Phosphodiesterase 10a pet radioligand development program: From pig to human

Journal of Nuclear Medicine

Volumn 55, Issue 4, 2014, Pages 595-601

  Plisson, Christophe ^a   Plisson, David ^b   Jakobsen, Steen ^c   Natesan, Sridhar ^d   Salinas, Cristian ^a   Lin, Shu Fei ^b   Labaree, David ^b   Zheng, Ming Qiang ^b   Nabulsi, Nabeel ^b   Marques, Tiago Reis ^d   Kapur, Shitij ^d   Kawanishi, Eiji ^e   Saijo, Takeaki ^e   Gunn, Roger N ^a   Carson, Richard E ^b   Rabiner, Eugenii A ^a,e  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Brain; In vivo; PDE10A; PET

Indexed keywords

CARBON PHOSPHODIESTERASE 10 C 11; CARBON PYRAZOLOPYRIMIDINE 104 C 11; CARBON PYRAZOLOPYRIMIDINE 106 C 11; CARBON PYRAZOLOPYRIMIDINE 107 C 11; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; FLUORINE PYRAZOLOPYRIMIDINE 102 F 18; PHOSPHODIESTERASE 10A; RADIOLIGAND; TRACER; UNCLASSIFIED DRUG;

AFFINITY LABELING; ANIMAL EXPERIMENT; ARTICLE; BABOON; BASAL GANGLION; BINDING KINETICS; BRAIN; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MEGADOSE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEASIBILITY STUDY; HUMAN; HUMAN EXPERIMENT; IC 50; IN VITRO STUDY; ISOTOPE LABELING; METHYLATION; NONHUMAN; OUTCOME ASSESSMENT; PLASMA CONCENTRATION-TIME CURVE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; RADIOCHEMISTRY; RADIOISOTOPE DISTRIBUTION; REACTION ANALYSIS; SWINE;

11C; BRAIN; IN VIVO; PDE10A; PET;

ANIMALS; BRAIN; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; ISOTOPE LABELING; PAPIO; PHOSPHORIC DIESTER HYDROLASES; POSITRON-EMISSION TOMOGRAPHY; QUINOXALINES; RADIOPHARMACEUTICALS; SWINE; TISSUE DISTRIBUTION;

EID: 84901308911     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.113.131409     Document Type: Article

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