronine in rats. Diabetes 60 2730-2739. (doi:10.2337/db11-0207)
29. Lanni A, Moreno M, Cioffi M & Goglia F 1992 Effect of 3,30-diiodothyronine and 3,5-diiodothyronine on rat liver oxidative capacity. Molecular and Cellular Endocrinology 86 143-148. (doi:10.1016/ 0303-7207(92)90138-V)
30. Lanni A, Moreno M, Cioffi M & Goglia F 1993 Effect of 3,30-diiodothyronine and 3,5-di-iodothyronine on rat liver mitochondria. Journal of Endocrinology 136 59-64. (doi:10.1677/joe.0.1360059)
31. Lanni A, Moreno M, Lombardi A & Goglia F 1996 Calorigenic effect of diiodothyronines in the rat. Journal of Physiology 494 831-837.
32. Lanni A, Moreno M, Lombardi A, de Lange P, Silvestri E, Ragni M, Farina P, Baccari GC, Fallahi P, Antonelli A et al. 2005 3,5-diiodo-L-thyronine powerfully reduces adiposity in rats by increasing the burning of fats. FASEB Journal 19 1552-1554. (doi:10.1096/fj.05-3977fje)
33. Lombardi A, Beneduce L, Moreno M, Diano S, Colantuoni V, Ursini MV, Lanni A & Goglia F 2000 3,5-diiodo-L-thyronine regulates glucose-6-phosphate dehydrogenase activity in the rat. Endocrinology 141 1729-1734. (doi:10.1210/endo.141.5.7449)
34. Lombardi A, Lanni A, de Lange P, Silvestri E, Grasso P, Senese R, Goglia F & Moreno M 2007 Acute administration of 3,5-diiodo-L-thyronine to hypothyroid rats affects bioenergetic parameters in rat skeletal muscle mitochondria. FEBS Letters 581 5911-5916. (doi:10.1016/j.febslet. 2007.11.073)
35. Lombardi A, de Lange P, Silvestri E, Busiello RA, Lanni A, Goglia F & Moreno M 2009 3,5-Diiodo-L-thyronine rapidly enhances mitochondrial fatty acid oxidation rate and thermogenesis in rat skeletal muscle: AMP-activated protein kinase involvement. American Journal of Physiology. Endocrinology and Metabolism 296 E497-E502. (doi:10.1152/ajpendo.90642.2008)
36. Mangiullo R, Gnoni A, Damiano F, Siculella L, Zanotti F, Papa S & Gnoni GV 2010 3,5-diiodo-L-thyronine upregulates rat-liver mitochondrial F(o)F(1)-ATP synthase by GA-binding protein/nuclear respiratory factor-2. Biochimica et Biophysica Acta 1797 233-240. (doi:10.1016/j.bbabio.2009.10.009)
37. Mendoza A, Navarrete-Ramírez P, Hernández-Puga G, Villalobos P, Holzer G, Renaud JP, Laudet V & Orozco A 2013 3,5-T2 is an alternative ligand for the thyroid hormone receptor b1. Endocrinology 154 2948-2958. (doi:10.1210/en.2013-1030)
38. Milenkovic M, De Deken X, Jin L, De Felice M, Di Lauro R, Dumont JE, Corvilain B & Miot F 2007 Duox expressionandrelated H2O2 measurement inmouse thyroid: onset inembryonic developmentand regulationbyTSH in adult. Journal of Endocrinology 192 615-626. (doi:10.1677/JOE-06-0003)
39. Mollica MP, Lionetti L, Moreno M, Lombardi A, De Lange P, Antonelli A, Lanni A, Cavaliere G, Barletta A & Goglia F 2009 3,5-diiodo-Lthyronine, by modulating mitochondrial functions, reverses hepatic fat accumulation in rats fed a high-fat diet. Journal of Hepatology 51 363-370. (doi:10.1016/j.jhep.2009.03.023)
40. Moreno M, Lombardi A, Lombardi P, Goglia F & Lanni A 1998 Effect of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats. Life Sciences 62 2369-2377. (doi:10.1016/S0024-3205(98)00219-7)
41. Moreno M, Lombardi A, Beneduce L, Silvestri E, Pinna G, Goglia F & Lanni A 2002 Are the effects of T3 on resting metabolic rate in euthyroid rats entirely caused by T3 itself? Endocrinology 143 504-510. (doi:10.1210/endo.143.2.8613)
42. Moreno M, Silvestri E, De Matteis R, de Lange P, Lombardi A, Glinni D, Senese R, Cioffi F, Salzano AM, Scaloni A et al. 2011 3,5-Diiodo-Lthyronine prevents high-fat-diet-induced insulin resistance in rat skeletal muscle through metabolic and structural adaptations. FASEB Journal 25 3312-3324. (doi:10.1096/fj.11-181982)
43. Moura EG, Rosenthal D & Carvalho-Guimarães DP 1989 Thyroid peroxidase activity in human nodular goiters. Brazilian Journal of Medical and Biological Research 22 31-39.
44. Newby FD, DiGirolamo M, Cotsonis GA & Kutner MH 1990 Model of spontaneous obesity in aging male Wistar rats. American Journal of Physiology 259 R1117-R1125.
45. O'Reilly I & Murphy MP 1992 Studies on the rapid stimulation of mitochondrial respiration by thyroid hormones. Acta Endocrinologica 127 542-546. (doi:10.1530/acta.0.1270542)
46. Schmittgen TD, Lee EJ, Jiang J, Sarkar A, Yang L, Elton TS & Chen C 2008 Real-time PCR quantification of precursor and mature microRNA. Methods 44 31-38. (doi:10.1016/j.ymeth.2007.09.006)
47. Silvestri E, Cioffi F, Glinni D, Ceccarelli M, Lombardi A, de Lange P, Chambery A, Severino V, Lanni A, Goglia F et al. 2010 Pathways affected by 3,5-diiodo-L-thyronine in liver of high fat-fed rats: evidence from two-dimensional electrophoresis, blue-native PAGE, and mass spectrometry. Molecular BioSystems 6 2256-2271. (doi:10.1039/ c0mb00040j)
48. St Germain DL & Galton VA 1997 The deiodinase family of selenoproteins. Thyroid 7 655-668. (doi:10.1089/thy.1997.7.655)
49. Weyemi U, Caillou B, Talbot M, Ameziane-El-Hassani R, Lacroix L, Lagent-Chevallier O, Al Ghuzlan A, Roos D, Bidart JM, Virion A et al. 2010 Intracellular expression of reactive oxygen species-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues. Endocrine-Related Cancer 17 27-37. (doi:10.1677/ERC-09-0175)
50. Williams GR & Bassett JH 2011 Deiodinases: the balance of thyroid hormone: local control of thyroid hormone action: role of type 2 deiodinase. Journal of Endocrinology 209 261-272. (doi:10.1530/JOE-10-0448)
51. Yagil C, Barak A, Ben-Dor D, Rosenmann E, Bernheim J, Rosner M, Segev Y, Weksler-Zangen S, Raz I & Yagil Y 2005 Nonproteinuric diabetesassociated nephropathy in the Cohen rat model of type 2 diabetes. Diabetes 54 1487-1496. (doi:10.2337/diabetes.54.5.1487)