Multilevel competing risk models to evaluate the risk of nosocomial infection

Critical Care

Volumn 18, Issue 2, 2014, Pages

  Wolkewitz, Martin ^a,b   Cooper, Ben S ^c   Palomar Martinez, Mercedes ^d   Alvarez Lerma, Francisco ^e   Olaechea Astigarraga, Pedro ^f   Barnett, Adrian G ^g   Harbarth, Stephan ^h   Schumacher, Martin ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c MAHIDOL UNIVERSITY   (Thailand)

^d HOSPITAL UNIVERSITARI ARNAU DE VILANOVA   (Spain)

^e Pediatric Intensive Care Unit Service   (Spain)

^f HOSPITAL DE GALDAKAO   (Spain)

^g QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^h GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; APACHE; ARTICLE; BACTEREMIA; CHILD; DEATH; DISEASE ASSOCIATION; ENVIRONMENTAL EXPOSURE; HOSPITAL DISCHARGE; HOSPITAL INFECTION; HOSPITAL READMISSION; HUMAN; INCIDENCE; INFANT; INFECTION RISK; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; NEWBORN; PRIORITY JOURNAL; PROBABILITY; RISK FACTOR; CLINICAL TRIAL; CROSS INFECTION; FEMALE; MALE; MIDDLE AGED; MULTICENTER STUDY; PRESCHOOL CHILD; THEORETICAL MODEL; TRENDS; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; CROSS INFECTION; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; MODELS, THEORETICAL; RISK FACTORS; YOUNG ADULT;

EID: 84901399579     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc13821     Document Type: Article

References (24)

1. Lambert ML, Suetens C, Savey A, Palomar M, Hiesmayr M, Morales I, Agodi A, Frank U, Mertens K, Schumacher M, Wolkewitz M. Clinical outcomes of health-care-associated infections and antimicrobial resistance in patients admitted to European intensive-care units: a cohort study. Lancet Infect Dis 2011, 11:30-38. 10.1016/S1473-3099(10)70258-9, 21126917.
2. Januel JM, Harbarth S, Allard R, Voirin N, Lepape A, Allaouchiche B, Guerin C, Lehot JJ, Robert MO, Fournier G, Jacques D, Chassard D, Gueugniaud PY, Artru F, Petit P, Robert D, Mohammedi I, Girard R, Cetre JC, Nicolle MC, Grando J, Fabry J, Vanhems P. Estimating attributable mortality due to nosocomial infections acquired in intensive care units. Infect Control Hosp Epidemiol 2010, 31(4):388-394. 10.1086/650754, 20156064.
3. Harbarth S, Sax H, Gastmeier P. The preventable proportion of nosocomial infections: an overview of published reports. J Hosp Infect 2003, 54(4):258-266. 10.1016/S0195-6701(03)00150-6, 12919755.
4. Roux AVD, Aiello AE. Multilevel analysis of infectious diseases. J Infect Dis 2005, 191(Supplement 1):S25-S33.
5. Vellinga A, Bennett K, Murphy AW, Cormican M. Principles of multilevel analysis and its relevance to studies of antimicrobial resistance. J Antimicrob Chemother 2012, 67(10):2316-2322. 10.1093/jac/dks237, 22729927.
6. Wolkewitz M, Vonberg R, Grundmann H, Beyersmann J, Gastmeier P, Bärwolff S, Geffers C, Behnke M, Rüden H, Schumacher M. Risk factors for the development of nosocomial pneumonia and mortality on intensive care units: application of competing risks models. Crit Care 2008, 12:R44. 10.1186/cc6852, 2447589, 18384672.
7. Schumacher M, Allignol A, Beyersmann J, Binder N, Wolkewitz M. Hospital-acquired infections: appropriate statistical treatment is urgently needed. Int J Epidemiol 2013, 42:1502-1508. 10.1093/ije/dyt111, 24038717.
8. Wolkewitz M, Harbarth S, Beyersmann J. Daily chlorhexidine bathing and hospital-acquired infection. N Engl J Med 2013, 368(24):2330.
9. Wolkewitz M, Di Termini S, Cooper B, Meerpohl J, Schumacher M. Paediatric hospital-acquired bacteraemia in developing countries. Lancet 2012, 379(9825):1484-1485.
10. Liquet B, Timsit JF, Rondeau V. Investigating hospital heterogeneity with a multi-state frailty model: application to nosocomial pneumonia disease in intensive care units. BMC Med Res Methodol 2012, 12:79. 10.1186/1471-2288-12-79, 3537543, 22702430.
11. Katsahian S, Boudreau C. Estimating and testing for center effects in competing risks. Stat Med 2011, 30(13):1608-1617. 10.1002/sim.4132, 21341296.
12. Spanish surveillance network HELICS-ENVIN. [http://hws.vhebron.net/envin-helics/].
13. Lopez-Pueyo M, Olaechea-Astigarraga P, Palomar-Martinez M, Insausti-Ordenana J, Alvarez-Lerma F, . ENVIN-HELICS Study Group Quality control of the surveillance programme of ICU-acquired infection (ENVIN-HELICS registry) in Spain. J Hosp Inf 2013, 84(2):126-31. ENVIN-HELICS Study Group.
14. Rondeau V, Commenges D, Joly P. Maximum penalized likelihood estimation in a gamma-frailty model. Lifetime Data Anal 2003, 9(2):139-153. 10.1023/A:1022978802021, 1961627, 12735493.
15. Andersen PK, Geskus RB, de Witte T, Putter H. Competing risks in epidemiology: possibilities and pitfalls. Int J Epidemiol 2012, 41(3):861-870. 10.1093/ije/dyr213, 3396320, 22253319.
16. Fine J, Gray RJ. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 1999, 94(446):496-509.
17. Rondeau V, Mazroui Y, Gonzalez JR. frailtypack: an R package for the analysis of correlated survival data with frailty models using penalized likelihood estimation or parametrical estimation. J Stat Softw 2012, 47(4):1-28.
18. Hansen S, Schwab F, Behnke M, Carsauw H, Heczko P, Klavs I, Lyytikainen O, Palomar M, Riesenfeld Orn I, Savey A, Szilagyi E, Valinteliene R, Fabry J, Gastmeier P. National influences on catheter-associated bloodstream infection rates: practices among national surveillance networks participating in the European HELICS project. J Hosp Infect 2009, 71:66-73. 10.1016/j.jhin.2008.07.014, 18799236.
19. Palomar M, Alvarez-Lerma F, Riera A, Diaz M, Torres F, Agra Y, Larizgoitia I, Goeschel C, Pronovost P. Impact of a national multimodal intervention to prevent catheter-related bloodstream infection in the ICU:the Spanish experience. Crit Care Med 2013, 41(10):2364-2372. 10.1097/CCM.0b013e3182923622, 23939352.
20. Wolkewitz M, Tacconelli E, Schumacher M. Aggressive versus conservative initiation of antibiotics. Lancet Infect Dis 2013, 13(5):387-388.
21. Aiken AM, Mturi N, Njuguna P, Mohammed S, Berkley JA, Mwangi I, Mwarumba S, Kitsao BS, Lowe BS, Morpeth SC, Hall AJ, Khandawalla I, Scott JA, Ahmed I, Akech S, Makazi AB, Hajj MB, Brent A, Chesaro C, Dayo H, Idro R, Kosgei P, Maitland K, Marsh K, Mwalekwa L, Mwaringa S, Newton C, Ngama M, Pamba A, Peshu N, et al. Risk and causes of paediatric hospital-acquired bacteraemia in K, ilifi District Hospital, Kenya: a prospective cohort study. Lancet 2011, 378(9808):2021-2027. 10.1016/S0140-6736(11)61622-X, 3242162, 22133536.
22. Latouche A, Allignol A, Beyersmann J, Labopin M, Fine JP. A competing risks analysis should report results on all cause-specific hazards and cumulative incidence functions. J Clin Epidemiol 2013, 66(6):648-653. 10.1016/j.jclinepi.2012.09.017, 23415868.
23. Cheng AC, Bass P, Scheinkestel C, Leong T. Public reporting of infection rates as quality indicators. Med J Aust 2011, 195(6):326-327. 10.5694/mja11.10778, 21929493.
24. Gastmeier P, Brauer H, Hauer T, Schumacher M, Daschner F, Ruden H. How many nosocomial infections are missed if identification is restricted to patients with either microbiology reports or antibiotic administration?. Infect Control Hosp Epidemiol 1999, 20(2):124-127. 10.1086/501600, 10064217.