Systemic cytokine levels show limited correlation with risk of HIV-1 acquisition

Journal of Acquired Immune Deficiency Syndromes

Volumn 66, Issue 2, 2014, Pages 135-139

  Lehman, Dara A ^a,b   Ronen, Keshet ^a   Blish, Catherine A ^c   Baeten, Jared M ^b   Jalalian Lechak, Zahra ^a   Jaoko, Walter ^d   Mandaliya, Kishorchandra ^e   Richardson, Barbra A ^a,b   McClelland, R Scott ^b,d   Overbaugh, Julie ^a  

^a USA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NAIROBI   (Kenya)

^e Department of Obstetrics and Gynaecology   (Kenya)

Author keywords

acquisition; cytokines; HIV; immune activation; susceptibility

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 7;

ADULT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOSTIMULATION; INFECTION RISK; INFECTION SENSITIVITY; INFLAMMATION; MAJOR CLINICAL STUDY; NONHUMAN; PRIORITY JOURNAL;

ADULT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CYTOKINES; DISEASE SUSCEPTIBILITY; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INTERLEUKIN-10; INTERLEUKIN-6; INTERLEUKIN-7; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84901499422     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0000000000000104     Document Type: Article

References (24)

1. Boily MC, Baggaley RF, Wang L, et al. Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies. Lancet Infect Dis. 2009;9:118-129.
2. Powers KA, Poole C, Pettifor AE, et al. Rethinking the heterosexual infectivity of HIV-1: a systematic review and meta-analysis. Lancet Infect Dis. 2008;8:553-563.
3. Miyazawa M, Lopalco L, Mazzotta F, et al. The "immunologic advantage" of HIV-exposed seronegative individuals. AIDS. 2009;23:161-175.
4. Iqbal SM, Kaul R. Mucosal innate immunity as a determinant of HIV susceptibility. Am J Reprod Immunol. 2008;59:44-54. (Pubitemid 350285582)
5. Mclaren PJ, Ball TB, Wachihi C, et al. HIV-Exposed seronegative commercial sex workers show a quiescent phenotype in the CD4 +T cell compartment and reduced expression of HIV-Dependent host factors. J Infect Dis. 2010;202:S339-S344.
6. Lajoie J, Juno J, Burgener A, et al. A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers. Mucosal Immunol. 2012;5:277-287.
7. Suy A, Castro P, Nomdedeu M, et al. Immunological profile of heterosexual highly HIV-exposed uninfected individuals: predominant role of CD4 and CD8 T-Cell activation. J Infect Dis. 2007;196:1191-1201. (Pubitemid 47580274)
8. Biasin M, Caputo SL, Speciale L, et al. Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women. J Infect Dis. 2000;182:1365-1374.
9. Naranbhai V, Karim SSA, Altfeld M, et al. Innate immune activation enhances HIV acquisition in women, diminishing the effectiveness of tenofovir microbicide gel. J Infect Dis. 2012;206:993-1001.
10. Lavreys L, Baeten JM, Kreiss JK, et al. Injectable contraceptive use and genital ulcer disease during the early phase of HIV-1 infection increase plasma virus load in women. J Infect Dis. 2004;189:303-311. (Pubitemid 38147255)
11. Martin HL, Nyange PM, Richardson BA, et al. Hormonal contraception, sexually transmitted diseases, and risk of heterosexual transmission of human immunodeficiency virus type 1. J Infect Dis. 1998;178: 1053-1059. (Pubitemid 28452198)
12. Defawe OD, Fong Y, Vasilyeva E, et al. Optimization and qualification of a multiplex bead array to assess cytokine and chemokine production by vaccine-specific cells. J Immunol Methods. 2012;382:117-128.
13. Roberts L, Passmore J-AS, Williamson C, et al. Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression. AIDS. 2010;24:819-831.
14. Simmons RP, Scully EP, Groden EE, et al. HIV-1 infection induces strong production of IP-10 through TLR7/9-dependent pathways. AIDS. 2013;27:2505-2517.
15. Liovat AS, Rey-Cuillé MA, Lecuroux C, et al. Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection. PLoS One. 2012;7:e46143.
16. Blish CA, McClelland RS, Richardson BA, et al. Genital inflammation predicts HIV-1 shedding independent of plasma viral load and systemic inflammation. J Acquir Immune Defic Syndr. 2012;61:436-440.
17. Keating SM, Golub ET, Nowicki M, et al. The effect of HIV infection and HAART on inflammatory biomarkers in a population-based cohort of women. AIDS. 2011;25:1823-1832.
18. Lajoie J, Poudrier J, Massinga Loembe M, et al. Chemokine expression patterns in the systemic and genital tract compartments are associated with HIV-1 infection in women from Benin. J Clin Immunol. 2009;30: 90-98.
19. Gumbi PP, Nkwanyana NN, Bere A, et al. Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV infection. J Virol. 2008;82:8529-8536.
20. Mitchell C, Hitti J, Paul K, et al. Cervicovaginal shedding of HIV type 1 is related to genital tract inflammation independent of changes in vaginal microbiota. AIDS Res Hum Retroviruses. 2011;27:35-39.
21. Jaspan HB, Liebenberg L, Hanekom W, et al. Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding. J Infect Dis. 2011;204:1550-1556.
22. Scott ME, Wilson SS, Cosentino LA, et al. Interlaboratory reproducibility of female genital tract cytokine measurements by luminex: implications for microbicide safety studies. Cytokine. 2011;56:430-434.
23. Wong H-L, Pfeiffer RM, Fears TR, et al. Reproducibility and correlations of multiplex cytokine levels in asymptomatic persons. Cancer Epidemiol Biomarkers Prev. 2008;17:3450-3456.
24. Djoba Siawaya JF, Roberts T, Babb C, et al. An evaluation of commercial fluorescent bead-based luminex cytokine assays. PLoS One. 2008;3:e2535.