Angina pectoris and myocardial ischemia in the absence of obstructive coronary artery disease: Practical considerations for diagnostic tests

JACC: Cardiovascular Interventions

Volumn 7, Issue 5, 2014, Pages 453-463

  Radico, Francesco ^a   Cicchitti, Vincenzo ^a   Zimarino, Marco ^a   De Caterina, Raffaele ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

angina; cardiac syndrome X; coronary microcirculation; coronary spasm; endothelial dysfunction; myocardial ischemia; normal coronary arteries

Indexed keywords

ANGINA PECTORIS; ANGIOGRAPHY; ARTICLE; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY OBSTRUCTION; DIAGNOSTIC TEST; FUNCTIONAL DISEASE; HEART MUSCLE ISCHEMIA; HUMAN; MICROCIRCULATION; PRIORITY JOURNAL; PROGNOSIS; ALGORITHM; ANGIOCARDIOGRAPHY; CLINICAL PATHWAY; HEART FUNCTION TEST; MICROVASCULAR ANGINA; MYOCARDIAL ISCHEMIA; PREDICTIVE VALUE; RISK ASSESSMENT; RISK FACTOR; ACUTE CORONARY SYNDROME; ARTERY STEAL SYNDROME; ATRIOVENTRICULAR BLOCK; BLOOD VESSEL TONE; BLOOD VESSEL WALL; CARDIOVASCULAR MAGNETIC RESONANCE; CEREBROVASCULAR ACCIDENT; CIRCADIAN RHYTHM; CORONARY ARTERY ANEURYSM; CORONARY ARTERY ANOMALY; CORONARY ARTERY CONSTRICTION; CORONARY ARTERY DISEASE; CORONARY ARTERY SPASM; DIAGNOSTIC ACCURACY; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; FRACTIONAL FLOW RESERVE; HEALTH CARE COST; HEART DEATH; METABOLIC DISORDER; MICROANGIOPATHY; MYOCARDIAL BRIDGING; NOCICEPTION; OUT OF HOSPITAL CARDIAC ARREST; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; QUALITY OF LIFE; RESISTANCE BLOOD VESSEL; ST SEGMENT ELEVATION; SYNDROME X; THORAX PAIN; TRANSTHORACIC ECHOCARDIOGRAPHY; VARIANT ANGINA PECTORIS; VASOMOTOR REFLEX;

ALGORITHMS; CORONARY ANGIOGRAPHY; CRITICAL PATHWAYS; HEART FUNCTION TESTS; HUMANS; MICROVASCULAR ANGINA; MYOCARDIAL ISCHEMIA; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RISK ASSESSMENT; RISK FACTORS;

ACETYLCHOLINE; ADENOSINE; ADENOSINE TRIPHOSPHATE; AMLODIPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; ERGOMETRINE; GADOLINIUM; GLYCERYL TRINITRATE; METHYLERGOMETRINE MALEATE; NICORANDIL; NITRIC ACID DERIVATIVE; NITRIC OXIDE; ORGANIC NITRATE; POTASSIUM CHANNEL; SEROTONIN AGONIST; VASODILATOR AGENT;

EID: 84901333315     PISSN: 19368798     EISSN: 18767605     Source Type: Journal    
DOI: 10.1016/j.jcin.2014.01.157     Document Type: Review

References (52)

1. K.L. Gould, and K. Lipscomb Effects of coronary stenoses on coronary flow reserve and resistance Am J Cardiol 34 1974 48 55
2. G. Montalescot, U. Sechtem, and S. Achenbach et al. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology Eur Heart J 34 2013 2949 3003
3. M. Zimarino, L. Cappelletti, and V. Venarucci et al. Age-dependence of risk factors for carotid stenosis: an observational study among candidates for coronary arteriography Atherosclerosis 159 2001 165 173
4. M.R. Patel, E.D. Peterson, and D. Dai et al. Low diagnostic yield of elective coronary angiography N Engl J Med 362 2010 886 895
5. L. Jespersen, A. Hvelplund, and S.Z. Abildstrom et al. Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events Eur Heart J 33 2012 734 744
6. P. Ong, A. Athanasiadis, G. Borgulya, H. Mahrholdt, J.C. Kaski, and U. Sechtem High prevalence of a pathological response to acetylcholine testing in patients with stable angina pectoris and unobstructed coronary arteries. The ACOVA Study (Abnormal COronary VAsomotion in patients with stable angina and unobstructed coronary arteries) J Am Coll Cardiol 59 2012 655 662
7. T.P. van de Hoef, M. Bax, and P. Damman et al. Impaired coronary autoregulation is associated with long-term fatal events in patients with stable coronary artery disease Circ Cardiovasc Interv 6 2013 329 335
8. R. Bugiardini, and C.N. Bairey Merz Angina with "normal" coronary arteries: a changing philosophy JAMA 293 2005 477 484
9. A. Yilmaz, S. Hill, T. Schaufele, M. Vohringer, A. Geissler, and U. Sechtem Exercise-induced spastic coronary artery occlusion at the site of a moderate stenosis: neither Prinzmetal's angina nor cardiac syndrome X but "Prinzmetal X" Circulation 122 2010 e570 e574
10. P.G. Camici, and F. Crea Coronary microvascular dysfunction N Engl J Med 356 2007 830 840
11. V. Pasceri, G.A. Lanza, A. Buffon, A.S. Montenero, F. Crea, and A. Maseri Role of abnormal pain sensitivity and behavioral factors in determining chest pain in syndrome X J Am Coll Cardiol 31 1998 62 66
12. J.P. Halcox, W.H. Schenke, and G. Zalos et al. Prognostic value of coronary vascular endothelial dysfunction Circulation 106 2002 653 658
13. C.J. Pepine, R.D. Anderson, and B.L. Sharaf et al. Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) study J Am Coll Cardiol 55 2010 2825 2832
14. D.D. Waters, D.D. Miller, and J. Szlachcic et al. Factors influencing the long-term prognosis of treated patients with variant angina Circulation 68 1983 258 265
15. Y. Takagi, J. Takahashi, and S. Yasuda et al. Prognostic stratification of patients with vasospastic angina: a comprehensive clinical risk score developed by the Japanese Coronary Spasm Association J Am Coll Cardiol 62 2013 1144 1153
16. M.E. Bertrand, J.M. Lablanche, and P.Y. Tilmant Treatment of Prinzmetal's variant angina. Role of medical treatment with nifedipine and surgical coronary revascularization combined with plexectomy Am J Cardiol 47 1981 174 178
17. F. Iachini Bellisarii, F. Radico, F. Muscente, J. Horowitz, and R. De Caterina Nitrates and other nitric oxide donors in cardiology: current positioning and perspectives Cardiovasc Drugs Ther 26 2012 55 69
18. R.M. Robertson, A.J. Wood, W.K. Vaughn, and D. Robertson Exacerbation of vasotonic angina pectoris by propranolol Circulation 65 1982 281 285
19. L. Kalinowski, L.W. Dobrucki, and M. Szczepanska-Konkel et al. Third-generation beta-blockers stimulate nitric oxide release from endothelial cells through ATP efflux: a novel mechanism for antihypertensive action Circulation 107 2003 2747 2752
20. G.A. Lanza, G. Colonna, V. Pasceri, and A. Maseri Atenolol versus amlodipine versus isosorbide-5-mononitrate on anginal symptoms in syndrome X Am J Cardiol 84 1999 854 856
21. C. Pizzi, O. Manfrini, F. Fontana, and R. Bugiardini Angiotensin- converting enzyme inhibitors and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cardiac syndrome X: role of superoxide dismutase activity Circulation 109 2004 53 58
22. A. Villano, A. Di Franco, and R. Nerla et al. Effects of ivabradine and ranolazine in patients with microvascular angina pectoris Am J Cardiol 112 2013 8 13
23. P.K. Mehta, P. Goykhman, and L.E. Thomson et al. Ranolazine improves angina in women with evidence of myocardial ischemia but no obstructive coronary artery disease J Am Coll Cardiol Img 4 2011 514 522
24. N.H. Pijls, B. De Bruyne, and G.J. Bech et al. Coronary pressure measurement to assess the hemodynamic significance of serial stenoses within one coronary artery: validation in humans Circulation 102 2000 2371 2377
25. S. Jost, M. Sturm, D. Hausmann, P. Lippolt, and P.R. Lichtlen Standardization of coronary vasomotor tone with intracoronary nitroglycerin Am J Cardiol 78 1996 120 123
26. Y. Hirano, Y. Ozasa, and T. Yamamoto et al. Hyperventilation and cold-pressor stress echocardiography for noninvasive diagnosis of coronary artery spasm J Am Soc Echocardiogr 14 2001 626 633
27. W. Auch-Schwelk, I. Paetsch, F. Krackhardt, M. Grafe, R. Hetzer, and E. Fleck Modulation of contractions to ergonovine and methylergonovine by nitric oxide and thromboxane A2 in the human coronary artery J Cardiovasc Pharmacol 36 2000 631 639
28. F.A. Heupler Jr., W.L. Proudfit, M. Razavi, E.K. Shirey, R. Greenstreet, and W.C. Sheldon Ergonovine maleate provocative test for coronary arterial spasm Am J Cardiol 41 1978 631 640
29. R. Ginsburg, I.H. Lamb, M.R. Bristow, J.S. Schroeder, and D.C. Harrison Application and safety of outpatient ergonovine testing in accurately detecting coronary spasm in patients with possible variant angina Am Heart J 102 1981 698 702
30. M.A. Morales, M. Lombardi, A. Distante, C. Carpeggiani, B. Reisenhofer, and A. L'Abbate Ergonovine-echo test to assess the significance of chest pain at rest without ECG changes Eur Heart J 16 1995 1361 1366
31. A. Buxton, S. Goldberg, and J.W. Hirshfeld et al. Refractory ergonovine-induced coronary vasospasm: importance of intracoronary nitroglycerin Am J Cardiol 46 1980 329 334
32. D. Hackett, S. Larkin, S. Chierchia, G. Davies, J.C. Kaski, and A. Maseri Induction of coronary artery spasm by a direct local action of ergonovine Circulation 75 1987 577 582
33. S. Sueda, H. Kohno, and H. Fukuda et al. Frequency of provoked coronary spasms in patients undergoing coronary arteriography using a spasm provocation test via intracoronary administration of ergonovine Angiology 55 2004 403 411
34. R.F. Furchgott, and J.V. Zawadzki The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Nature 288 1980 373 376
35. P.L. Ludmer, A.P. Selwyn, and T.L. Shook et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries N Engl J Med 315 1986 1046 1051
36. S. Sueda, H. Kohno, and H. Fukuda et al. Clinical impact of selective spasm provocation tests: comparisons between acetylcholine and ergonovine in 1508 examinations Coron Artery Dis 15 2004 491 497
37. Y. Takagi, S. Yasuda, and J. Takahashi et al. Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications, and prognostic impact: Multicentre Registry Study of the Japanese Coronary Spasm Association Eur Heart J 34 2013 258 267
38. A. Maseri, G. Davies, D. Hackett, and J.C. Kaski Coronary artery spasm and vasoconstriction. The case for a distinction Circulation 81 1990 1983 1991
39. H.J. Jang, B.K. Koo, and H.S. Lee et al. Safety and efficacy of a novel hyperaemic agent, intracoronary nicorandil, for invasive physiological assessments in the cardiac catheterization laboratory Eur Heart J 34 2013 2055 2062
40. B. De Bruyne, N.H. Pijls, L. Smith, M. Wievegg, and G.R. Heyndrickx Coronary thermodilution to assess flow reserve: experimental validation Circulation 104 2001 2003 2006
41. W.F. Fearon, L.B. Balsam, and H.M. Farouque et al. Novel index for invasively assessing the coronary microcirculation Circulation 107 2003 3129 3132
42. M.K. Ng, A.C. Yeung, and W.F. Fearon Invasive assessment of the coronary microcirculation: superior reproducibility and less hemodynamic dependence of index of microcirculatory resistance compared with coronary flow reserve Circulation 113 2006 2054 2061
43. M. Echavarria-Pinto, J. Escaned, and E. Macias et al. Disturbed coronary hemodynamics in vessels with intermediate stenoses evaluated with fractional flow reserve: a combined analysis of epicardial and microcirculatory involvement in ischemic heart disease Circulation 128 2013 2557 2566
44. P. Voci, G. Testa, and G. Plaustro Imaging of the distal left anterior descending coronary artery by transthoracic color-Doppler echocardiography Am J Cardiol 81 1998 74G 78G
45. L. Galiuto, A. Sestito, and S. Barchetta et al. Noninvasive evaluation of flow reserve in the left anterior descending coronary artery in patients with cardiac syndrome X Am J Cardiol 99 2007 1378 1383
46. R. Vogel, A. Indermuhle, and J. Reinhardt et al. The quantification of absolute myocardial perfusion in humans by contrast echocardiography: algorithm and validation J Am Coll Cardiol 45 2005 754 762
47. A. Yilmaz, A. Athanasiadis, and H. Mahrholdt et al. Diagnostic value of perfusion cardiovascular magnetic resonance in patients with angina pectoris but normal coronary angiograms assessed by intracoronary acetylcholine testing Heart 96 2010 372 379
48. P.A. Kaufmann, and P.G. Camici Myocardial blood flow measurement by PET: technical aspects and clinical applications J Nucl Med 46 2005 75 88
49. M.L. Storto, R. Marano, N. Maddestra, M. Caputo, M. Zimarino, and L. Bonomo Images in cardiovascular medicine. Multislice spiral computed tomography for in-stent restenosis Circulation 105 2002 2005
50. R.T. George, A. Arbab-Zadeh, and R.J. Cerci et al. Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320-MDCT: the CT angiography and perfusion methods of the CORE320 multicenter multinational diagnostic study AJR Am J Roentgenol 197 2011 829 837
51. J.M. Tarkin, S. Nijjer, and S. Sen et al. Hemodynamic response to intravenous adenosine and its effect on fractional flow reserve assessment: results of the Adenosine for the Functional Evaluation of Coronary Stenosis Severity (AFFECTS) study Circ Cardiovasc Interv 6 2013 654 661
52. S.E. Reis, R. Holubkov, and A.J. Conrad Smith et al. Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study Am Heart J 141 2001 735 741