The effects of BMSCs transplantation on autophagy by CX43 in the hippocampus following traumatic brain injury in rats

Neurological Sciences

Volumn 35, Issue 5, 2014, Pages 677-682

  Sun, Liqian ^a   Gao, Junling ^b   Zhao, Manman ^b   Jing, Xiaobin ^c   Cui, Ying ^a   Xu, Xiaoyu ^a   Wang, Kaijie ^a   Zhang, Wenqian ^a   Cui, Jianzhong ^a  

^a TANGSHAN GONGREN HOSPITAL   (China)

^b HEBEI UNITED UNIVERSITY   (China)

^c TANGSHAN PEOPLE S HOSPITAL   (China)

Author keywords

Autophagy; BMSCs; CX43; Hippocampus; Traumatic brain injury

Indexed keywords

BECLIN 1; CONNEXIN 43; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, RAT; CONNEXIN 43 PROTEIN, RAT; LC3 PROTEIN, RAT; MICROTUBULE ASSOCIATED PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BONE MARROW TRANSPLANTATION; BRAIN TISSUE; CONTROLLED STUDY; DOWN REGULATION; ELECTRON MICROSCOPY; HIPPOCAMPUS; IMMUNOBLOTTING; LIGHT CHAIN; MALE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; STROMA CELL; TRAUMATIC BRAIN INJURY; WESTERN BLOTTING; ANIMAL; BRAIN INJURIES; CELL CULTURE; FEMALE; MESENCHYMAL STEM CELL TRANSPLANTATION; METABOLISM; MITOCHONDRION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BRAIN INJURIES; CELLS, CULTURED; CONNEXIN 43; DOWN-REGULATION; FEMALE; HIPPOCAMPUS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY;

EID: 84901312590     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-013-1575-6     Document Type: Article

References (15)

1. Zhang M, Shan H, Gu Z, Wang D, Wang T, Wang Z, Tao L (2012) Increased expression of calcium/calmodulin-dependent protein kinase type II subunit delta after rat traumatic brain injury. J Mol Neurosci 46(3):631-643
2. Clark RS, Bay H, Chu CT, Alber SM, Kochanek PM, Watkins SC (2008) Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness. Autophagy 4(1):88-90
3. Sadasivan S, Dunn WA Jr, Hayes RL, Wang KK (2008) Changes in autophagy proteins in a rat model of controlled cortical impact induced brain injury. Biochem Biophys Res Commun 373(4):478-481
4. Wang T, Zhang L, Zhang M, Bao H, Liu W, Wang Y, Wang L, Dai D, Chang P, Dong W (2012) [Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice. Neuroscience 231:70-81
5. Lai Y, Hickey RW, Yaming Chen HB (2007) Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant γ-glutamylcysteinyl ethyl ester. J Cereb Blood Flow Metab 28(3):540-550 (Pubitemid 351304265)
6. Luo C-L, Li B-X, Chen X-P, Sun Y-X, Bao H-J, Dai D-K, Shen Y-W, Xu H-F, Ni H, Wan L (2011) Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice. Neuroscience 184:54-63
7. Mahmood A, Lu D, Qu C, Goussev A, Chopp M (2007) Treatment of traumatic brain injury with a combination therapy of marrow stromal cells and atorvastatin in rats. Neurosurgery 60(3):546-554
8. Osanai T, Kuroda S, Sugiyama T, Kawabori M, Ito M, Shichinohe H, Kuge Y, Houkin K, Tamaki N, Iwasaki Y (2012) Therapeutic effects of intra-arterial delivery of bone marrow stromal cells in traumatic brain injury of rats - in vivo cell tracking study by near-infrared fluorescence imaging. Neurosurgery 70(2):435-444
9. Marmarou A, Foda MAA-E, Brink Wvd, Campbell J, Kita H, Demetriadou K (1994) A new model of diffuse brain injury in rats: Part I: Pathophysiology and biomechanics. J Neurosurg 80(2):291-300 (Pubitemid 24036501)
10. Bakhtiary M, Marzban M, Mehdizadeh M, Joghataei MT, Khoei S, Laribi B, Tondar M, Moshkforoush A (2010) Comparison of transplantation of bone marrow stromal cells (BMSC) and stem cell mobilization by granulocyte colony stimulating factor after traumatic brain injury in rat. Iranian Biomed J 14(4):142-149
11. Mizushima N (2004) Methods for monitoring autophagy. Int J Biochem Cell Biol 36(12):2491-2502
12. Kuroda S, Shichinohe H, Houkin K, Iwasaki Y (2011) Autologous bone marrow stromal cell transplantation for central nervous system disorders - recent progress and perspective for clinical application. J Stem Cell Regen Med 7(1):2-13
13. Mahmood A, Goussev A, Lu D, Qu C, Xiong Y, Kazmi H, Chopp M (2008) Long-lasting benefits after treatment of traumatic brain injury (TBI) in rats with combination therapy of marrow stromal cells (MSCs) and simvastatin. J Neurotrauma 25(12):1441-1447
14. Björklund LM, Sánchez-Pernaute R, Chung S, Andersson T, Chen IYC, McNaught KSP, Brownell A-L, Jenkins BG, Wahlestedt C, Kim K-S (2002) Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci 99(4):2344-2349 (Pubitemid 34169063)
15. Bonilla C, Zurita M, Otero L, Aguayo C, Vaquero J (2009) Delayed intralesional transplantation of bone marrow stromal cells increases endogenous neurogenesis and promotes functional recovery after severe traumatic brain injury. Brain Inj 23(9):760-769