Anti-fibrotic effects of specific-siRNA targeting of the receptor for advanced glycation end products in a rat model of experimental hepatic fibrosis

Molecular Medicine Reports

Volumn 10, Issue 1, 2014, Pages 306-314

  Cai, Xiao Gang ^a   Xia, Jin Rong ^a   Li, Wei Dong ^a   Lu, Feng Lin ^a   Liu, Juan ^a   Lu, Qin ^a   Zhi, Hong ^a  

^a SOUTHEAST UNIVERSITY   (China)

Author keywords

Hepatic fibrosis; Receptor for advanced glycation end products; Small interfering RNA

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA SMOOTH MUSCLE ACTIN; ANTIFIBROTIC AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; COLLAGEN TYPE 1; HYALURONIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LAMININ; MESSENGER RNA; PROCOLLAGEN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; CARBON TETRACHLORIDE; COLLAGEN TYPE 3; IMMUNOGLOBULIN RECEPTOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; EXPERIMENTAL LIVER FIBROSIS; EXPRESSION VECTOR; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE SILENCING; LIVER FUNCTION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; STELLATE CELL; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; ENZYMOLOGY; EXPERIMENTAL LIVER CIRRHOSIS; GENETICS; LIVER; METABOLISM; PATHOLOGY; RNA INTERFERENCE; SPRAGUE DAWLEY RAT; TOXICITY;

ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; CARBON TETRACHLORIDE; COLLAGEN TYPE III; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX; INTERLEUKIN-6; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, IMMUNOLOGIC; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84901426175     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2207     Document Type: Article

References (31)

1. Anthony PP, Ishak KG, Nayak NC, Poulsen HE, Scheuer PJ and Sobin LH: The morphology of cirrhosis. Recommendations on definition, nomenclature, and classification by a working group sponsored by the World Health Organization. J Clin Pathol 31: 395-414, 1978. (Pubitemid 8333033)
2. Friedman SL, Roll FJ, Boyles J and Bissell DM: Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci USA 82: 8681-8685, 1985. (Pubitemid 16101107)
3. Rippe RA: Life or death: the fate of the hepatic stellate cell following hepatic injury. Hepatology 27: 1447-1448, 1998.
4. Brandão DF, Ramalho LN, Ramalho FS, Zucoloto S, Martinelli Ade L and Silva Ode C: Liver cirrhosis and hepatic stellate cells. Acta Cir Bras 21 (Suppl 1): 54-57, 2006.
5. Lee UE and Friedman SL: Mechanisms of hepatic fibrogenesis. Best Pract Res Clin Gastroenterol 25: 195-206, 2011.
6. Neeper M, Schmidt AM, Brett J, et al: Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem 267: 14998-15004, 1992.
7. Sparvero LJ, Asafu-Adjei D, Kang R, et al: RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation. J Transl Med 7: 17, 2009.
8. Schmidt AM, Yan SD, Yan SF and Stern DM: The biology of the receptor for advanced glycation end products and its ligands. Biochim Biophys Acta 1498: 99-111, 2000.
9. Wautier MP, Chappey O, Corda S, Stern DM, Schmidt AM and Wautier JL: Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE. Am J Physiol Endocrinol Metab 280: E685-E694, 2001.
10. Mohamed AK, Bierhaus A, Schiekofer S, Tritschler H, Ziegler R and Nawroth PP: The role of oxidative stress and NF-kappaB activation in late diabetic complications. Biofactors 10: 157-167, 1999. (Pubitemid 29533824)
11. Fehrenbach H, Weiskirchen R, Kasper M and Gressner AM: Up-regulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts. Hepatology 34: 943-952, 2001. (Pubitemid 33032029)
12. Brett J, Schmidt AM, Yan SD, et al: Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues. Am J Pathol 143: 1699-1712, 1993. (Pubitemid 24058273)
13. Lohwasser C, Neureiter D, Popov Y, Bauer M and Schuppan D: Role of the receptor for advanced glycation end products in hepatic fibrosis. World J Gastroenterol 15: 5789-5798, 2009.
14. Guimarães EL, Empsen C, Geerts A and van Grunsven LA: Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells. J Hepatol 52: 389-397, 2010.
15. Xia JR, Liu NF and Zhu NX: Specific siRNA targeting the receptor for advanced glycation end products inhibits experimental hepatic fibrosis in rats. Int J Mol Sci 9: 638-661, 2008.
16. Barouch DH, Liu J, Li H, et al: Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys. Nature 482: 89-93, 2012.
17. Desmet VJ: Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kiernan TW and Wollman J. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis [Hepatology 1981;1:431-435]. J Hepatol 38: 382-386, 2003.
18. Ishak K, Baptista A, Bianchi L, et al: Histological grading and staging of chronic hepatitis. J Hepatol 22: 696-699, 1995.
19. Karin M and Lin A: NF-kappaB at the crossroads of life and death. Nat Immunol 3: 221-227, 2002.
20. Luo JL, Kamata H and Karin M: The anti-death machinery in IKK/NF-kappaB signaling. J Clin Immunol 25: 541-550, 2005.
21. Haskill S, Beg AA, Tompkins SM, et al: Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity. Cell 65: 1281-1289, 1991. (Pubitemid 121001340)
22. Beg AA, Finco TS, Nantermet PV and Baldwin AS Jr: Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation. Mol Cell Biol 13: 3301-3310, 1993. (Pubitemid 23157268)
23. Aggarwal BB: Nuclear factor-kappaB: the enemy within. Cancer Cell 6: 203-208, 2004.
24. Yan SD, Schmidt AM, Anderson GM, et al: Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J Biol Chem 269: 9889-9897, 1994. (Pubitemid 24196599)
25. Yan SD, Stern D and Schmidt AM: What's the RAGE? The receptor for advanced glycation end products (RAGE) and the dark side of glucose. Eur J Clin Invest 27: 179-181, 1997. (Pubitemid 27160246)
26. Li J and Schmidt AM: Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products. J Biol Chem 272: 16498-16506, 1997. (Pubitemid 27276477)
27. Hellerbrand C, Jobin C, Licato LL, Sartor RB and Brenner DA: Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells. Am J Physiol 275: G269-G278, 1998.
28. Hellerbrand, Wang SC, Tsukamoto H, Brenner DA and Rippe RA: Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Hepatology 24: 670-676, 1996.
29. Liu C, Tao Q, Sun M, et al: Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats. Lab Invest 90: 1805-1816, 2010.
30. Senoo H, Yoshikawa K, Morii M, Miura M, Imai K and Mezaki Y: Hepatic stellate cell (vitamin A-storing cell) and its relative - past, present and future. Cell Biol Int 34: 1247-1272, 2010.
31. Otogawa K, Ogawa T, Shiga R, Ikeda K and Kawada N: Induction of tropomyosin during hepatic stellate cell activation and the progression of liver fibrosis. Hepatol Int 3: 378-383, 2009.