MiR-135a-5p inhibits 3T3-L1 adipogenesis through activation of canonical Wnt/b-catenin signaling

Journal of Molecular Endocrinology

Volumn 52, Issue 3, 2014, Pages 311-320

  Chen, Chen ^a,b   Peng, Yongdong ^a   Peng, Yinglin ^b   Peng, Jian ^a   Jiang, Siwen ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^b Hunan Institute of Animal and Veterinary Science   (China)

Author keywords

3T3 L1 preadipocyte differentiation; Adipogenesis; APC; MiR 135a 5p; Wnt catenin

Indexed keywords

BETA CATENIN; CYCLIN D1; FAT DROPLET; MICRORNA; MICRORNA 135A 5P; SMALL INTERFERING RNA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; WNT PROTEIN; CCAAT ENHANCER BINDING PROTEIN; CCND1 PROTEIN, MOUSE; CEBPA PROTEIN, MOUSE; FABP4 PROTEIN, MOUSE; FATTY ACID BINDING PROTEIN; FATTY ACID SYNTHASE; MIRN135 MICRORNA, MOUSE; MYC PROTEIN; MYC PROTEIN, MOUSE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

3T3 CELL LINE; ADIPOGENESIS; ANIMAL CELL; APC GENE; ARTICLE; CELL DIFFERENTIATION; CELL NUCLEUS; CMYC GENE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; GENE; GENE EXPRESSION; GENE FUNCTION; GENE OVEREXPRESSION; GENE TARGETING; MARKER GENE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; ACTIVE TRANSPORT; ADIPOCYTE; ADIPOSE TISSUE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; COLON POLYPOSIS; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; METABOLISM; RNA INTERFERENCE; WNT SIGNALING PATHWAY;

3T3-L1 CELLS; ACTIVE TRANSPORT, CELL NUCLEUS; ADENOMATOUS POLYPOSIS COLI; ADIPOCYTES; ADIPOGENESIS; ADIPOSE TISSUE; ANIMALS; BETA CATENIN; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; CRICETINAE; CYCLIN D1; FATTY ACID SYNTHASES; FATTY ACID-BINDING PROTEINS; GENE EXPRESSION REGULATION; MICE; MICRORNAS; PPAR GAMMA; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; RNA, SMALL INTERFERING; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84901326224     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-14-0013     Document Type: Article

References (37)

1. Ambros V. 2003 microRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell 113 673-676. (doi:10.1016/S0092-8674(03)00428-8)
2. Antonson P., Pray MG, Jacobsson A & Xanthopoulos KG 1995 Myc inhibits CCAAT/enhancer-binding protein a-gene expression in HIB-1B hibernoma cells through interactions with the core promoter region. European Journal of Biochemistry 232 397-403. (doi:10.1111/j.1432-1033.1995.397zz.x)
3. Bartel D. P 2004 MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116 281-297. (doi:10.1016/S0092-8674 (04)00045-5)
4. Bhushan R., Grünhagen J, Becker J, Robinson PN, Ott CE & Knaus P 2013 miR-181a promotes osteoblastic differentiation through repression of TGF-b signaling molecules. International Journal of Biochemistry & Cell Biology 45 696-705. (doi:10.1016/j.biocel.2012.12.008)
5. Chen C., Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, Barbisin M, Xu L., Mahuvakar VR, Andersen MR et al. 2005 Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Research 33 e179. (doi:10.1093/nar/gni178)
6. Chen C., Deng B, Qiao M, Zheng R, Chai J, Ding Y, Peng J & Jiang S 2012 Solexa sequencing identification of conserved and novel microRNAs in backfat of large white and chinese meishan pigs. PLoS ONE 7 e31426. (doi:10.1371/journal.pone.0031426)
7. Christodoulides C., Lagathu C, Sethi JK & Vidal-Puig A 2009 Adipogenesis and WNT signalling. Trends in Endocrinology and Metabolism 20 16-24. (doi:10.1016/j.tem.2008.09.002)
8. Esau C., Kang X, Peralta E, Hanson E, Marcusson EG, Ravichandran LV, Sun Y., Koo S, Perera RJ, Jain R et al. 2004 MicroRNA-143 regulates adipocyte differentiation. Journal of Biological Chemistry 279 52361-52365. (doi:10.1074/jbc.C400438200)
9. Freytag S. O & Geddes TJ 1992 Reciprocal regulation of adipogenesis by Myc and C/EBPa. Science 256 379-382. (doi:10.1126/science.256.5055.379)
10. Fu M., Rao M, Bouras T, Wang C, Wu K, Zhang X, Li Z, Yao TP & Pestell RG Cyclin D1 inhibits peroxisome proliferators-activated receptor g-mediated adipogenesis through histone deacetylase recruitment. Journal of Biological Chemistry 280 16934-16941. (doi:10.1074/ jbc.M500403200)
11. Guo H., Hu X, Ge S, Qian G & Zhang J 2012 Regulation of RAP1B by miR-139 suppresses human colorectal carcinoma cell proliferation. International Journal of Biochemistry & Cell Biology 44 1465-1472. (doi:10.1016/j.biocel.2012.05.015)
12. He T. C, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B. & Kinzler KW 1998 Identification of c-MYC as a target of the APC pathway. Science 281 1509-1512. (doi:10.1126/science.281. 5382.1509)
13. Ho S. N, Hunt HD, Horton RM, Pullen JK & Pease LR 1989 Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77 51-59. (doi:10.1016/0378-1119(89)90358-2)
14. Hotamisligil G. S, Shargill NS & Spiegelman BM 1993 Adipose expression of tumor necrosis factor-a: direct role in obesity-linked insulin resistance. Science 259 87-91. (doi:10.1126/science.7678183)
15. Kahn B. B & Flier JS 2000 Obesity and insulin resistance. Journal of Clinical Investigation 106 473-481. (doi:10.1172/JCI10842)
16. Karbiener M., Fischer C, Nowitsch S, Opriessnig P, Papak C, Ailhaud G, Dani C., Amri EZ & Scheideler M 2009 microRNA miR-27b impairs human adipocyte differentiation and targets PPARg. Biochemical and Biophysical Research Communications 390 247-251. (doi:10.1016/ j.bbrc.2009.09.098)
17. Kennell J. A, Gerin I, MacDougald OA & Cadigan KM 2008 The microRNA miR-8 is a conserved negative regulator of Wnt signaling. PNAS 105 15417-15422. (doi:10.1073/pnas.0807763105)
18. Kim S. Y, Kim AY, Lee HW, Son YH, Lee GY, Lee JW, Lee YS & Kim JB 2010 miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARg expression. Biochemical and Biophysical Research Communications 392 323-328. (doi:10.1016/j.bbrc.2010.01.012)
19. Lee E. K, LeeMJ, Abdelmohsen K, KimW, KimMM, Srikantan S, Martindale JL, Hutchison E. R, Kim HH, Marasa BS et al. 2011 miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor g expression. Molecular and Cellular Biology 31 626-638. (doi:10.1128/ MCB.00894-10)
20. Lefterova M. I & Lazar MA 2009 New developments in adipogenesis. Trends in Endocrinology and Metabolism 20 107-114. (doi:10.1016/j.tem.2008. 11.005)
21. Li Z., Hassan MQ, Volinia S, van Wijnen AJ, Stein JL, Croce CM, Lian J & Stein G. S 2008 A microRNA signature for a BMP2-induced osteoblast lineage commitment program. PNAS 105 13906-13911. (doi:10.1073/ pnas.0804438105)
22. Liang W., Wang Y, Wan D, Yeung VS & Waye MM 2013 Characterization of miR-210 in 3T3-L1 adipogenesis. Journal of Cellular Biochemistry 2699-2707. (doi:10.1002/jcb.24617)
23. Ling H., Wen G, Feng S, Tuo Q, Ou H, Yao C, Zhu B, Gao Z, Zhang L & Liao D MicroR. NA-375 promotes 3T3-L1 adipocyte differentiation through modulation of extracellular signal-regulated kinase signalling. Clinical and Experimental Pharmacology & Physiology 38 239-246. (doi:10.1111/j.1440-1681.2011.05493.x)
24. Longo K. A, Wright WS, Kang S, Gerin I, Chiang SH, Lucas PC, Opp MR & MacDougald O. A 2004 Wnt10b inhibits development of white and brown adipose tissues. Journal of Biological Chemistry 279 35503-35509. (doi:10.1074/jbc.M402937200)
25. Mann B., Gelos M, Siedow A, Hanski ML, Gratchev A, Ilyas M, Bodmer WF, Moyer M. P, Riecken EO, Buhr HJ et al. 1999 Target genes of b-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. PNAS 1999 1603-1608. (doi:10.1073/pnas.96.4.1603)
26. Martinelli R., NardelliC, Pilone V, BuonomoT, Liquori R, Castano I, Buono P, Masone S., Persico G, Forestieri P et al. 2010 miR-519d overexpression is associated with human obesity. Obesity 18 2170-2176. (doi:10.1038/ oby.2009.474)
27. Miclea R. L, van der Horst G, Robanus-Maandag EC, Löwik CW, Oostdijk W, Wit J. M & Karperien M 2011 Apc bridges Wnt/b-catenin and BMP signaling during osteoblast differentiation of KS483 cells. Experimental Cell Research 317 1411-1421. (doi:10.1016/j.yexcr.2011.03.007)
28. Nagel R., Ie Sage C, Diosdado B, van der Waal M, Oude Vrielink JA, Bolijn A., Meijer GA & Agami R 2008 Regulation of the adenomatous polyposis coli gene by the miR-135a-5p family in colorectal cancer. Cancer Research 68 5795-5802. (doi:10.1158/0008-5472.CAN-08-0951)
29. Peng Y., Xiang H, Chen C, Zheng R, Chai J, Peng J & Jiang S 2013 miR-224 impairs adipocyte early differentiation and regulates fatty acid metabolism. International Journal of Biochemistry & Cell Biology 45 1585-1593. (doi:10.1016/j.biocel.2013.04.029)
30. Qin L., Chen Y, Niu Y, Chen W, Wang Q, Xiao S, Li A, Xie Y, Li J, Zhao X et al. 2010 A deep investigation into the adipogenesis mechanism: profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/b-catenin signaling pathway. BMC Genomics 11 320. (doi:10.1186/1471-2164-11-320)
31. Ross S. E, Hemati N, Longo KA, Bennett CN, Lucas PC, Erickson RL & MacDougald O. A 2000 Inhibition of adipogenesis by Wnt signaling. Science 289 950-953. (doi:10.1126/science.289.5481.950)
32. Shtutman M., Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R & Ben-Ze'ev A 1999 The cyclin D1 gene is a target of the b-catenin/LEF-1 pathway. PNAS 96 5522-5527. (doi:10.1073/pnas.96.10.5522)
33. Sõber S., Laan M & Annilo T 2010 MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene (NR3C2) expression. Biochemical and Biophysical Research Communications 391 727-732. (doi:10.1016/j.bbrc.2009.11.128)
34. Sun T., Fu M, Bookout AL, Kliewer SA & Mangelsdorf DJ 2009 MicroRNA let-7 regulates 3T3-L1 adipogenesis. Molecular Endocrinology 23 925-931. (doi:10.1210/me.2008-0298)
35. Tetsu O. & McCormick F 1999 b-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398 422-426. (doi:10.1038/18884)
36. Wang Q., Li Y, Wang J, Kong J, Qi Y, Quigg RJ & Li X 2008 miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumorsuppressor Rb2/p130. PNAS 105 2889-2894. (doi:10.1073/pnas. 0800178105)
37. Yi C., Xie W, Li F, Lv Q, He J, Wu J, Gu D, Xu N & Zhang Y 2011 miR-143 enhances adipogenic differentiation of 3T3-L1 cells through targeting the coding region of mouse pleiotrophin. FEBS Letters 585 3303-3309. (doi:10.1016/j.febslet.2011.09.015)