Possible association between vitamin D deficiency and restless legs syndrome

Neuropsychiatric Disease and Treatment

Volumn 10, Issue , 2014, Pages 953-958

  Oran, Mustafa ^a   Unsal, Cuneyt ^a   Albayrak, Yakup ^a   Tulubas, Feti ^a   Oguz, Keriman ^a   Avci, Okan ^a   Turgut, Nilda ^a   Alp, Recep ^a   Gurel, Ahmet ^a  

^a NAMIK KEMAL UNIVERSITY   (Turkey)

Author keywords

25 hydroxyvitamin D; Dopamine; Dysfunction

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE; CALCIUM; FERRITIN; PHOSPHATE;

ADULT; AGE DISTRIBUTION; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BODY MASS; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PHOSPHATE BLOOD LEVEL; RESTLESS LEGS SYNDROME; SCORING SYSTEM; SEX RATIO; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

EID: 84901476094     PISSN: 11766328     EISSN: 11782021     Source Type: Journal    
DOI: 10.2147/NDT.S63599     Document Type: Article

References (35)

1. Innes KE, Selfe TK, Agarwal P. Restless legs syndrome and conditions associated with metabolic dysregulation, sympathoadrenal dysfunction, and cardiovascular disease risk: a systematic review. Sleep Med Rev. 2012;16(4):309-339.
2. Yeh P, Walters AS, Tsuang JW. Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment. Sleep Breath. 2012;16(4):987-1007.
3. Innes KE, Selfe TK, Agarwal P. Prevalence of restless legs syndrome in North American and Western European populations: a systematic review. Sleep Med. 2011;12(7):623-634.
4. Kushida CA. Clinical presentation, diagnosis, and quality of life issues in restless legs syndrome. Am J Med. 2007;120(1Suppl 1):S4-S12.
5. Nagandla K, De S. Restless legs syndrome: pathophysiology and modern management. Postgrad Med J. 2013;89(1053):402-410.
6. Zintzaras E, Kitsios GD, Papathanasiou AA, et al. Randomized trials of dopamine agonists in restless legs syndrome: a systematic review, quality assessment, and meta-analysis. Clin Ther. 2010;32(2):221-237.
7. Winkelman JW. Considering the causes of RLS. Eur J Neurol. 2006;13 Suppl 3:S8-S14.
8. Snyder AM, Connor JR. Iron, the substantia nigra and related neurological disorders. Biochim Biophys Acta. 2009;1790(7):606-614.
9. Allen RP, Barker PB, Wehrl F, Song HK, Earley CJ. MRI measurement of brain iron in patients with restless legs syndrome. Neurology. 2001;56(2):263-265.
10. Wrzosek M, Lukaszkiewicz J, Wrzosek M, et al. Vitamin D and the central nervous system. Pharmacol Rep. 2013;65(2):271-278.
11. Shinpo K, Kikuchi S, Sasaki H, Moriwaka F, Tashiro K. Effect of 1,25-dihydroxyvitamin D(3) on cultured mesencephalic dopaminergic neurons to the combined toxicity caused by L-buthionine sulfoximine and 1-methyl-4-phenylpyridine. J Neurosci Res. 2000;62(3):374-382.
12. Nakamura K, Wang W, Kang UJ. The role of glutathione in dopaminergic neuronal survival. J Neurochem. 1997;69(5):1850-1858.
13. Gómez Alonso C, Naves Díaz M, Rodríguez García M, Fernández Martín JL, Cannata Andía JB. [Review of the concept of vitamin D "sufficiency and insufficiency"]. Nefrologia. 2003;23Suppl 2:S73-S77. Spanish.
14. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J; Restless Legs Syndrome Diagnosis and Epidemiology workshop at the National Institutes of Health; International Restless Legs Syndrome Study Group. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4(2):101-119.
15. Sethi KD, Mehta SH. A clinical primer on restless legs syndrome: what we know, and what we don't know. Am J Manag Care. 2012; 18(5Suppl):S83-S88.
16. Connor JR, Boyer PJ, Menzies SL, et al. Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology. 2003;61(3):304-309.
17. Rios Romenets S, Postuma RB. Treatment of restless legs syndrome. Curr Treat Options Neurol. 2013;15(4):396-409.
18. Rizzo G, Tonon C, Manners D, Testa C, Lodi R. Imaging brain functional and metabolic changes in restless legs syndrome. Curr Neurol Neurosci Rep. 2013;13(9):372.
19. Michaud M, Soucy JP, Chabli A, Lavigne G, Montplaisir J. SPECT imaging of striatal pre-and postsynaptic dopaminergic status in restless legs syndrome with periodic leg movements in sleep. J Neurol. 2002;249(2):164-170.
20. Turjanski N, Lees AJ, Brooks DJ. Striatal dopaminergic function in restless legs syndrome: 18F-dopa and 11C-raclopride PET studies. Neurology. 1999;52(5):932-937.
21. Ruottinen HM, Partinen M, Hublin C, et al. An FDOPA PET study in patients with periodic limb movement disorder and restless legs syndrome. Neurology. 2000;54(2):502-504.
22. Connor JR, Wang XS, Allen RP, et al. Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome. Brain. 2009;132(Pt 9):2403-2412.
23. Evers S, Stögbauer F. Genetic association of Huntington's disease and restless legs syndrome? A family report. Mov Disord. 2003;18(2): 225-227.
24. Ondo WG, Lai D. Association between restless legs syndrome and essential tremor. Mov Disord. 2006;21(4):515-518.
25. Lespérance P, Djerroud N, Diaz Anzaldua A, Rouleau GA, Chouinard S, Richer F; Montréal Tourette Study Group. Restless legs in Tourette syndrome. Mov Disord. 2004;19(9):1084-1087.
26. Allen RP, Earley CJ. The role of iron in restless legs syndrome. Mov Disord. 2007;22Suppl 18:S440-S448.
27. Sun ER, Chen CA, Ho G, Earley CJ, Allen RP. Iron and the restless legs syndrome. Sleep. 1998;21(4):371-377.
28. O'Keeffe ST, Noel J, Lavan JN. Restless legs syndrome in the elderly. Postgrad Med J. 1993;69(815):701-703.
29. Rizzo G, Manners D, Testa C, et al. Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging. Mov Disord. 2013;28(13):1886-1890.
30. Lozoff B. Early iron deficiency has brain and behavior effects consistent with dopaminergic dysfunction. J Nutr. 2011;141(4):740-746.
31. Jellen LC, Lu L, Wang X, et al. Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice. Neuroscience. 2013;252:13-23.
32. Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F, Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrinol Metab. 2002;13(3):100-105.
33. Garcion E, Sindji L, Leblondel G, Brachet P, Darcy F. 1,25-dihydroxyvitamin D3regulates the synthesis of gamma-glutamyl transpeptidase and glutathione levels in rat primary astrocytes. J Neurochem. 1999;73(2):859-866.
34. Orme RP, Bhangal MS, Fricker RA. Calcitriol imparts neuroprotection in vitro to midbrain dopaminergic neurons by upregulating GDNF expression. PLoS One. 2013;8(4):e62040.
35. Balaban H, Yi{dotless}ldi{dotless}z ÖK, Çil G, et al. Serum 25-hydroxyvitamin D levels in restless legs syndrome patients. Sleep Med. 2012;13(7):953-957.