Age-related decline in DNA repair function explains diminished ovarian reserve, earlier menopause, and possible oocyte vulnerability to chemotherapy in women with BRCA mutations

Journal of Clinical Oncology

Volumn 32, Issue 10, 2014, Pages 1093-1094

  Oktay, Kutluk ^a   Moy, Fred ^a   Titus, Shiny ^a   Stobezki, Robert ^a   Turan, Volkan ^a   Dickler, Maura ^b   Goswami, Sumanta ^c  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c YESHIVA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BRCA1 PROTEIN; BRCA2 PROTEIN; TAMOXIFEN;

AMENORRHEA; CANCER CHEMOTHERAPY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENE MUTATION; HUMAN; LETTER; MENOPAUSE; OOCYTE; OVARIAN RESERVE; PRIORITY JOURNAL; BREAST TUMOR; FEMALE; GENETICS; MUTATION; NOTE; TUMOR SUPPRESSOR GENE;

AMENORRHEA; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; FEMALE; GENES, BRCA1; GENES, BRCA2; HUMANS; MUTATION;

EID: 84901598388     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2013.53.5369     Document Type: Letter

References (10)

1. Valentini A, Finch A, Lubinski J, et al: Chemotherapy-induced amenorrhea in patients with breast cancer with a BRCA1 or BRCA2 mutation. J Clin Oncol 31:3914-3919, 2013
2. Bines J, Oleske DM, Cobleigh MA: Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer. J Clin Oncol 14:1718-1729, 1996 (Pubitemid 26134232)
3. Sonmezer M, Oktay K: Fertility preservation in young women undergoing breast cancer therapy. Oncologist 11:422-434, 2006 (Pubitemid 43788268)
4. Rzepka-Górska I, Tarnowski B, Chudecka-Głaz A, et al: Premature menopause in patients with BRCA1 gene mutation. Breast Cancer Res Treat 100:59-63, 2006
5. Finch A, Valentini A, Greenblatt E, et al: Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation. Fertil Steril 99:1724-1728, 2013
6. Lin WT, Beattie M, Chen LM, et al: Comparison of age at natural menopause in BRCA1/2 mutation carriers with a non-clinic-based sample of women in northern California. Cancer 119:1652-1659, 2013
7. Oktay K, Kim JY, Barad D, et al: Association of BRCA1 mutations with occult primary ovarian insufficiency: A possible explanation for the link between infertility and breast/ovarian cancer risks. J Clin Oncol 28:240-244, 2010
8. Titus S, Li F, Stobezki R, et al: Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans. Sci Transl Med 5:172ra21, 2013
9. Pal T, Keefe D, Sun P, et al: Fertility in women with BRCA mutations: A case-control study. Fertil Steril 93:1805-1808, 2010
10. Soleimani R, Heytens E, Darzynkiewicz Z, et al: Mechanisms of chemotherapy-induced human ovarian aging: Double strand DNA breaks and microvascular compromise. Aging 3:782-793, 2011