A novel trafficking-defective HCN4 mutation is associated with early-onset atrial fibrillation

Heart Rhythm

Volumn 11, Issue 6, 2014, Pages 1055-1062

  Macri, Vincenzo ^a,b   Mahida, Saagar N ^a,b   Zhang, Michael L ^a   Sinner, Moritz F ^a,c,d   Dolmatova, Elena V ^a,b   Tucker, Nathan R ^a,b   McLellan, Micheal ^a   Shea, Marisa A ^a   Milan, David J ^a,b   Lunetta, Kathryn L ^d,e   Benjamin, Emelia J ^d,e,f   Ellinor, Patrick T ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d FRAMINGHAM HEART STUDY   (United States)

^e BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atrial fibrillation; Electrophysiology; HCN4; Mutation

Indexed keywords

HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 4; UNCLASSIFIED DRUG; PROLINE; SERINE;

ADULT; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; GENE MUTATION; GENETIC SUSCEPTIBILITY; HEART ATRIUM FIBRILLATION; HUMAN; IMMUNOCYTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; SITE DIRECTED MUTAGENESIS; WILD TYPE; ANIMAL; ATRIAL FIBRILLATION; CHO CELL LINE; CRICETULUS; GENETICS; HAPLOINSUFFICIENCY; HEART FUNCTION TEST; METABOLISM; MIDDLE AGED; ONSET AGE; AMINO TERMINAL SEQUENCE; ARRHYTHMOGENESIS; CELL MIGRATION; CLINICAL FEATURE; ELECTROPHYSIOLOGICAL PROCEDURES; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENERAL HOSPITAL; GENETIC ASSOCIATION; GENETIC CODE; GENETIC RISK; GENETIC VARIABILITY; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 4 GENE; LOSS OF FUNCTION MUTATION; MOUSE; MUTATOR GENE; UNITED STATES;

AGE OF ONSET; ANIMALS; ATRIAL FIBRILLATION; CHO CELLS; CRICETULUS; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; FEMALE; HAPLOINSUFFICIENCY; HUMANS; HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; MUTAGENESIS, SITE-DIRECTED; PROTEIN TRANSPORT;

EID: 84901432903     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2014.03.002     Document Type: Article

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