Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin

Genetics

Volumn 196, Issue 2, 2014, Pages 557-567

  He, Bin Z ^a,e   Ludwig, Michael Z ^a   Dickerson, Desiree A ^a   Barse, Levi ^a   Arun, Bharath ^a   Vilhjálmsson, Bjarni J ^b   Jiang, Pengyao ^a   Park, Soo Young ^a   Tamarina, Natalia A ^a   Selleck, Scott B ^c   Wittkopp, Patricia J ^d   Bell, Graeme I ^a   Kreitman, Martin ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e HARVARD UNIVERSITY   (United States)

Author keywords

Drosophila; Genome wide association study; Heparan sulfate proteoglycan; Mutant insulin; Sulfateless

Indexed keywords

HEPARAN SULFATE; MUTANT PROTEIN; PROINSULIN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME 3; CONTROLLED STUDY; DIABETES MELLITUS; DROSOPHILA MELANOGASTER; EPISTASIS; FEMALE; GENE; GENE EXPRESSION; GENE INTERACTION; GENE MAPPING; GENE MUTATION; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HAPLOTYPE; HETEROZYGOTE; INTRON; MALE; MARKER GENE; MISFOLDED PROTEIN RESPONSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; QUANTITATIVE TRAIT LOCUS; RNA INTERFERENCE; SFL GENE;

DROSOPHILA; GENOME-WIDE ASSOCIATION STUDY; HEPARAN SULFATE PROTEOGLYCAN; MUTANT INSULIN; SULFATELESS;

ALLELES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EPISTASIS, GENETIC; EYE; FEMALE; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HEPARITIN SULFATE; HUMANS; INTRONS; MALE; MUTATION; PHENOTYPE; PROINSULIN; PROTEIN FOLDING; RNA INTERFERENCE; SULFOTRANSFERASES;

EID: 84901323480     PISSN: 00166731     EISSN: 19432631     Source Type: Journal    
DOI: 10.1534/genetics.113.157800     Document Type: Article

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