Perioperative Management Issues of Direct Oral Anticoagulants

Seminars in Hematology

Volumn 51, Issue 2, 2014, Pages 112-120

  Kozek Langenecker, Sibylle A ^a  

^a Department of Anaesthetics and Intensive Care   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ANTIVITAMIN K; APIXABAN; DABIGATRAN; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; RIVAROXABAN; VITAMIN K GROUP;

ANTICOAGULANT THERAPY; ARTICLE; AWARENESS; BLEEDING; BLOOD CLOTTING TEST; BLOOD EXAMINATION; BLOOD TRANSFUSION; CHRONIC DRUG ADMINISTRATION; COMPRESSION THERAPY; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; ELECTIVE SURGERY; EMERGENCY SURGERY; HOSPITALIZATION; HUMAN; INTERNATIONAL NORMALIZED RATIO; MAJOR SURGERY; MINOR SURGERY; PARTIAL THROMBOPLASTIN TIME; PATIENT ASSESSMENT; PERIOPERATIVE PERIOD; PERSONALIZED MEDICINE; POSTOPERATIVE CARE; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE NAUSEA AND VOMITING; POSTOPERATIVE PAIN; POSTOPERATIVE THROMBOSIS; PREOPERATIVE CARE; PRESCRIPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REGIONAL ANESTHESIA; RISK ASSESSMENT; RISK FACTOR; THROMBIN TIME; THROMBOEMBOLISM; THROMBOSIS; THROMBOSIS PREVENTION;

ADMINISTRATION, ORAL; ALGORITHMS; ANTICOAGULANTS; HEMORRHAGE; HUMANS; INDIVIDUALIZED MEDICINE; POSTOPERATIVE COMPLICATIONS; PREOPERATIVE CARE; THROMBOSIS;

EID: 84901377094     PISSN: 00371963     EISSN: 15328686     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2014.02.001     Document Type: Article

References (40)

1. Fugate J.E., Rabinstein A.A., McBane R.D., Lanzino G. Dabigatran: a primer for neurosurgeons. World Neurosurg 2013, 79:154-158.
2. Guyatt G.H., Akl E.A., Crowther M., Gutterman D.D., Schuünemann H.J. American College of Chest Physicians Antithrombotic Therapy and Prevention of Thrombosis Panel. Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012, 141:7S-47S.
3. iPhone application: apple app store; search terms dabigatran and OEGARI (last access: January 13, 2014).
4. Kozek-Langenecker S., Afshari S., Albaladejo P., et al. Guidelines on the management of severe perioperative bleeding. Eur J Anaesthesiol 2013, 30:270-382.
5. ; NOAC-line (last access: January 13, 2014). http://www.oegari.at.
6. Weltermann A., Brodmann M., Domanovits H., et al. Dabigatran in patients with atrial fibrillation: perioperative and periinterventional management. Wien Klin Wochenschr 2012, 124(9-10):340-347.
7. Fries D., Giurea A., Gütl M., et al. Management of dabigatran-induced bleeding: expert statement. Wien Klin Wochenschr 2013, 125:721-729.
8. Schaden E., Kozek-Langenecker S.A. Direct thrombin inhibitors (review). Intensive Care Med 2010, 36:1127-1137.
9. Samama C.M. New anticoagulants: pharmacology and clinical studies. Wien Med Wochenschr 2011, 161(3-4):54-57.
10. Ortel T.L. Perioperative management of patients on chronic antithrombotic therapy. Hematol Am Soc Hematol Educ Program 2012, 2012:529-535.
11. Halbmayer W.M., Weigel G., Quehenberger P., et al. Interference of the new oral anticoagulant dabigatran with frequently used coagulation tests. Clin Chem Lab Med 2012, 50:1601-1605.
12. Lindahl T.L., Baghaei F., Blixter I.F., et al. Expert Group on Coagulation of the External Quality Assurance in Laboratory Medicine in Sweden. Effects of the oral, direct thrombin inhibitor dabigatran on five common coagulation assays. Thromb Haemost 2011, 105:371-378.
13. Sauer H., Wankmüller H., Leschke M. Blutungsmanagement, perioperatives und periprozedurales Bridging: Vorschlag praktischer Strategien für die neuen oralen Antikoagulantien. Klinikarzt 2012, 41:26-32.
14. Goodnough L.T., Shander A. Special article: current status of pharmacologic therapies in. Anesth Analg 2013, 116:15-34.
15. Regionalanästhesie unter gerinnungshemmender Medikation. Empfehlungen der Arbeitsgruppe perioperative Gerinnung der ÖGARI. Accessed January 10, 2014. http://www.oegari.at.
16. Gogarten W., Vandermeulen E., Van Aken H., et al. Regional anaesthesia and antithrombotic agents: recommendations of the European Society of Anaesthesiology. Eur J Anaesthesiol 2010, 27:999-1015.
17. Horlocker T.T., Wedel D.J., Rowlingson J.C., et al. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine evidence-based guidelines (third edition). Reg Anesth Pain Med 2010, 35:64-101.
18. Valsami S., Asmis L. Brief reivew of 50 years of perioperative thrombosis and hemostasis management. Semin Hematol 2013, 50:79-87.
19. Rossaint R., Bouillon B., Cerny V., et al. Task Force for Advanced Bleeding Care in Trauma. Management of bleeding following major trauma: an updated European guideline. Crit Care 2010, 14:R52.
20. Fries D., Innerhofer P., Perger P., Gütl M., Hofmann N., Kneifel W., Neuner L., et al. Gerinnungsmanagement bei traumatisch bedingter Massivblutung. AINS 2010, 45:552-561.
21. Hébert P.C., Wells G., Blajchman M.A., et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999, 340:409-417.
22. Afshari A., Wikkelsø A., Brok J., Møller A.M., Wetterslev J. Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database Syst Rev 2011, 3. CD 007871.
23. Gerotziafas G.T., Chakroun T., Samama M.M., Elalamy I. In vitro comparison of the effect of fondaparinux and enoxaparin on whole blood tissue factor-triggered thromboelastography profile. Thromb Haemost 2004, 92:1296-1302.
24. Schaden E., Hörburger D., Hacker S., et al. Determination of enoxaparin with rotational thrombelastometry (ROTEM) using the prothrombinase-induced clotting time reagent (PiCT). Blood Coagul Fibrinolysis 2010, 21:256-261.
25. Schaden E., Schober A., Hacker S., Kozek-Langenecker S. Ecarin modified rotational thrombelastometry-a point-of-care applicable alternative to monitor the direct thrombin inhibitor argatroban. Wien Klin Wochenschr 2013, 125:156-159.
26. Pabinger I., Tiede A., Kalina U., et al. Impact of infusion speed on the safety and effectiveness of prothrombin complex concentrate: a prospective clinical trial of emergency anticoagulation reversal. Ann Hematol 2010, 89:309-316.
27. Baron T.H., Kamath P.S., McBane R.D. Management of anithrombotic therapy in patients undergoing invasive procedures. N Engl J Med 2013, 368:2113-2124.
28. van Ryn J., Litzenburger T., Waterman A., et al. Dabigatran anticoagulant activity is neutralized by an antibody selective to Dabigatran in in vitro and in vivo models. JACC 2011, 57:E1130. (abstract AHA 2011).
29. Cotton B.A., McCarthy J.J., Holcomb J.B. Acutely injured patients on dabigatran. N Engl J Med 2011, 365:2038-2040.
30. Weitz J.I., Quinlan D.J., Eikelboom J.W. Periprocedural management and approach to bleeding in patients taking dabigatran. Circulation 2012, 126:2428-2432.
31. Pezborn E., Trabandt A., Selbach K., Tinel H. Prothrombin complex concentrate reverses the effects of high-dose rivaroxaban in rats [Abstract]. Pathophysiol Haemost Thromb 2010, 37:A10-OC251.
32. van Ryn J., Stangier J., Haertter S., et al. Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost 2010, 103:1116-1127.
33. Eerenberg E.S. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate. Circulation 2011, 124:1573-1579.
34. Identifier: NCT01955720. http://www.CinicalTrials.gov.
35. Spannagl M., Bauersachs E., Debus E.S., et al. Therapie mit Dabigatran-Periinterventionelles Management und Interpretation von Gerinnungstests. Hämostaseologie 2012, 32:294-305.
36. Kozek-Langenecker S., Sorensen B., Hess J., Spahn D.R. Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review. Crit Care 2011, 15:R239.
37. Abdel-Wahab O., Healy B., Dzik W. Effect of fresh frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities. Transfusion 2006, 46:1279-1285.
38. Kozek-Langenecker S.A. New anticoagulants: perioperative considerations. Wien Med Wochenschr 2011, 161:63-67.
39. Pfanner G., Koscielny J., Pernerstorfer T., et al. Preoperative evaluation of the bleeding history. Recommendations of the working group on perioperative coagulation of the Austrian Society for Anaesthesia, Resuscitation and Intensive Care. Anaesthesist 2007, 56:604-611.
40. Smith I., Kranke P., Murat I., et al. Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol 2011, 28(8):556-569.