메뉴 건너뛰기




Volumn 2, Issue 6, 2014, Pages 617-623

Bendamustine in the treatment of chronic lymphocytic leukemia

Author keywords

Bendamustine; Chronic lymphocytic leukemia; Fludarabine; Rituximab; Small molecule kinase inhibitor

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ALEMTUZUMAB; BENDAMUSTINE; CHLORAMBUCIL; CORTICOSTEROID; CYCLOPHOSPHAMIDE; DUVELISIB; FLUDARABINE; IBRUTINIB; IDELALISIB; LENALIDOMIDE; MEDI 551; MONOCLONAL ANTIBODY; OBINUTUZUMAB; OFATUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PREDNISONE; PROTEIN TYROSINE KINASE INHIBITOR; RITUXIMAB; UNCLASSIFIED DRUG; VENETOCLAX;

EID: 84901353855     PISSN: None     EISSN: 21678707     Source Type: Journal    
DOI: 10.1517/21678707.2014.903173     Document Type: Article
Times cited : (3)

References (36)
  • 1
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with Bcell chronic lymphocytic leukemia: Results from cancer and leukemia group B 9712
    • Byrd JC, Peterson BL, Morrison VA, et al. Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with Bcell chronic lymphocytic leukemia: results from cancer and leukemia group B 9712. Blood 2003;101:6-14
    • (2003) Blood , vol.101 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3
  • 2
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
    • Keating MJ, O'Brien S, Albitar M, et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol 2005;23(18):4079-88
    • (2005) J Clin Oncol , vol.23 , Issue.18 , pp. 4079-4088
    • Keating, M.J.1    O'brien, S.2    Albitar, M.3
  • 3
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised open-label phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 2010;376(974 7):1164-74
    • (2010) Lancet , vol.376 , Issue.974-977 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 4
    • 63049113411 scopus 로고    scopus 로고
    • Bendamustine: Rebirth of an old drug
    • Cheson BD, Rummel MJ. Bendamustine: rebirth of an Old Drug. J Clin Oncol 2009;27(9):1492-501
    • (2009) J Clin Oncol , vol.27 , Issue.9 , pp. 1492-1501
    • Cheson, B.D.1    Rummel, M.J.2
  • 5
    • 40749085662 scopus 로고    scopus 로고
    • Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents
    • Leoni LM, Bailey B, Reifert J, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res 2008;14:309-17
    • (2008) Clin Cancer Res , vol.14 , pp. 309-317
    • Leoni, L.M.1    Bailey, B.2    Reifert, J.3
  • 7
    • 33947305075 scopus 로고    scopus 로고
    • Characterization of two phase i metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride
    • Teichert J, Baumann F, Chao Q, et al. Characterization of two phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride. Cancer Chemother Pharmacol 2007;59(6):759-70
    • (2007) Cancer Chemother Pharmacol , vol.59 , Issue.6 , pp. 759-770
    • Teichert, J.1    Baumann, F.2    Chao, Q.3
  • 8
    • 78149406113 scopus 로고    scopus 로고
    • Bendamustine pharmacokinetic profile and exposure-response relationships in patients (pts) with indolent NHL
    • Owen JS, Melhem M, Passarell JA, et al. Bendamustine pharmacokinetic profile and exposure-response relationships in patients (pts) with indolent NHL. Cancer Chemother Pharmacol 2010;66(6):1039-49
    • (2010) Cancer Chemother Pharmacol , vol.66 , Issue.6 , pp. 1039-1049
    • Owen, J.S.1    Melhem, M.2    Passarell, J.A.3
  • 9
    • 53049109651 scopus 로고    scopus 로고
    • Bendamustine for the treatment of relapsed indolent NHL
    • Weide R. Bendamustine for the treatment of relapsed indolent NHL. Ther Clin Risk Manag 2008;4(4):727-32
    • (2008) Ther Clin Risk Manag , vol.4 , Issue.4 , pp. 727-732
    • Weide, R.1
  • 10
    • 84877996682 scopus 로고    scopus 로고
    • Safe and effective treatment of aggressive non-hodgkin lymphoma with rituximab and bendamustine in patients with severe liver impairment
    • McCloskey JK, Broome CM, Cheson BD. Safe and effective treatment of aggressive non-hodgkin lymphoma with rituximab and bendamustine in patients with severe liver impairment. Clin Adv Hematol Oncol 2013;11(3):184-8
    • (2013) Clin Adv Hematol Oncol , vol.11 , Issue.3 , pp. 184-188
    • McCloskey, J.K.1    Broome, C.M.2    Cheson, B.D.3
  • 12
    • 0036337956 scopus 로고    scopus 로고
    • Bendamustine in the treatment of CLL: Results and future perspectives
    • Aivado M, Schulte K, Henze L, et al. Bendamustine in the treatment of CLL: results and future perspectives. Semin Oncol 2002;29:19-22
    • (2002) Semin Oncol , vol.29 , pp. 19-22
    • Aivado, M.1    Schulte, K.2    Henze, L.3
  • 13
    • 27144548424 scopus 로고    scopus 로고
    • Efficacy of bendamustine in patients with relapsed or refractory CLL
    • Bergmann MA, Goebeler ME, Herold M, et al. Efficacy of bendamustine in patients with relapsed or refractory CLL. Haematologica 2005;90:1357-64
    • (2005) Haematologica , vol.90 , pp. 1357-1364
    • Bergmann, M.A.1    Goebeler, M.E.2    Herold, M.3
  • 14
    • 28644433498 scopus 로고    scopus 로고
    • Phase-I/II study to evaluate dose limiting toxicity, maximum tolerated dose, and tolerability of bendamustine in pre-treated patients with B-lymphocytic leukaemia requiring therapy
    • Lissitchkov T, Arnaudov G, Peytchev D, et al. Phase-I/II study to evaluate dose limiting toxicity, maximum tolerated dose, and tolerability of bendamustine in pre-treated patients with B-lymphocytic leukaemia requiring therapy. J Cancer Res Clin Oncol 2006;132:99-104
    • (2006) J Cancer Res Clin Oncol , vol.132 , pp. 99-104
    • Lissitchkov, T.1    Arnaudov, G.2    Peytchev, D.3
  • 15
    • 0036449340 scopus 로고    scopus 로고
    • High rates of long-lasting remissions after 5-day bendamustine chemotherapy cycles in pretreated low-grade NHL
    • Bremer K. High rates of long-lasting remissions after 5-day bendamustine chemotherapy cycles in pretreated low-grade NHL. J Cancer Res Clin Oncol 2002;128:603-9
    • (2002) J Cancer Res Clin Oncol , vol.128 , pp. 603-609
    • Bremer, K.1
  • 16
    • 84877923389 scopus 로고    scopus 로고
    • Bendamustine compared to fludarabine as second-line treatment in chronic lymphocytic leukemia
    • Niederle N, Megdenberg D, Balleisen L, et al. Bendamustine compared to fludarabine as second-line treatment in chronic lymphocytic leukemia. Ann Hematol 2013;92(5):653-60
    • (2013) Ann Hematol , vol.92 , Issue.5 , pp. 653-660
    • Niederle, N.1    Megdenberg, D.2    Balleisen, L.3
  • 17
    • 84866314013 scopus 로고    scopus 로고
    • Bendamustine compared with chlorambucil in previously untreatedpatients with CLL
    • Knauf WU, Lissitchkov T, Aldaoud A, et al. Bendamustine compared with chlorambucil in previously untreatedpatients with CLL. Br J Haematol 2012;159(1):67-77
    • (2012) Br J Haematol , vol.159 , Issue.1 , pp. 67-77
    • Knauf, W.U.1    Lissitchkov, T.2    Aldaoud, A.3
  • 18
    • 80053020928 scopus 로고    scopus 로고
    • Bendamustine Combined with Rituximab in Patients with Relapsed and/or Refractory CLL
    • Fischer K, Cramer P, Busch R, et al. Bendamustine Combined With Rituximab in Patients With Relapsed and/or Refractory CLL. J Clin Oncol 2011;30(26):3559-66
    • (2011) J Clin Oncol , vol.30 , Issue.26 , pp. 3559-3566
    • Fischer, K.1    Cramer, P.2    Busch, R.3
  • 19
    • 84866531516 scopus 로고    scopus 로고
    • Bendamustine in Combination with Rituximab for Previously Untreated Patients with CLL
    • Fischer K, Cramer P, Busch R, et al. Bendamustine in Combination With Rituximab for Previously Untreated Patients With CLL. J Clin Oncol 2012;30(26):3209-16
    • (2012) J Clin Oncol , vol.30 , Issue.26 , pp. 3209-3216
    • Fischer, K.1    Cramer, P.2    Busch, R.3
  • 20
    • 84903201129 scopus 로고    scopus 로고
    • Chemoimmunotherapy with FCR versus BR in previously untreated and physically fit patients with advanced CLL: Results of a planned interim analysis of the CLL10 trial, an international, randomized study of GCLLSG
    • abstract
    • Eichhorst B, Fink A-M, Busch R, et al. Chemoimmunotherapy with FCR versus BR in previously untreated and physically fit patients with advanced CLL: results of a planned interim analysis of the CLL10 trial, an international, randomized study Of GCLLSG. Blood (ASH Annual Meetings) 2013;122:abstract 526
    • (2013) Blood (ASH Annual Meetings) , vol.122 , pp. 526
    • Eichhorst, B.1    Fink, A.-M.2    Busch, R.3
  • 21
    • 84895833178 scopus 로고    scopus 로고
    • Bendamustine in combination with ofatumumab in relapsed or refractory chronic lymphocytic leukemia: A GIMEMA multicenter phase II trial
    • Cortelezzi A, Sciumè M, Liberati AM, et al. Bendamustine in combination with ofatumumab in relapsed or refractory chronic lymphocytic leukemia: a GIMEMA multicenter phase II trial. Leukemia 2014;28(3):642-8
    • (2014) Leukemia , vol.28 , Issue.3 , pp. 642-648
    • Cortelezzi, A.1    Sciumè, M.2    Liberati, A.M.3
  • 22
    • 84926313933 scopus 로고    scopus 로고
    • Ofatumumab and bendamustine combination therapy in patients with untreated and relapsed chronic lymphocytic leukemia: Initial results of the phase II study OMB 115991
    • abstract 4.29
    • Offner F, Panagiotidis P, Afanasyev B, et al. Ofatumumab and bendamustine combination therapy in patients with untreated and relapsed chronic lymphocytic leukemia: initial results of the phase II study OMB 115991. 15th iwCLL 2013;abstract 4.29
    • (2013) 15th IwCLL
    • Offner, F.1    Panagiotidis, P.2    Afanasyev, B.3
  • 23
    • 84898414549 scopus 로고    scopus 로고
    • Head-to-head comparison of obinutuzumab (GA101) plus chlorambucil (Clb) versus rituximabplus Clb in patients with CLL and Co- existing medical conditions (Comorbidities): Final Stage 2 results of the CLL11 Trial
    • abstract 6
    • Goede V, Fischer K, Busch R, et al. Head-To-Head Comparison Of Obinutuzumab (GA101) Plus Chlorambucil (Clb) Versus RituximabPlus Clb In Patients With CLL and Co- Existing Medical Conditions (Comorbidities): final Stage 2 Results Of The CLL11 Trial. Blood (ASH Annual Meetings) 2013;122:abstract 6
    • (2013) Blood (ASH Annual Meetings) , vol.122
    • Goede, V.1    Fischer, K.2    Busch, R.3
  • 24
    • 84901370410 scopus 로고    scopus 로고
    • Bendamustine and Lenalidomide in Relapsed/Refractory CLL
    • abstract 4618
    • Ujjani C, Karim S, Goswami T, et al. Bendamustine and Lenalidomide in Relapsed/Refractory CLL. Blood (ASH Annual Meetings) 2011;118:abstract 4618
    • (2011) Blood (ASH Annual Meetings) , vol.118
    • Ujjani, C.1    Karim, S.2    Goswami, T.3
  • 25
    • 84901370301 scopus 로고    scopus 로고
    • Bendamustine and lenalidomide in relapsed/refractory lymphoid malignancies
    • abstract 8066
    • Cheson BD, Ujjani CS, Karim SM, et al. Bendamustine and lenalidomide in relapsed/refractory lymphoid malignancies. J Clin Oncol (ASCO Annual Meeting) 2011;29(15):abstract 8066
    • (2011) J Clin Oncol (ASCO Annual Meeting) , vol.29 , Issue.15
    • Cheson, B.D.1    Ujjani, C.S.2    Karim, S.M.3
  • 26
    • 84901322377 scopus 로고    scopus 로고
    • Bendamustine + rituximab chemoimmunotherapy and maintenance lenalidomide in relapsed/refractory CLL and small lymphocytic lymphoma
    • abstract 3647
    • Chang J, Zhang C, Kim K, et al. Bendamustine + rituximab chemoimmunotherapy and maintenance lenalidomide in relapsed/refractory CLL and small lymphocytic lymphoma. Blood (ASH Annual Meetings) 2012;120:abstract 3647
    • (2012) Blood (ASH Annual Meetings) , vol.120
    • Chang, J.1    Zhang, C.2    Kim, K.3
  • 27
    • 84881225049 scopus 로고    scopus 로고
    • Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma
    • Wang ML, Rule S, Martin P, et al. Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma. N Engl J Med 2013;369(6):507-16
    • (2013) N Engl J Med , vol.369 , Issue.6 , pp. 507-516
    • Wang, M.L.1    Rule, S.2    Martin, P.3
  • 28
    • 84879748062 scopus 로고    scopus 로고
    • Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
    • Byrd JC, Furman RR, Coutre SE, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med 2013;369(1):32-42
    • (2013) N Engl J Med , vol.369 , Issue.1 , pp. 32-42
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.E.3
  • 29
    • 84901334549 scopus 로고    scopus 로고
    • Single agent ibrutinib (PCI-32765) is highly effective in chronic lymphocytic leukemia patients with 17p deletion
    • abstract 008
    • Wiestner A, Farooqui M, Valdez J, et al. Single agent ibrutinib (PCI-32765) is highly effective in chronic lymphocytic leukemia patients with 17p deletion. 12th ICML 2013;abstract 008
    • (2013) 12th ICML
    • Wiestner, A.1    Farooqui, M.2    Valdez, J.3
  • 30
    • 84867843137 scopus 로고    scopus 로고
    • Combination of the BTK inhibitor PCI-32765 with BR in patients with relapsed/refractory CLL
    • abstract 6515
    • O'brien S, Barrientos J, Flinn I, et al. Combination of the BTK inhibitor PCI-32765 with BR in patients with relapsed/refractory CLL. J Clin Oncol (ASCO Annual Meetings) 2012;30(15):abstract 6515
    • (2012) J Clin Oncol (ASCO Annual Meetings) , vol.30 , Issue.15
    • O'brien, S.1    Barrientos, J.2    Flinn, I.3
  • 31
    • 80053079880 scopus 로고    scopus 로고
    • Phase i study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110d, in patients with previously treated chronic lymphocytic leukemia
    • abstract 6631
    • Coutre S, Byrd J, Furman R, et al. Phase I study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110d, in patients with previously treated chronic lymphocytic leukemia. J Clin Oncol (ASCO Annual Meetings) 2011;29(15):abstract 6631
    • (2011) J Clin Oncol (ASCO Annual Meetings) , vol.29 , Issue.15
    • Coutre, S.1    Byrd, J.2    Furman, R.3
  • 32
    • 84876805720 scopus 로고    scopus 로고
    • A Phase 1 Study of the Selective PI3K Inhibitor CAL-101 (GS-1101) in Combination with Rituximab and/or Bendamustine in Patients with Relapsed or Refractory CLL
    • abstract 1787
    • Sharman J, de Vos S, Leonard J, et al. A Phase 1 Study of the Selective PI3K Inhibitor, CAL-101 (GS-1101), in Combination with Rituximab and/or Bendamustine in Patients with Relapsed or Refractory CLL. Blood (ASH Annual Meetings) 2011;118:abstract 1787
    • (2011) Blood (ASH Annual Meetings) , vol.118
    • Sharman, J.1    De Vos, S.2    Leonard, J.3
  • 33
  • 34
    • 84891373281 scopus 로고    scopus 로고
    • Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: An open-label multicentre phase 1b/2 trial
    • O'Brien S, Furman R, Coutre S, et al. Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trial. Lancet Oncol 2014;15(1):48-58
    • (2014) Lancet Oncol , vol.15 , Issue.1 , pp. 48-58
    • O'brien, S.1    Furman, R.2    Coutre, S.3
  • 35
    • 84889096434 scopus 로고    scopus 로고
    • A phase II study of the selective phosphatidylinositol 3-kinase delta (PI3K {delta}) inhibitor idelalisib (GS-1101) in combination with rituximab (R) in treatment-naive patients (pts) >=65 years with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)
    • abstract 7005
    • O'Brien S, Lamanna N, Kipps T, et al. A phase II study of the selective phosphatidylinositol 3-kinase delta (PI3K {delta}) inhibitor idelalisib (GS-1101) in combination with rituximab (R) in treatment-naive patients (pts) >=65 years with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). J Clin Oncol (ASCO Annual Meetings) 2013;31(15):abstract 7005
    • (2013) J Clin Oncol (ASCO Annual Meetings) , vol.31 , Issue.15
    • O'brien, S.1    Lamanna, N.2    Kipps, T.3
  • 36
    • 84901291095 scopus 로고    scopus 로고
    • Updated results of a Phase i first-in-human study of the BCL-2 inhibitor ABT-199 (GDC-0199) patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL)
    • abstract 057
    • Seymour J, Davids M, Pagel J, et al. Updated results of a Phase I first-in-human study of the BCL-2 inhibitor ABT-199 (GDC-0199) in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL). 12th ICML 2013;abstract 057
    • (2013) 12th ICML
    • Seymour, J.1    Davids, M.2    Pagel, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.