Direct analysis of 18 flavonol glycosides, aglycones and terpene trilactones in Ginkgo biloba tablets by matrix solid phase dispersion coupled with ultra-high performance liquid chromatography tandem triple quadrupole mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 97, Issue , 2014, Pages 123-128

  Liu, Xin Guang ^a   Yang, Hua ^a   Cheng, Xiao Lan ^a   Liu, Lei ^a   Qin, Yong ^a   Wang, Qi ^a   Qi, Lian Wen ^a,b   Li, Ping ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

Flavonol glycoside; Ginkgo biloba; Matrix solid phase dispersion; Terpene trilactone; Triple quadrupole mass spectrometry

Indexed keywords

AGLYCONE; APIGENIN 3 O GLUCOSIDE; BILOBALIDE; FLAVONOID GLYCOSIDE; GINKGOLIDE A; GINKGOLIDE B; GINKGOLIDE C; GINKGOLIDE J; ISOQUERCITRIN; ISORHAMNETIN; ISORHAMNETIN 3 O NEOHESPERIDOSIDE; ISORHAMNETIN 3 O RUTINOSIDE; KAEMPFEROL; KAEMPFEROL 3 O 2'' (6'' 4 COUMAROYL) GLUCOSYL RHAMNOSIDE; KAEMPFEROL 3 O 2'' GLUCOSYLRHAMNOSIDE; LACTONE DERIVATIVE; NICOTIFLORIN; QUERCETIN; QUERCETIN 3 O 2'' (6'' 4 COUMAROYL) GLUCOSYL RHAMNOSIDE; QUERCITRIN; RUTOSIDE; UNCLASSIFIED DRUG; FLAVONOL DERIVATIVE; GLYCOSIDE; LACTONE; TABLET; TERPENE;

ANALYTIC METHOD; ARTICLE; GINKGO BILOBA; LIMIT OF QUANTITATION; MATRIX SOLID PHASE DISPERSION; NONHUMAN; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; QUALITY CONTROL; QUANTITATIVE ANALYSIS; SOLID PHASE EXTRACTION; TABLET; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; VALIDATION STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAVONOLS; GINKGO BILOBA; GLYCOSIDES; LACTONES; MASS SPECTROMETRY; SOLID PHASE EXTRACTION; TABLETS; TERPENES;

EID: 84901312799     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.04.027     Document Type: Article

References (16)

1. Cheuvront S.N., Carter R. Ginkgo and memory. JAMA 2003, 289:547-548.
2. Birks J., GrimLey E.J. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst. Rev. 2009, 1:CD003120.
3. Amieva H., Meillon C., Helmer C., Barberger-Gateau P., Dartigues J.F. Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study. PLoS One 2013, 8:e52755.
4. Vellas B., Coley N., Ousset P.J., Berrut G., Dartigues J.F., Dubois B., Grandjean H., Pasquier F., Piette F., Robert P., Touchon J., Garnier P., Mathiex F.H., Andrieu S. Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial. Lancet Neurol. 2012, 11:851-859. GuidAge Study Group.
5. Sora D.I., Stefanescu V., David V., Medvedovici A. Validation of an LC-MS/MS assay of terpene trilactones in Ginkgo biloba extracts and pharmaceutical formulations through standard addition method. J. Pharm. Biomed. Anal. 2009, 50(3):459-468.
6. Avula B., Wang Y.H., Smillie T.J., Khan I.A. Column liquid chromatography/electrospray ionization-time of flight-mass spectrometry and ultra performance column liquid chromatography/mass spectrometry methods for the determination of ginkgolides and bilobalide in the leaves of Ginkgo biloba and dietary supplements. J. AOAC Int. 2009, 92(2):645-652.
7. United States Pharmacopoeial Convention United States Pharmacopeial 34-NF29 2011, 1602-1611. Dietary Supplements, Rockville, MD.
8. European Directorate for the Quality of Medicines and HealthCare European Pharmacopoeia 2010, 1136-1140. European Directorate for the Quality of Medicines & HealthCare, Strasbourg. seventh ed.
9. van Beek T.A., Montoro P. Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals. J. Chromatogr. A 2009, 1216:2002-2032.
10. Dubber M.J., Sewram V., Mshicileli N., Shephard G.S., Kanfer I. The simultaneous determination of selected flavonol glycosides and aglycones in Ginkgo biloba oral dosage forms by high-performance liquid chromatography-electrospray ionisation-mass spectrometry. J. Pharm. Biomed. Anal. 2005, 37:723-731.
11. X. Yao, G.S. Zhou, Y.P. Tang, Y.F. Qian, H.L. Guan, H. Qi. Pang, S.Q. Zhu, X. Mo, S.L. Su, C. Jin, Y. Qin, D.W. Qian, J.A. Duan. Simultaneous quantification of flavonol glycosides, terpene lactones, biflavones, proanthocyanidins, and ginkgolic acids in Ginkgo biloba leaves from fruit cultivars by ultrahigh-performance liquid chromatography coupled with triple quadrupole mass spectrometry, BioMed Res. Int. http://dx.doi.org/10.1155/2013/582591.
12. Ding S.J., Dudley E., Plummer S., Tang J., Newton R.P., Brenton A.G. Quantitative determination of major active components in Ginkgo biloba dietary supplements by liquid chromatography/mass spectrometry. Phytochemistry 2008, 69:1555-1564.
13. Dawidowicz A.L., Rado E. Matrix solid-phase dispersion (MSPD) in chromatographic analysis of essential oils in herbs. J. Pharm. Biomed. Anal. 2010, 52(1):79-85.
14. Cheng X.L., Qi L.W., Wang Q., Liu X.G., Boubertakh B., Wan J.Y., Liu E.H., Li P. Highly efficient sample preparation and quantification of constituents from traditional Chinese herbal medicines using matrix solid-phase dispersion extraction and UPLC-MS/MS. Analyst 2013, 138:2279-2288.
15. Yasuhiro K., Takashi H., Takeshi I., Yukihiro G., Naoki M. Comprehensive analysis of flavonols in Ginkgo biloba products by ultra-high-performance liquid chromatography coupled with ultra-violet detection and time-of-flight mass spectrometry. Biosci. Biotechnol., Biochem. 2012, 76:1003-1007.
16. Chen E., Ding C., Lindsay R.C. Qualitative and quantitative analyses of ginkgo terpene trilactones by liquid chromatography/sonic spray ionization ion trap mass spectrometry. Anal. Chem. 2005, 77:2966-2970.