Substituted 3-acyl-2-phenylamino-1,4-naphthoquinones intercalate into DNA and cause genotoxicity through the increased generation of reactive oxygen species culminating in cell death

Molecular Medicine Reports

Volumn 10, Issue 1, 2014, Pages 405-410

  Farias, Mirelle Sifroni ^a   Pich, Claus Tröger ^a   Kviecinski, Maicon Roberto ^a   Bucker, Nádia Cristina Falcão ^a   Felipe, Karina Bettega ^a   Da Silva, Fabiana Ourique ^a   Günther, Tânia Mara Fisher ^a   Correia, João Francisco ^a   Ríos, David ^b   Benites, Julio ^b   Valderrama, Jaime A ^b,c   Buc Calderon, Pedro ^b,d   Pedrosa, Rozangela Curi ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b UNIVERSIDAD ARTURO PRAT   (Chile)

^c PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^d UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

3 acyl 2 phenylamino 1,4 naphthoquinones; Antitumor effect; Apoptosis; Cytotoxicity; DNA fragmentation; Reactive oxygen species generation

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; DNA; ETHIDIUM BROMIDE; INTERCALATING AGENT; PLASMID DNA; REACTIVE OXYGEN METABOLITE; SUBSTITUTED 3 ACYL 2 PHENYLAMINO 1,4 NAPHTHOQUINONE DERIVATIVE; UNCLASSIFIED DRUG; 2-PHENYLAMINO-1,4-NAPHTHOQUINONE; ANTINEOPLASTIC AGENT; NAPHTHOQUINONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASSAY; BREAST CANCER CELL LINE; CANCER CELL; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA FRAGMENTATION; EHRLICH ASCITES TUMOR; FLUORESCENCE; GENOTOXICITY; HUMAN; HUMAN CELL; MALE; MCF 7 CELL LINE; MOUSE; NONHUMAN; OXIDATION REDUCTION POTENTIAL; ANIMAL; BAGG ALBINO MOUSE; CARCINOMA, EHRLICH TUMOR; CHEMISTRY; DRUG EFFECTS; METABOLISM; TOXICITY; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, EHRLICH TUMOR; DNA; DNA DAMAGE; HUMANS; INTERCALATING AGENTS; MALE; MCF-7 CELLS; MICE; MICE, INBRED BALB C; NAPHTHOQUINONES; REACTIVE OXYGEN SPECIES; TRANSPLANTATION, HETEROLOGOUS;

EID: 84901463539     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2160     Document Type: Article

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