Azilsartan increases levels of IL-10, down-regulates MMP-2, MMP-9, RANKL/RANK, cathepsin K and up-regulates OPG in an experimental periodontitis model

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  De Araújo, Aurigena Antunes ^a   Varela, Hugo ^a   De Brito, Gerly Anne Castro ^b   De Medeiros, Caroline Addison Carvalho Xavier ^c   De Araújo, Lorena Souza ^a   Do Nascimento, José Heriberto Oliveira ^a   De Araújo Jr , Raimundo Fernandes ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

^b FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^c DEPARTAMENTO DE FÍSICA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

AZILSARTAN; AZILSARTAN MEDOXOMIL; CATHEPSIN K; CYCLOOXYGENASE 2; CYTOKINE; GELATINASE A; GELATINASE B; GLUTATHIONE; INTERLEUKIN 10; INTERLEUKIN 1BETA; MYELOPEROXIDASE; OSTEOCLAST DIFFERENTIATION FACTOR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TUMOR NECROSIS FACTOR ALPHA; BENZIMIDAZOLE DERIVATIVE; OSTEOPROTEGERIN; OXADIAZOLE DERIVATIVE;

ALVEOLAR BONE LOSS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PERIODONTITIS; PROTEIN EXPRESSION; RAT; UPREGULATION; ANIMAL; BLOOD; WISTAR RAT;

ANIMALS; BENZIMIDAZOLES; CATHEPSIN K; INTERLEUKIN-10; INTERLEUKIN-1BETA; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; OSTEOPROTEGERIN; OXADIAZOLES; PERIODONTITIS; RATS; RATS, WISTAR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84901274544     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096750     Document Type: Article

References (32)

1. Elavarasu S, Sekar S, Murugan T (2012) Host modulation by therapeutic agents. J Pharm Bioallied Sci 4: S256-259.
2. Araujo AA, Souza TO, Moura LM, Brito GA, Aragao KS, et al. (2013) Effect of telmisartan on levels of IL-1, TNF-alpha, down-regulated COX-2, MMP-2, MMP-9 and RANKL/RANK in an experimental periodontitis model. J Clin Periodontol 40: 1104-1111.
3. Araujo AA, Lopes de Souza G, Souza TO, de Castro Brito GA, Saboia Aragao K, et al. (2013) Olmesartan decreases IL-1beta and TNF-alpha levels; downregulates MMP-2, MMP-9, COX-2, and RANKL; and upregulates OPG in experimental periodontitis. Naunyn Schmiedebergs Arch Pharmacol 386: 875-884.
4. de Araujo Junior RF, Souza TO, de Medeiros CA, de Souza LB, Freitas Mde L, et al. (2013) Carvedilol decrease IL-1beta and TNF-alpha, inhibits MMP-2, MMP-9, COX-2, and RANKL expression, and up-regulates OPG in a rat model of periodontitis. Plos One 8: e66391.
5. de Araujo Junior RF, Souza TO, de Moura LM, Torres KP, de Souza LB, et al. (2013) Atorvastatin decreases bone loss, inflammation and oxidative stress in experimental periodontitis. Plos One 8: e75322.
6. Nakano A, Hattori Y, Aoki C, Jojima T, Kasai K (2009) Telmisartan inhibits cytokine-induced nuclear factor-kappaB activation independently of the peroxisome proliferator-activated receptor-gamma. Hypertens Res 32: 765-769.
7. Zaiken K, Cheng JW (2011) Azilsartan medoxomil: a new Angiotensin receptor blocker. Clinical Therapeutics 33: 1577-1589.
8. Carvalho RS, de Souza CM, Neves JC, Holanda-Pinto SA, Pinto LM, et al. (2010) Effect of venlafaxine on bone loss associated with ligature-induced periodontitis in Wistar rats. J Negat Results Biomed 9: 3.
9. Wienen W, Hauel N, Van Meel JC, Narr B, Ries U, et al. (1993) Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277. Br J Pharmacol 110: 245-252. (Pubitemid 23257787)
10. Wienen W, Richard S, Champeroux P, Audeval-Gerard C (2001) Comparative antihypertensive and renoprotective effects of telmisartan and lisinopril after long-term treatment in hypertensive diabetic rats. Journal of the Renin-Angiotensin-Aldosterone System 2: 31-36. (Pubitemid 33687416)
11. Carvalho Rde S, de Souza CM, Neves JC, Holanda-Pinto SA, Pinto LM, et al. (2013) Vitamin E does not prevent bone loss and induced anxiety in rats with ligature-induced periodontitis. Arch Oral Biol 58: 50-58.
12. Leitao RF, Ribeiro RA, Chaves HV, Rocha FA, Lima V, et al. (2005) Nitric oxide synthase inhibition prevents alveolar bone resorption in experimental periodontitis in rats. J Periodontol 76: 956-963. (Pubitemid 40903838)
13. Souza MH, Troncon LE, Cunha FQ, Oliveira RB (2003) Decreased gastric tone and delayed gastric emptying precede neutrophil infiltration and mucosal lesion formation in indomethacin-induced gastric damage in rats. Brazilian Journal of Medical and Biological Research 36: 1383-1390. (Pubitemid 37322268)
14. Safieh-Garabedian B, Poole S, Allchorne A, Winter J, Woolf CJ (1995) Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. Br J Pharmacol 115: 1265-1275.
15. Kendall C, Ionescu-Matiu I, Dreesman GR (1983) Utilization of the biotin/avidin system to amplify the sensitivity of the enzyme-linked immunosorbent assay (ELISA). J Immunol Methods 56: 329-339. (Pubitemid 13186885)
16. Sanz M, van Winkelhoff AJ (2011) Periodontal infections: understanding the complexity-consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol 38 Suppl 11: 3-6.
17. Graves DT, Li J, Cochran DL (2011) Inflammation and uncoupling as mechanisms of periodontal bone loss. Journal of Dental Research 90: 143-153.
18. Graves D (2008) Cytokines that promote periodontal tissue destruction. J Periodontol 79: 1585-1591.
19. Yamaguchi M, Kasai K (2005) Inflammation in periodontal tissues in response to mechanical forces. Arch Immunol Ther Exp (Warsz) 53: 388-398. (Pubitemid 43116639)
20. Gaddis DE, Maynard CL, Weaver CT, Michalek SM, Katz J (2013) Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-gamma T cell response to Porphyromonas gingivalis. J Leukoc Biol 93: 21-31.
21. Takeda K, Akira S (2004) TLR signaling pathways. Semin Immunol 16: 3-9. (Pubitemid 38147427)
22. Curtale G, Mirolo M, Renzi TA, Rossato M, Bazzoni F, et al. (2013) Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b. Proc Natl Acad Sci U S A 110: 11499-11504.
23. Liu DW, Yao SM, Wise GE (2006) Effect of interleukin-10 on gene expression of osteoclastogenic regulatory molecules in the rat dental follicle. Eur J Oral Sci 114: 42-49.
24. Lovibond AC, Haque SJ, Chambers TJ, Fox SW (2003) TGF-beta-induced SOCS3 expression augments TNF-alpha-induced osteoclast formation. Biochem Biophys Res Commun 309: 762-767. (Pubitemid 37122593)
25. Kusano K, Miyaura C, Inada M, Tamura T, Ito A, et al. (1998) Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption. Endocrinology 139: 1338-1345. (Pubitemid 28510155)
26. Sasaki H, Okamatsu Y, Kawai T, Kent R, Taubman M, et al. (2004) The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss. J Periodontal Res 39: 432-441. (Pubitemid 39523888)
27. Evans KE, Fox SW (2007) Interleukin-10 inhibits osteoclastogenesis by reducing NFATcI expression and preventing its translocation to the nucleus. BMC Cell Biol 8.
28. Mohamed SGK, Sugiyama E, Shinoda K, Taki H, Hounoki H, et al. (2007) Interleukin-10 inhibits RANKL-mediated expression of NFATc I in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells. Bone 41: 592-602. (Pubitemid 47385426)
29. Garlet GP, Cardoso CR, Silva TA, Ferreira BR, Avila-Campos MJ, et al. (2006) Cytokine pattern determines the progression of experimental periodontal disease induced by Actinobacillus actinomycetemcomitans through the modulation of MMPs, RANKL, and their physiological inhibitors. Oral Microbiol Immunol 21: 12-20.
30. Bostanci N, Saygan B, Emingil G, Atilla G, Belibasakis GN (2011) Effect of periodontal treatment on receptor activator of NF-kappaB ligand and osteoprotegerin levels and relative ratio in gingival crevicular fluid. J Clin Periodontol 38: 428-433.
31. Salvi GE, Lang NP (2005) Host response modulation in the management of periodontal diseases. J Clin Periodontol 32 Suppl 6: 108-129. (Pubitemid 41391060)
32. Soung do Y, Gentile MA, Duong le T, Drissi H (2013) Effects of pharmacological inhibition of cathepsin K on fracture repair in mice. Bone 55: 248-255.