Association of the luteinizing hormone/choriogonadotropin receptor gene polymorphism with polycystic ovary syndrome

Gynecological Endocrinology

Volumn 30, Issue 6, 2014, Pages 428-430

  Bassiouny, Yasmin Ahmed ^a   Rabie, Walaa Ahmed ^a   Hassan, Ayman Ahmed ^a   Darwish, Rania Kamal ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

G935A polymorphism; Genetic factors; Luteinizing hormone choriogonadotropin receptor gene; Polycystic ovary syndrome; Polymerase chain reaction restriction fragment length polymorphism technique; Single nucleotide polymorphism

Indexed keywords

DNA; ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR; PROGESTERONE; PROLACTIN; TESTOSTERONE; THYROTROPIN;

ADULT; AMENORRHEA; ARTICLE; BODY MASS; CASE CONTROL STUDY; CONTROLLED STUDY; DNA DETERMINATION; DNA EXTRACTION; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; HIRSUTISM; HUMAN; HYPERANDROGENISM; LHCGR GENE; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; OLIGOMENORRHEA; OVARY DISEASE; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PROLACTIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM; TESTOSTERONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; ALLELE; AMINO ACID SUBSTITUTION; BLOOD; COMPLICATION; EGYPT; GENETIC PREDISPOSITION; GENETICS; HETEROZYGOTE; HOMOZYGOTE; METABOLISM; OBESITY; OUTPATIENT DEPARTMENT; UNIVERSITY HOSPITAL; YOUNG ADULT;

ADULT; ALLELES; AMINO ACID SUBSTITUTION; BODY MASS INDEX; CASE-CONTROL STUDIES; EGYPT; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HOMOZYGOTE; HOSPITALS, UNIVERSITY; HUMANS; OBESITY; OUTPATIENT CLINICS, HOSPITAL; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, LH; YOUNG ADULT;

EID: 84901260995     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2014.895982     Document Type: Article

References (14)

1. Ehrmann DA. Polycystic ovary syndrome. N Engl J Med 2005;352: 1223-36
2. Sam S, Dunaif A. Polycystic ovary syndrome: Syndrome XX? Trends Endocrinol Metab 2003;14:365-70
3. Deligeoroglou E, Kouskouti C, Christopoulos P. The role of genes in the polycystic ovary syndrome: Predisposition and mechanisms. Gynecol Endocrinol 2009;25:603-9
4. Crosignani PG, Nicolosi AE. Polycystic ovarian disease: Heritability and heterogeneity. Hum Reprod Update 2001;7:3-7. (Pubitemid 32111960
5. Mahban A, Shemirani AI, Mahmoudi T, et al. Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome. J Assist Reprod Genet 2011;28:225-32
6. Dos Santos E, Dieudonné MN, Leneveu MC, et al. In vitro effects of chorionicgonadotropin hormone on human adipose development. J Endocrinol 2001;194:313-25
7. Nelson-Degrave VL, Wickenheisser JK, Hendricks KL, et al. Alterations in mitogen-Activated protein kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome. Mol Endocrinol 2005;19:379-90. (Pubitemid 40223462
8. Piersma D, Berns EM, Verhoef-Post M, et al. A common polymorphism renders the luteinizing hormone receptor protein more active by improving signal peptide function and predicts adverse outcome in breast cancer patients. J Clin Endocrinol Metab 2006;91:1470-6
9. Capalbo A, Sagnella F, Apa R, et al. The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2-7-fold increased risk of polycystic ovary syndrome in a Sardinian population. Clin Endocrinol (Oxf) 2012;77: 113-9
10. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-Term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25
11. Trowsdale J. Genomic structure and function in MHC. Trends Genet 1993;9:117-21
12. Ehrmann DA. Polycystic ovary syndrome. N Engl J Med 2005;352: 1223-6
13. Kulshreshtha B, Singh S, Arora A. Family background of diabetes mellitus, obesity and hypertension affects the phenotype and first symptom of patients with PCOS. Gynecol Endocrinol 2013;29: 1040-4
14. Valkenburg O, Uitterlinden AG, Piersma D, et al. Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome. Hum Reprod 2009;24:2014-22