Oligomannurarate sulfate inhibits CXCL12/SDF-1- Mediated proliferation and invasion of human tumor cells in vitro

Acta Pharmacologica Sinica

Volumn 34, Issue 12, 2013, Pages 1554-1559

  Wen, Wei Wei ^a   Xie, Shao ^a   Xin, Xian Liang ^a   Geng, Mei Yu ^a   Ding, Jian ^a   Chen, Yi ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Anticancer drug; Cancer; CXCL12 CXCR4 axis; JG6; Molecular docking; Oligomannurarate sulfate; Oligosaccharide; Surface plasmon resonance

Indexed keywords

ANTINEOPLASTIC AGENT; FOCAL ADHESION KINASE; JG 6; MITOGEN ACTIVATED PROTEIN KINASE; OLIGOSACCHARIDE; PAXILLIN; PROTEIN KINASE B; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; CXCL12 PROTEIN, HUMAN; MANNAN; OLIGOMANNURARATE SULFATE; TUMOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CERVICAL CANCER CELL LINE; CHEMICAL BOND; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; LIVER CANCER CELL LINE; MOLECULAR DOCKING; PROTEIN PHOSPHORYLATION; SURFACE PLASMON RESONANCE; TUMOR CELL; TUMOR GROWTH; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; LIVER TUMOR; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; TUMOR CELL LINE; TUMOR INVASION; UTERINE CERVIX TUMOR;

CELL LINE, TUMOR; CELL PROLIFERATION; CHEMOKINE CXCL12; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LIVER NEOPLASMS; MANNANS; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PHOSPHORYLATION; SURFACE PLASMON RESONANCE; UTERINE CERVICAL NEOPLASMS;

EID: 84901558374     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.83     Document Type: Article

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