Timing of antimicrobial therapy after identification of ventilator-associated condition is not associated with mortality in patients with ventilator-associated pneumonia: A cohort study

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Amaral, André C K B ^a,b   Holder, Michael W ^a,c  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT;

ADULT; ANTIMICROBIAL THERAPY; ARTICLE; ARTIFICIAL VENTILATION; COHORT ANALYSIS; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DISEASE ASSOCIATION; FEMALE; HUMAN; INFECTION RISK; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; NONHUMAN; RETROSPECTIVE STUDY; RISK ASSESSMENT; SUPERINFECTION; TREATMENT FAILURE; VENTILATOR ASSOCIATED PNEUMONIA; AGED; MIDDLE AGED; PNEUMONIA, VENTILATOR-ASSOCIATED; STATISTICS AND NUMERICAL DATA; TIME; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTI-INFECTIVE AGENTS; COHORT STUDIES; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PNEUMONIA, VENTILATOR-ASSOCIATED; TIME FACTORS;

EID: 84901321856     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097575     Document Type: Article

References (34)

1. Chastre J, Fagon JY (2002) Ventilator-associated pneumonia. Am J Respir Crit Care Med 165: 867-903. (Pubitemid 34774654)
2. Klompas M (2007) Does This Patient Have Ventilator-Associated Pneumonia? JAMA: The Journal of the American Medical Association 297: 1583-1593.
3. Stevens JP, Kachniarz B, Wright SB, Gillis J, Talmor D, et al. (2013) When Policy Gets It Right: Variability in U.S. Hospitals' Diagnosis of Ventilator-Associated Pneumonia. Crit Care Med.
4. Magill SS, Fridkin SK (2012) Improving surveillance definitions for ventilator-associated pneumonia in an era of public reporting and performance measurement. Clin Infect Dis 54: 378-380.
5. Klompas M (2013) Ventilator-associated events surveillance: a patient safety opportunity. Curr Opin Crit Care 19: 424-431.
6. Klompas M, Khan Y, Kleinman K, Evans RS, Lloyd JF, et al. (2011) Multicenter evaluation of a novel surveillance paradigm for complications of mechanical ventilation. PLoS One 6: e18062.
7. Muscedere J, Sinuff T, Heyland DK, Dodek PM, Keenan SP, et al. (2013) The clinical impact and preventability of ventilator-associated conditions in critically ill patients who are mechanically ventilated. Chest 144: 1453-1460.
8. Moscucci M, Eagle KA, Share D, Smith D, De Franco AC, et al. (2005) Public Reporting and Case Selection for Percutaneous Coronary Interventions: An Analysis From Two Large Multicenter Percutaneous Coronary Intervention Databases. Journal of the American College of Cardiology 45: 1759-1765. (Pubitemid 40779853)
9. Wachter RM, Flanders SA, Fee C, Pronovost PJ (2008) Public Reporting of Antibiotic Timing in Patients with Pneumonia: Lessons from a Flawed Performance Measure. Annals of Internal Medicine 149: 29-32.
10. Muller MP, Detsky AS (2010) Public Reporting of Hospital Hand Hygiene Compliance-Helpful or Harmful? JAMA: The Journal of the American Medical Association 304: 1116-1117.
11. Muscedere J, Dodek P, Keenan S, Fowler R, Cook D, et al. (2008) Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia: diagnosis and treatment. J Crit Care 23: 138-147. (Pubitemid 351400356)
12. Metersky ML, Sweeney TA, Getzow MB, Siddiqui F, Nsa W, et al. (2006) Antibiotic Timing and Diagnostic Uncertainty in Medicare Patients With Pneumonia*. Chest 130: 16-21.
13. Welker JA, Huston M, McCue JD (2008) Antibiotic Timing and Errors in Diagnosing Pneumonia. Archives of Internal Medicine 168: 351-356. (Pubitemid 351347125)
14. Klompas M, Magill S, Robicsek A, Strymish JM, Kleinman K, et al. (2012) Objective surveillance definitions for ventilator-associated pneumonia. Crit Care Med 40: 3154-3161.
15. Muscedere J, Dodek P, Keenan S, Fowler R, Cook D, et al. (2008) Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia: prevention. J Crit Care 23: 126-137. (Pubitemid 351400352)
16. Committee AaIG (2005) Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 171: 388-416.
17. Lunn M, McNeil D (1995) Applying Cox regression to competing risks. Biometrics 51: 524-532.
18. Alvarez-Lerma F (1996) Modification of empiric antibiotic treatment in patients with pneumonia acquired in the intensive care unit. ICU-Acquired Pneumonia Study Group. Intensive Care Med 22: 387-394.
19. Luna CM, Vujacich P, Niederman MS, Vay C, Gherardi C, et al. (1997) Impact of BAL data on the therapy and outcome of ventilator-associated pneumonia. Chest 111: 676-685. (Pubitemid 27132946)
20. Dupont H, Mentec H, Sollet JP, Bleichner G (2001) Impact of appropriateness of initial antibiotic therapy on the outcome of ventilator-associated pneumonia. Intensive Care Med 27: 355-362. (Pubitemid 32249978)
21. Kollef MH, Ward S (1998) The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumonia. Chest 113: 412-420. (Pubitemid 28110020)
22. Mueller EW, Hanes SD, Croce MA, Wood GC, Boucher BA, et al. (2005) Effect from multiple episodes of inadequate empiric antibiotic therapy for ventilator-associated pneumonia on morbidity and mortality among critically ill trauma patients. J Trauma 58: 94-101.
23. Torres A, Aznar R, Gatell JM, Jimenez P, Gonzalez J, et al. (1990) Incidence, risk, and prognosis factors of nosocomial pneumonia in mechanically ventilated patients. Am Rev Respir Dis 142: 523-528. (Pubitemid 20292709)
24. Hranjec T, Rosenberger LH, Swenson B, Metzger R, Flohr TR, et al. (2012) Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: a quasi-experimental, before and after observational cohort study. Lancet Infect Dis 12: 774-780.
25. Luna CM, Aruj P, Niederman MS, Garzón J, Violi D, et al. (2006) Appropriateness and delay to initiate therapy in ventilator-associated pneumonia. European Respiratory Journal 27: 158-164. (Pubitemid 43092680)
26. Iregui M, Ward S, Sherman G, Fraser VJ, Kollef MH (2002) Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 122: 262-268. (Pubitemid 34754172)
27. Bekaert M, Timsit JF, Vansteelandt S, Depuydt P, Vesin A, et al. (2011) Attributable Mortality of Ventilator Associated Pneumonia: A Reappraisal Using Causal Analysis. Am J Respir Crit Care Med.
28. Kollef MH, Ward S (1998) The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumonia. Chest 113: 412-420. (Pubitemid 28110020)
29. Micek ST, Lloyd AE, Ritchie DJ, Reichley RM, Fraser VJ, et al. (2005) Pseudomonas aeruginosa Bloodstream Infection: Importance of Appropriate Initial Antimicrobial Treatment. Antimicrobial Agents and Chemotherapy 49: 1306-1311. (Pubitemid 40463352)
30. Klompas M (2010) Interobserver variability in ventilator-associated pneumonia surveillance. American Journal of Infection Control 38: 237-239.
31. Fagon JY, Chastre J, Wolff M, Gervais C, Parer-Aubas S, et al. (2000) Invasive and Noninvasive Strategies for Management of Suspected Ventilator-Associated Pneumonia: A Randomized Trial. Annals of Internal Medicine 132: 621-630. (Pubitemid 30217554)
32. Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, et al. (2006) Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 34: 1589-1596. (Pubitemid 43810035)
33. Baker AMM, Meredith JW, Chang M, Dunagan D, Smith A, Haponik E (2003) Bronchoscopically guided management of ventilator-associated pneumonia in trauma patients. J Bronchology 10: 7-16. (Pubitemid 36254371)
34. Vittinghoff E, McCulloch CE (2007) Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol 165: 710-718. (Pubitemid 46348374)