Hippocampal volume reduction correlates with apathy in traumatic brain injury, But not schizophrenia

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 25, Issue 4, 2013, Pages 292-301

  Takayanagi, Yoichiro ^a,b   Gerner, Gwendoly ^a,b   Takayanagi, Mizuho ^a,b   Rao, Vani ^a,b   Vannorsdall, Tracy D ^a,b   Sawa, Akira ^a,b   Schretlen, David J ^a,b   Cascella, Nicola G ^a,b  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; APATHY; ARTICLE; BRAIN SIZE; BRAIN STEM; CAUDATE NUCLEUS; CONTROLLED STUDY; CORPUS CALLOSUM; CORTICAL THICKNESS (BRAIN); DIENCEPHALON; DSM-IV; FEMALE; GLASGOW COMA SCALE; GLOBUS PALLIDUS; GRAY MATTER; HIPPOCAMPUS; HUMAN; INTERRATER RELIABILITY; LEARNING; MAJOR CLINICAL STUDY; MALE; NEGATIVE SYNDROME; NEUROIMAGING; NEUROPSYCHIATRY; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PERSONALITY DISORDER; PRIORITY JOURNAL; PUTAMEN; SCHIZOPHRENIA; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; SURVIVOR; TASK PERFORMANCE; THALAMUS; TRAFFIC ACCIDENT; TRAUMATIC BRAIN INJURY; WHITE MATTER;

ADULT; APATHY; ATROPHY; BRAIN; BRAIN INJURIES; CASE-CONTROL STUDIES; FEMALE; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; NEUROIMAGING; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; YOUNG ADULT;

EID: 84901296580     PISSN: 08950172     EISSN: 15457222     Source Type: Journal    
DOI: 10.1176/appi.neuropsych.12040093     Document Type: Article

References (44)

1. Marin RS, Wilkosz PA: Disorders of diminished motivation. J Head Trauma Rehabil 2005; 20:377-388
2. Kant R, Duffy JD, Pivovarnik A: Prevalence of apathy following head injury. Brain Inj 1998; 12:87-92
3. Carpenter WT Jr, Heinrichs DW, Wagman AM: Deficit and nondeficit forms of schizophrenia: the concept. Am J Psychiatry 1988; 145:578-583
4. Landes AM, Sperry SD, Strauss ME, et al: Apathy in Alzheimer's disease. J Am Geriatr Soc 2001; 49:1700-1707
5. Schrag A: Psychiatric aspects of Parkinson's disease: an update. J Neurol 2004; 251:795-804
6. van Zomeren AH, van den Burg W: Residual complaints of patients two years after severe head injury. J Neurol Neurosurg Psychiatry 1985; 48:21-28
7. Burgess N, Maguire EA, O'Keefe J: The human hippocampus and spatial and episodic memory. Neuron 2002; 35:625-641
8. Oddy M, Coughlan T, Tyerman A, et al: Social adjustment after closed head injury: a further follow-up seven years after injury. J Neurol Neurosurg Psychiatry 1985; 48:564-568
9. Arango C, Buchanan RW, Kirkpatrick B, et al: The deficit syndrome in schizophrenia: implications for the treatment of negative symptoms. Eur Psychiatry 2004; 19:21-26
10. Rao V, Spiro JR, Schretlen DJ, et al: Apathy syndrome after traumatic brain injury compared with deficits in schizophrenia. Psychosomatics 2007; 48:217-222
11. Bigler ED, Blatter DD, Anderson CV, et al: Hippocampal volume in normal aging and traumatic brain injury. AJNR Am J Neuroradiol 1997; 18:11-23
12. Bigler ED: Quantitative magnetic resonance imaging in traumatic brain injury. J Head Trauma Rehabil 2001; 16:117-134
13. MacKenzie JD, Siddiqi F, Babb JS, et al: Brain atrophy in mild or moderate traumatic brain injury: a longitudinal quantitative analysis. AJNR Am J Neuroradiol 2002; 23:1509-1515
14. 1-weightedMRI study. J Neurol Neurosurg Psychiatry 2004; 75:1314-1322
15. Tomaiuolo F, Worsley KJ, Lerch J, et al: Changes in white matter in long-term survivors of severe non-missile traumatic brain injury: a computational analysis of magnetic resonance images. J Neurotrauma 2005; 22:76-82
16. Gale SD, Baxter L, Roundy N, et al: Traumatic brain injury and grey matter concentration: a preliminary voxel based morphometry study. J Neurol Neurosurg Psychiatry 2005; 76:984-988
17. Ariza M, Serra-Grabulosa JM, Junqué C, et al: Hippocampal head atrophy after traumatic brain injury. Neuropsychologia 2006; 44:1956-1961
18. Ding K, Marquez de la Plata C, Wang JY, et al: Cerebral atrophy after traumatic white matter injury: correlation with acute neuroimaging and outcome. J Neurotrauma 2008; 25:1433-1440
19. Sidaros A, Skimminge A, Liptrot MG, et al: Long-term global and regional brain volume changes following severe traumatic brain injury: a longitudinal study with clinical correlates. Neuroimage 2009; 44:1-8
20. Vannorsdall TD, Cascella NG, Rao V, et al: A morphometric analysis of neuroanatomic abnormalities in traumatic brain injury. J Neuropsychiatry Clin Neurosci 2010; 22:173-181
21. Warner MA, Youn TS, Davis T, et al: Regionally selective atrophy after traumatic axonal injury. Arch Neurol 2010; 67:1336-1344
22. Turetsky B, Cowell PE, Gur RC, et al: Frontal and temporal lobe brain volumes in schizophrenia: relationship to symptoms and clinical subtype. Arch Gen Psychiatry 1995; 52:1061-1070
23. Sanfilipo M, Lafargue T, Rusinek H, et al: Volumetric measure of the frontal and temporal lobe regions in schizophrenia: relationship to negative symptoms. Arch Gen Psychiatry 2000; 57:471-480
24. Sigmundsson T, Suckling J, Maier M, et al: Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white-matter tracts in schizophrenic patients with prominent negative symptoms. Am J Psychiatry 2001; 158:234-243
25. Cascella NG, Fieldstone SC, Rao VA, et al: Gray-matter abnormalities in deficit schizophrenia. Schizophr Res 2010; 120:63-70
26. Cascella NG, Testa SM, Meyer SM, et al: Neuropsychological impairment in deficit vs. non-deficit schizophrenia. J Psychiatr Res 2008; 42:930-937; available at doi: 10.1016/j.jpsychires.2007.10.002
27. Liddle PF, Morris DL: Schizophrenic syndromes and frontal lobe performance. Br J Psychiatry 1991; 158:340-345
28. Stolar N, Berenbaum H, Banich MT, et al: Neuropsychological correlates of alogia and affective flattening in schizophrenia. Biol Psychiatry 1994; 35:164-172
29. Andersson S, Bergedalen AM: Cognitive correlates of apathy in traumatic brain injury. Neuropsychiatry Neuropsychol Behav Neurol 2002; 15:184-191
30. Kirkpatrick B, Buchanan RW, McKenney PD, et al: The Schedule for the Deficit Syndrome: an instrument for research in schizophrenia. Psychiatry Res 1989; 30:119-123
31. Marin RS, Biedrzycki RC, Firinciogullari S: Reliability and validity of the Apathy Evaluation Scale. Psychiatry Res 1991; 38:143-162
32. Clarke DE, Ko JY, Kuhl EA, et al: Are the available apathy measures reliable and valid? a review of the psychometric evidence. J Psychosom Res 2011; 70:73-97
33. Blair J: Predicting premorbid IQ: a revision of the National Adult Reading Test. Clin Neuropsychol 1989; 3:129-136
34. Wing JK, Sartorius N, Ustun TB: Schedules for Clinical Assessment in Neuropsychiatry (SCAN), Version 2.1. Geneva, Switzerland, World Health Organization, 1996
35. Takayanagi Y, Takahashi T, Orikabe L, et al: Classification of first-episode schizophrenia patients and healthy subjects by automated MRI measures of regional brain volume and cortical thickness. PLoS ONE 2011; 6:e21047
36. Eichenbaum H, Yonelinas AP, Ranganath C: The medial temporal lobe and recognition memory. Annu Rev Neurosci 2007; 30:123-152
37. Szabo K, Förster A, Jäger T, et al: Hippocampal lesion patterns in acute posterior cerebral artery stroke: clinical and MRI findings. Stroke 2009; 40:2042-2045
38. Jorge RE, Starkstein SE, Robinson RG: Apathy following stroke. Can J Psychiatry 2010; 55:350-354
39. Matsushita M, Oyanagi S, Hanawa S, et al: Nasu-Hakola's disease (membranous lipodystrophy): a case report. Acta Neuropathol 1981; 54:89-93
40. Stuss D, van Reekum R, Murphy K: Differentiation of states and causes of apathy, in The Neuropsychology of Emotion. Edited by Borod J. New York, Oxford University Press, 2000
41. Alexander GE, DeLong MR, Strick PL: Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 1986; 9:357-381
42. HampshireA, ChaudhryAM, OwenAM, et al: Dissociable roles for lateral orbitofrontal cortex and lateral prefrontal cortex during preference driven reversal learning. Neuroimage 2012; 59:4102-4112
43. Leeson VC, Robbins TW, Matheson E, et al: Discrimination learning, reversal, and set-shifting in first-episode schizophrenia: stability over six years and specific associations with medication type and disorganization syndrome. Biol Psychiatry 2009; 66:586-593
44. Roth RM, Flashman LA, Saykin AJ, et al: Apathy in schizophrenia: reduced frontal lobe volume and neuropsychological deficits. Am J Psychiatry 2004; 161:157-159