DPP-4 inhibitors-renoprotection in diabetic nephropathy?

Diabetes

Volumn 63, Issue 6, 2014, Pages 1829-1830

  Panchapakesan, Usha ^a   Pollock, Carol A ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CATION INDEPENDENT MANNOSE 6 PHOSPHATE RECEPTORE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCOSE; LINAGLIPTIN; MICRORNA 200; MICRORNA 21; MICRORNA 29; RECEPTOR; STREPTOZOCIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

APICAL MEMBRANE; BLOOD PRESSURE REGULATION; CEREBROVASCULAR ACCIDENT; CLINICAL EVALUATION; DIABETIC NEPHROPATHY; DIABETIC PATIENT; DRUG EFFICACY; DRUG HALF LIFE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEART INFARCTION; HOSPITALIZATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY FAILURE; KIDNEY FIBROSIS; KIDNEY PROXIMAL TUBULE; NON INSULIN DEPENDENT DIABETES MELLITUS; NOTE; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RENAL PROTECTION; SIGNAL TRANSDUCTION; UNSTABLE ANGINA PECTORIS;

ANIMALS; DIABETIC NEPHROPATHIES; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; ENDOTHELIAL CELLS; MALE; MESENCHYMAL STROMAL CELLS; PURINES; QUINAZOLINES;

EID: 84901303279     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0366     Document Type: Note

References (5)

1. Kanasaki K, Shi S, Kanasaki M, et al. Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition in a therapeutic regimen. Diabetes 2014; 63:2120-2131
2. Wong MG, Panchapakesan U, Qi W, Silva DG, Chen XM, Pollock CA. Cationindependent mannose 6-phosphate receptor inhibitor (PXS25) inhibits fibrosis in human proximal tubular cells by inhibiting conversion of latent to active TGFbeta1. Am J Physiol Renal Physiol 2011;301:F84-F93
3. Panchapakesan U, Gross S, Gangadharan Komala M, Pegg K, Pollock C. DPP4 inhibition in human kidney proximal tubular cells - renoprotection in diabetic nephropathy? J Diabetes Metab 2013;S9:007
4. Söderberg O, Gullberg M, Jarvius M, et al. Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat Methods 2006;3: 995-1000
5. Kaji K, Yoshiji H, Ikenaka Y, et al. Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats. J Gastroenterol 2014;49:481-491